2JKR

AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2jkrb_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Clathrin adaptor core protein	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth E]	d2jkre_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Clathrin adaptor core protein	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth I]	d2jkri_	Alpha and beta proteins (a+b)	Profilin-like	SNARE-like	Clathrin coat assembly domain	Sigma2 adaptin (clathrin coat assembly protein AP17)	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
I [auth S]	d2jkrs_	Alpha and beta proteins (a+b)	Profilin-like	SNARE-like	Clathrin coat assembly domain	Sigma2 adaptin (clathrin coat assembly protein AP17)	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	ARM repeat-like	8039144	3000116	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	ARM repeat-like	8039144	3000116	SCOP2B (2022-06-29)
D [auth I]	SCOP2B Superfamily	SNARE-like	8039154	3001113	SCOP2B (2022-06-29)
I [auth S]	SCOP2B Superfamily	SNARE-like	8039154	3001113	SCOP2B (2022-06-29)
F [auth M]	SCOP2B Superfamily	SNARE-like	8039151	3001113	SCOP2B (2022-06-29)
F [auth M]	SCOP2B Superfamily	mu adaptin domain-like	8036010	3000810	SCOP2B (2022-06-29)
J [auth U]	SCOP2B Superfamily	mu adaptin domain-like	8036010	3000810	SCOP2B (2022-06-29)
J [auth U]	SCOP2B Superfamily	SNARE-like	8039151	3001113	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adaptin_N	e2jkrA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Adaptin_N	ECOD (1.6)
E [auth L]	Adaptin_N	e2jkrL1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Adaptin_N	ECOD (1.6)
B	Adaptin_N	e2jkrB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Adaptin_N	ECOD (1.6)
C [auth E]	Adaptin_N	e2jkrE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Adaptin_N	ECOD (1.6)
D [auth I]	Clat_adaptor_s	e2jkrI1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Clat_adaptor_s	ECOD (1.6)
I [auth S]	Clat_adaptor_s	e2jkrS1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Clat_adaptor_s	ECOD (1.6)
F [auth M]	Adap_comp_sub_2nd	e2jkrM3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Adap_comp_sub_2nd	ECOD (1.6)
F [auth M]	Adap_comp_sub_1st	e2jkrM2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Adap_comp_sub_1st	ECOD (1.6)
F [auth M]	Clat_adaptor_s	e2jkrM1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Clat_adaptor_s	ECOD (1.6)
J [auth U]	Adap_comp_sub_2nd	e2jkrU3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Adap_comp_sub_2nd	ECOD (1.6)
J [auth U]	Adap_comp_sub_1st	e2jkrU2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Adap_comp_sub_1st	ECOD (1.6)
J [auth U]	Clat_adaptor_s	e2jkrU1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Clat_adaptor_s	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
E [auth L]	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
C [auth E]	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
D [auth I]	3.30.450.60	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
I [auth S]	3.30.450.60	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
F [auth M]	3.30.450.60	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
F [auth M]	2.60.40.1170	Mainly Beta	Sandwich	Immunoglobulin-like	Mu homology domain, subdomain B	CATH (4.3.0)
J [auth U]	3.30.450.60	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
J [auth U]	2.60.40.1170	Mainly Beta	Sandwich	Immunoglobulin-like	Mu homology domain, subdomain B	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth L]	PF01602	Adaptin N terminal region (Adaptin_N)	Adaptin N terminal region	-	Repeat
B, C [auth E]	PF01602	Adaptin N terminal region (Adaptin_N)	Adaptin N terminal region	-	Repeat
D [auth I], I [auth S]	PF01217	Clathrin adaptor complex small chain (Clat_adaptor_s)	Clathrin adaptor complex small chain	-	Domain
F [auth M], J [auth U]	PF01217	Clathrin adaptor complex small chain (Clat_adaptor_s)	Clathrin adaptor complex small chain	-	Domain
F [auth M], J [auth U]	PF00928	Adaptor complexes medium subunit family (Adap_comp_sub)	Adaptor complexes medium subunit family	-	Family
G [auth P], H [auth Q]	PF12104	T cell CD4 receptor C terminal region (Tcell_CD4_C)	T cell CD4 receptor C terminal region	This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalisation. This domain is involved in binding to t ...	This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalisation. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth L]	AP-2 COMPLEX SUBUNIT ALPHA-2	binding phospholipid binding lipid binding phosphatidylinositol binding protein binding protein domain specific binding kinase binding enzyme binding protein serine/threonine kinase binding protein kinase binding protein-containing complex binding cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity binding phospholipid binding lipid binding phosphatidylinositol binding protein binding protein domain specific binding kinase binding enzyme binding protein serine/threonine kinase binding protein kinase binding protein-containing complex binding cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity disordered domain specific binding	developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process hemopoiesis biological regulation cell development regulation of cell differentiation regulation of hematopoietic