2J59

Crystal structure of the ARF1:ARHGAP21-ArfBD complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2j59b2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	ADP-ribosylation factor	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2j59b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d2j59a2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	ADP-ribosylation factor	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d2j59a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d2j59c2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	ADP-ribosylation factor	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d2j59c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d2j59d2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	ADP-ribosylation factor	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d2j59d3	Artifacts	Tags	Tags	Tags	N-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d2j59e2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	ADP-ribosylation factor	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d2j59e3	Artifacts	Tags	Tags	Tags	N-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d2j59f2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	ADP-ribosylation factor	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d2j59f3	Artifacts	Tags	Tags	Tags	N-terminal Tags	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H [auth N]	d2j59n_	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Rho GTPase-activating protein 21	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I [auth O]	d2j59o_	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Rho GTPase-activating protein 21	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J [auth P]	d2j59p_	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Rho GTPase-activating protein 21	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K [auth Q]	d2j59q_	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Rho GTPase-activating protein 21	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L [auth R]	d2j59r_	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Rho GTPase-activating protein 21	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth M]	d2j59m1	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Rho GTPase-activating protein 21	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Ras-like P-loop GTPases	8089852	3002022	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8089852	3002022	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ras-like P-loop GTPases	8089852	3002022	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ras-like P-loop GTPases	8089852	3002022	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ras-like P-loop GTPases	8089852	3002022	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ras-like P-loop GTPases	8089852	3002022	SCOP2B (2022-06-29)
H [auth N]	SCOP2 Family	Pleckstrin-homology domain (PH domain)	8020884	4002395	SCOP2 (2022-06-29)
H [auth N]	SCOP2 Superfamily	PH domain-like	8033264	3000134	SCOP2 (2022-06-29)
I [auth O]	SCOP2B Superfamily	PH domain-like	8033264	3000134	SCOP2B (2022-06-29)
J [auth P]	SCOP2B Superfamily	PH domain-like	8033264	3000134	SCOP2B (2022-06-29)
K [auth Q]	SCOP2B Superfamily	PH domain-like	8033264	3000134	SCOP2B (2022-06-29)
L [auth R]	SCOP2B Superfamily	PH domain-like	8033264	3000134	SCOP2B (2022-06-29)
G [auth M]	SCOP2B Superfamily	PH domain-like	8033264	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00025	e2j59B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
A	PF00025	e2j59A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
C	PF00025	e2j59C1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
D	PF00025	e2j59D1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
E	PF00025	e2j59E1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
F	PF00025	e2j59F1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00025	ECOD (1.6)
H [auth N]	PF00169	e2j59N1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
I [auth O]	PF00169	e2j59O1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
J [auth P]	PF00169	e2j59P1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
K [auth Q]	PF00169	e2j59Q1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
L [auth R]	PF00169	e2j59R1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)
G [auth M]	PF00169	e2j59M1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00169	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
E	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
H [auth N]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
I [auth O]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
J [auth P]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
K [auth Q]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
L [auth R]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
G [auth M]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
G [auth M]	1.20.5.220	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00025	ADP-ribosylation factor family (Arf)	ADP-ribosylation factor family	Pfam combines a number of different Prosite families together	Domain
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	ADP-RIBOSYLATION FACTOR 1	protein binding binding protein domain specific binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding protein binding binding protein domain specific binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding magnesium ion binding metal ion binding GDP binding enzyme regulator activity enzyme activator activity molecular function activator activity phospholipase D activator activity phospholipase activator activity molecular function regulator activity lipase activator activity pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	regulation of localization cellular localization regulation of cellular process transport positive regulation of biological process positive regulation of ER to Golgi vesicle-mediated transport vesicle-mediated transport localization establishment of localization in cell positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of biological process regulation of ER to Golgi vesicle-mediated transport regulation of localization cellular localization regulation of cellular process transport positive regulation of biological process positive regulation of ER to Golgi