2JRF

Solution NMR structure of Tubulin polymerization-promoting protein family member 3 from Homo sapiens. Northeast Structural Genomics target HR387.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	p25-alpha	e2jrfA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: p25-alpha	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05517	p25-alpha (p25-alpha)	p25-alpha	This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase [1]. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tubulin polymerization-promoting protein family member 3	cytoskeletal protein binding protein binding binding tubulin binding	cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization protein polymerization protein-containing complex organization microtubule polymerization cellular component biogenesis microtubule polymerization or depolymerization cellular component assembly cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cellular process microtubule-based process cellular component organization or biogenesis cytoskeleton organization protein polymerization protein-containing complex organization microtubule polymerization cellular component biogenesis microtubule polymerization or depolymerization cellular component assembly protein-containing complex assembly supramolecular fiber organization developmental process multi-multicellular organism process multicellular organismal process placenta development reproductive process maternal process involved in female pregnancy multicellular organismal reproductive process animal organ development developmental process involved in reproduction tissue development maternal placenta development anatomical structure development female pregnancy multi-organism reproductive process decidualization regulation of biological process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of cellular component biogenesis biological regulation positive regulation of biological process regulation of cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly regulation of protein polymerization positive regulation of protein polymerization positive regulation of cellular process multicellular organism development embryo implantation	intracellular anatomical structure cytoplasm cellular anatomical entity polymeric cytoskeletal fiber intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR008907	Tubulin polymerization-promoting protein	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.