2JE0

Crystal Structure of pp32

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	L domain-like	8101539	3001010	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	L domain-like	8101539	3001010	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	L domain-like	8101539	3001010	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	L domain-like	8101539	3001010	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	L domain-like	8101539	3001010	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	L domain-like	8101539	3001010	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12799	e2je0A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF12799	ECOD (1.6)
B	PF12799	e2je0B1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF12799	ECOD (1.6)
C	PF12799	e2je0C1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF12799	ECOD (1.6)
D	PF12799	e2je0D1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF12799	ECOD (1.6)
E	PF12799	e2je0E1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF12799	ECOD (1.6)
F	PF12799	e2je0F1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF12799	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
B	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
C	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
D	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
E	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
F	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF14580	Leucine-rich repeat (LRR_9)	Leucine-rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A	protein binding binding histone binding RNA binding organic cyclic compound binding nucleic acid binding	localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation apoptotic process localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus response to stimulus signaling signal transduction intracellular signal transduction cell communication	intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001611	Leucine-rich repeat	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR003603	U2A'/phosphoprotein 32 family A, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR045081	Acidic leucine-rich nuclear phosphoprotein 32	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P39687	colorectal cancer Adenocarcinoma of Lung large cell medulloblastoma malignant ependymoma osteosarcoma psoriasis breast cancer dermatomyositis lung adenocarcinoma medulloblastoma ovarian cancer subependymal giant cell astrocytoma carcinoma of esophagus colorectal carcinoma lymphoplasmacytic lymphoma colorectal cancer Adenocarcinoma of Lung large cell medulloblastoma malignant ependymoma osteosarcoma psoriasis breast cancer dermatomyositis lung adenocarcinoma medulloblastoma ovarian cancer subependymal giant cell astrocytoma carcinoma of esophagus colorectal carcinoma lymphoplasmacytic lymphoma oligodendroglioma plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.