stem cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation anatomical structure development hematopoietic stem cell differentiation developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process hemopoiesis biological regulation cell development regulation of cell differentiation regulation of hematopoietic stem cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation anatomical structure development hematopoietic stem cell differentiation cellular process regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation localization import into cell transport clathrin-dependent endocytosis receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport cellular localization receptor internalization postsynaptic neurotransmitter receptor internalization vesicle-mediated transport in synapse protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis establishment of localization in cell regulation of biological quality protein localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport	membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle protein-containing complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle protein-containing complex vesicle coat membrane protein complex membrane coat cell periphery bounding membrane of organelle AP-type membrane coat adaptor complex AP-2 adaptor complex vesicle membrane clathrin-coated pit clathrin-coated vesicle endocytic vesicle membrane coated vesicle clathrin vesicle coat endocytic vesicle clathrin-coated vesicle membrane clathrin coat of coated pit clathrin coat of endocytic vesicle clathrin-coated endocytic vesicle membrane plasma membrane protein complex membrane plasma membrane coated membrane clathrin-coated endocytic vesicle clathrin coat cytoplasmic vesicle membrane coated vesicle membrane organelle membrane clathrin adaptor complex cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane postsynapse synapse cell junction transport vesicle presynapse synaptic vesicle exocytic vesicle
B, C [auth E]	AP-2 COMPLEX SUBUNIT BETA-1	clathrin binding protein binding binding signal sequence binding peptide binding	synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis developmental process heart development multicellular organismal process animal organ development ventricular septum development circulatory system development multicellular organism development cardiac septum development cardiac chamber development anatomical structure development cardiac ventricle development system development artery development aorta development vasculature development blood vessel development clathrin-dependent endocytosis receptor-mediated endocytosis receptor internalization postsynaptic neurotransmitter receptor internalization biological regulation protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis regulation of biological quality protein localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport coronary vasculature development kidney development renal system development	membrane cellular anatomical entity protein-containing complex intracellular anatomical structure membrane protein complex coated membrane clathrin coat membrane coat AP-type membrane coat adaptor complex cytoplasm clathrin adaptor complex endosome membrane membrane-bounded organelle endolysosome membrane membrane cellular anatomical entity protein-containing complex intracellular anatomical structure membrane protein complex coated membrane clathrin coat membrane coat AP-type membrane coat adaptor complex cytoplasm clathrin adaptor complex endosome membrane membrane-bounded organelle endolysosome membrane intracellular vesicle lytic vacuole endomembrane system intracellular organelle bounding membrane of organelle endolysosome vesicle membrane cytoplasmic vesicle vesicle lysosome vacuolar membrane endosome vacuole intracellular membrane-bounded organelle lytic vacuole membrane cytoplasmic vesicle membrane organelle lysosomal membrane organelle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle coated vesicle membrane cytosol cell periphery plasma membrane presynapse synapse cell junction vesicle coat AP-2 adaptor complex clathrin-coated pit clathrin vesicle coat clathrin coat of coated pit clathrin coat of endocytic vesicle plasma membrane protein complex glutamatergic synapse cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane postsynapse
D [auth I], I [auth S]	AP-2 COMPLEX SUBUNIT SIGMA-1	cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport synaptic vesicle endocytosis import into cell synaptic vesicle cycle vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling endocytosis clathrin-dependent endocytosis receptor-mediated endocytosis receptor internalization postsynaptic neurotransmitter receptor internalization biological regulation protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis regulation of biological quality	synapse cell junction cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle protein-containing complex vesicle coat intracellular vesicle membrane protein complex endomembrane system membrane coat synapse cell junction cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle protein-containing complex vesicle coat intracellular vesicle membrane protein complex endomembrane system membrane coat cell periphery bounding membrane of organelle AP-type membrane coat adaptor complex AP-2 adaptor complex cytoplasmic vesicle vesicle membrane clathrin-coated pit clathrin-coated vesicle endocytic vesicle membrane coated vesicle clathrin vesicle coat vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin coat of coated pit clathrin coat of endocytic vesicle clathrin-coated endocytic vesicle membrane plasma membrane protein complex membrane plasma membrane coated membrane clathrin-coated endocytic vesicle clathrin coat cytoplasmic vesicle membrane coated vesicle membrane cytoplasm organelle membrane clathrin adaptor complex cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane postsynapse glutamatergic synapse extrinsic component of plasma membrane presynaptic endocytic zone presynaptic membrane extrinsic component of presynaptic endocytic zone membrane synaptic membrane extrinsic component of synaptic membrane presynapse presynaptic endocytic zone membrane extrinsic component of presynaptic membrane plasma membrane region extrinsic component of membrane
F [auth M], J [auth U]	AP-2 COMPLEX SUBUNIT MU-1	signal sequence binding binding peptide binding protein binding transmembrane transporter binding lipid binding cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding disordered domain specific binding signal sequence binding binding peptide binding protein binding transmembrane transporter binding lipid binding cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding disordered domain specific binding protein domain specific binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell endocytosis protein localization regulation of localization regulation of cellular process regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane cellular macromolecule localization negative regulation of cellular process regulation of protein localization to membrane negative regulation of protein localization regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization macromolecule localization negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane receptor internalization receptor-mediated endocytosis regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport clathrin-dependent endocytosis postsynaptic neurotransmitter receptor internalization protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis regulation of biological quality regulation of cellular component size regulation of vesicle size regulation of anatomical structure size membrane organization vesicle budding from membrane vesicle organization organelle organization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport intracellular protein transport positive regulation of synaptic vesicle recycling regulation of synaptic vesicle recycling regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis	clathrin-coated pit membrane cellular anatomical entity endomembrane system axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction clathrin-coated pit membrane cellular anatomical entity endomembrane system axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton cell junction neuron projection terminus cell periphery plasma membrane membrane-bounded organelle protein-containing complex intracellular anatomical structure vesicle coat intracellular vesicle membrane protein complex intracellular organelle membrane coat bounding membrane of organelle AP-type membrane coat adaptor complex AP-2 adaptor complex cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle clathrin vesicle coat vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin coat of coated pit clathrin coat of endocytic vesicle clathrin-coated endocytic vesicle membrane plasma membrane protein complex intracellular membrane-bounded organelle coated membrane clathrin-coated endocytic vesicle clathrin coat cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane clathrin adaptor complex glutamatergic synapse extrinsic component of plasma membrane presynaptic endocytic zone presynaptic membrane extrinsic component of presynaptic endocytic zone membrane synaptic membrane extrinsic component of synaptic membrane presynaptic endocytic zone membrane extrinsic component of presynaptic membrane plasma membrane region extrinsic component of membrane postsynapse
G [auth P], H [auth Q]	CD4 PEPTIDE	molecular transducer activity coreceptor activity signaling receptor activity protein-containing complex binding binding MHC protein complex binding MHC class II protein complex binding interleukin-16 binding protein binding cytokine binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding molecular transducer activity coreceptor activity signaling receptor activity protein-containing complex binding binding MHC protein complex binding MHC class II protein complex binding interleukin-16 binding protein binding cytokine binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding identical protein binding transmembrane signaling receptor activity virus receptor activity exogenous protein binding signaling receptor binding MHC class II protein binding MHC protein binding interleukin-16 receptor activity cytokine receptor activity immune receptor activity structural molecule activity extracellular matrix structural constituent protein homodimerization activity protein dimerization activity lipid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication cellular process positive regulation of signaling maintenance of protein location protein localization localization cellular localization maintenance of protein location in cell cellular macromolecule localization macromolecule localization maintenance of location maintenance of location in cell immune response immune system process adaptive immune response regulation of calcium ion transport regulation of localization transport regulation of transport regulation of monoatomic ion transport establishment of localization metal ion transport calcium ion transport monoatomic ion transport regulation of metal ion transport monoatomic cation transport positive regulation of phosphorylation regulation of catalytic activity positive regulation of cellular metabolic process regulation of transferase activity positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of molecular function regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process positive regulation of catalytic activity regulation of cellular metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of phosphorylation regulation of phosphorus metabolic process metabolic process regulation of metabolic process developmental process multicellular organismal process cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation cell differentiation anatomical structure development T cell differentiation leukocyte differentiation interleukin-15-mediated signaling pathway response to organic substance cell surface receptor signaling pathway response to cytokine cellular response to interleukin-15 cytokine-mediated signaling pathway cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance response to interleukin-15 regulation of leukocyte activation regulation of cell activation regulation of T cell activation regulation of multicellular organismal process regulation of immune system process regulation of lymphocyte activation myeloid leukocyte differentiation regulation of leukocyte differentiation positive regulation of monocyte differentiation regulation of developmental process regulation of cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell differentiation positive regulation of hemopoiesis monocyte differentiation positive regulation of immune system process regulation of multicellular organismal development regulation of monocyte differentiation regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of leukocyte differentiation cell adhesion biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus regulation of primary metabolic process positive regulation of macromolecule metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification macromolecule metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process organic substance metabolic process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process positive regulation of viral life cycle positive regulation of viral process viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process symbiont entry into host cell viral process symbiont entry into host positive regulation of viral entry into host cell positive regulation by symbiont of entry into host regulation of biological process involved in symbiotic interaction adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains helper T cell enhancement of adaptive immune response positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response regulation of immune response positive regulation of adaptive immune response positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade T cell selection response to granulocyte macrophage colony-stimulating factor cellular response to granulocyte macrophage colony-stimulating factor stimulus macrophage differentiation cellular biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of biosynthetic process regulation of interleukin-2 production interleukin-2 production gene expression macromolecule biosynthetic process positive regulation of interleukin-2 production regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cytokine production positive regulation of cellular biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process enzyme-linked receptor protein signaling pathway positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell-cell adhesion positive regulation of leukocyte activation regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of leukocyte cell-cell adhesion cell surface receptor protein tyrosine kinase signaling pathway peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation peptidyl-amino acid modification regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane membrane-enclosed lumen endomembrane system intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex T cell receptor complex receptor complex membrane microdomain membrane raft organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane early endosome endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth L]	IPR016024	Armadillo-type fold	Homologous Superfamily
A, E [auth L]	IPR003164	Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain	Domain
A, E [auth L]	IPR011989	Armadillo-like helical	Homologous Superfamily
A, E [auth L]	IPR012295	TBP domain superfamily	Homologous Superfamily
A, E [auth L]	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal	Domain
A, E [auth L]	IPR013041	Clathrin adaptor, appendage, Ig-like subdomain superfamily	Homologous Superfamily
A, E [auth L]	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain	Domain
A, E [auth L]	IPR017104	Adaptor protein complex AP-2, alpha subunit	Family
A, E [auth L]	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain	Homologous Superfamily
B, C [auth E]	IPR016024	Armadillo-type fold	Homologous Superfamily
B, C [auth E]	IPR013037	Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain	Homologous Superfamily
B, C [auth E]	IPR000225	Armadillo	Repeat
B, C [auth E]	IPR026739	AP complex subunit beta	Family
B, C [auth E]	IPR011989	Armadillo-like helical	Homologous Superfamily
B, C [auth E]	IPR012295	TBP domain superfamily	Homologous Superfamily
B, C [auth E]	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal	Domain
B, C [auth E]	IPR015151	Beta-adaptin appendage, C-terminal subdomain	Domain
B, C [auth E]	IPR013041	Clathrin adaptor, appendage, Ig-like subdomain superfamily	Homologous Superfamily
B, C [auth E]	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain	Domain
B, C [auth E]	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain	Homologous Superfamily
B, C [auth E]	IPR016342	AP-1/2/4 complex subunit beta	Family
D [auth I], I [auth S]	IPR016635	Adaptor protein complex, sigma subunit	Family
D [auth I], I [auth S]	IPR011012	Longin-like domain superfamily	Homologous Superfamily
D [auth I], I [auth S]	IPR000804	Clathrin adaptor complex, small chain	Conserved Site
D [auth I], I [auth S]	IPR022775	AP complex, mu/sigma subunit	Domain
D [auth I], I [auth S]	IPR027156	AP-2 complex subunit sigma	Family
F [auth M], J [auth U]	IPR043512	Mu2, C-terminal domain	Domain
F [auth M], J [auth U]	IPR036168	AP-2 complex subunit mu, C-terminal superfamily	Homologous Superfamily
F [auth M], J [auth U]	IPR028565	Mu homology domain	Domain
F [auth M], J [auth U]	IPR018240	Clathrin adaptor, mu subunit, conserved site	Conserved Site
F [auth M], J [auth U]	IPR001392	Clathrin adaptor, mu subunit	Family
F [auth M], J [auth U]	IPR011012	Longin-like domain superfamily	Homologous Superfamily
F [auth M], J [auth U]	IPR043532	AP-2 complex subunit mu, N-terminal	Domain
F [auth M], J [auth U]	IPR022775	AP complex, mu/sigma subunit	Domain
G [auth P], H [auth Q]	IPR021963	T cell CD4 receptor C-terminal region	Domain
G [auth P], H [auth Q]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
G [auth P], H [auth Q]	IPR013106	Immunoglobulin V-set domain	Domain
G [auth P], H [auth Q]	IPR000973	T-cell surface antigen CD4	Family
G [auth P], H [auth Q]	IPR008424	Immunoglobulin C2-set	Domain
G [auth P], H [auth Q]	IPR015274	CD4, extracellular	Domain
G [auth P], H [auth Q]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
G [auth P], H [auth Q]	IPR013151	Immunoglobulin	Domain
G [auth P], H [auth Q]	IPR007110	Immunoglobulin-like domain	Domain
G [auth P], H [auth Q]	IPR003599	Immunoglobulin subtype	Domain
G [auth P], H [auth Q]	IPR003598	Immunoglobulin subtype 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, C [auth E]	Pharos: P63010	breast cancer esophageal adenocarcinoma oligodendroglioma chronic obstructive pulmonary disease head and neck cancer ovarian cancer Depressive Symptoms interstitial lung disease
G [auth P], H [auth Q]	Pharos: P01730	Duchenne muscular dystrophy diabetes mellitus AIDS-Related Opportunistic Infections coronary artery disease lymphopenia cryptococcosis malignant glioma neutropenia Duchenne and Becker muscular dystrophy ovarian disease glioblastoma pneumonia adult acute respiratory distress syndrome hepatitis B virus infection rheumatoid arthritis Duchenne muscular dystrophy diabetes mellitus AIDS-Related Opportunistic Infections coronary artery disease lymphopenia cryptococcosis malignant glioma neutropenia Duchenne and Becker muscular dystrophy ovarian disease glioblastoma pneumonia adult acute respiratory distress syndrome hepatitis B virus infection rheumatoid arthritis HIV infectious disease severe combined immunodeficiency arthritic joint disease IgA glomerulonephritis syphilis autoimmune disease breast carcinoma influenza toxoplasmosis candidiasis kidney disease uveitis colorectal cancer lung carcinoma vertebral column disease COVID-19 lymphoproliferative syndrome cutaneous lupus erythematosus measles diarrheal disease obesity disorder peripheral neuropathy heart disease prostate disease agammaglobulinemia hepatitis C virus infection rhinitis allergic disease hypereosinophilic syndrome skin disease asthma Becker muscular dystrophy inborn carbohydrate metabolic disorder tetanus breast disease interstitial lung disease tuberculosis colitis leishmaniasis vaccinia congenital T-cell immunodeficiency lymphatic system disease Crohn disease malaria demyelinating disease Okt4 epitope deficiency encephalitis pneumocystosis helminthiasis retinitis AIDS herpes zoster sarcoidosis anemia hypertensive disorder subependymal giant cell astrocytoma atherosclerosis bone marrow disease infectious meningitis thrombocytopenia cancer invasive ductal breast carcinoma uterine disease colonic disease liver disease vasculitis