vesicle-mediated transport vesicle-mediated transport localization establishment of localization in cell positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of biological process regulation of ER to Golgi vesicle-mediated transport regulation of transport biological regulation intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport regulation of vesicle-mediated transport establishment of localization positive regulation of transport regulation of cellular localization cellular process Golgi vesicle transport late endosome to lysosome transport lysosomal transport positive regulation of late endosome to lysosome transport positive regulation of vacuolar transport regulation of vacuolar transport vacuolar transport regulation of late endosome to lysosome transport inorganic ion homeostasis homeostatic process intracellular copper ion homeostasis copper ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis membrane organization vesicle localization establishment of organelle localization vesicle budding from membrane establishment of vesicle localization cellular component organization vesicle organization organelle organization organelle localization synaptic vesicle budding cellular component organization or biogenesis synaptic vesicle localization synaptic vesicle transport postsynapse organization actin cytoskeleton organization postsynaptic cytoskeleton organization cell junction organization postsynaptic actin cytoskeleton organization actin filament-based process synapse organization cytoskeleton organization positive regulation of cation transmembrane transport monoatomic ion transmembrane transport sodium ion transmembrane transport regulation of monoatomic ion transmembrane transport regulation of sodium ion transport metal ion transport regulation of sodium ion transmembrane transport positive regulation of sodium ion transport monoatomic cation transmembrane transport positive regulation of monoatomic ion transport positive regulation of sodium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of monoatomic ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport sodium ion transport protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization import into cell regulation of cellular component organization receptor internalization regulation of receptor-mediated endocytosis regulation of receptor internalization endocytosis receptor-mediated endocytosis regulation of endocytosis multicellular organismal process regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development cell development regulation of dendritic spine development neuron projection development positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development system development developmental process dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development cellular metabolic process regulation of lipid metabolic process regulation of phospholipid metabolic process regulation of cellular metabolic process primary metabolic process regulation of primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process cellular lipid metabolic process regulation of phosphorus metabolic process metabolic process phosphorus metabolic process regulation of metabolic process lipid metabolic process Golgi to transport vesicle transport intracellular protein transport regulation of protein localization positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport regulation of secretion by cell secretion by cell positive regulation of secretion secretion regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of protein localization dendritic spine organization neuron projection organization regulated exocytosis regulation of calcium ion-dependent exocytosis positive regulation of exocytosis regulation of regulated secretory pathway positive regulation of regulated secretory pathway calcium-ion regulated exocytosis positive regulation of calcium ion-dependent exocytosis exocytosis regulation of exocytosis very-low-density lipoprotein particle assembly plasma lipoprotein particle organization protein-containing complex organization protein-lipid complex organization regulation of plasma lipoprotein particle levels cellular component biogenesis cellular component assembly protein-containing complex assembly plasma lipoprotein particle assembly protein-lipid complex assembly negative regulation of signaling signaling modulation of chemical synaptic transmission negative regulation of biological process negative regulation of synaptic transmission negative regulation of cell communication cell communication synaptic signaling negative regulation of cellular process regulation of biological quality regulation of synaptic plasticity trans-synaptic signaling regulation of signaling cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling long-term synaptic depression anterograde trans-synaptic signaling regulation of cell communication lysosome organization vacuole organization lytic vacuole organization lysosomal membrane organization cytoskeleton-dependent cytokinesis mitotic cytokinetic process cleavage furrow ingression mitotic cytokinesis cytokinesis mitotic cleavage furrow ingression mitotic cell cycle mitotic cell cycle process cytokinetic process membrane invagination cell cycle cell division plasma membrane invagination cell cycle process regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin nucleation regulation of actin filament organization actin filament organization Arp2/3 complex-mediated actin nucleation regulation of organelle organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization actin nucleation supramolecular fiber organization positive regulation of cellular component organization positive regulation of endocytosis cellular response to virus biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus	cellular anatomical entity endomembrane system intracellular anatomical structure cytoplasm cytosol cell leading edge cell periphery plasma membrane membrane protein-containing complex synapse cell junction glutamatergic synapse cell projection cellular anatomical entity endomembrane system intracellular anatomical structure cytoplasm cytosol cell leading edge cell periphery plasma membrane membrane protein-containing complex synapse cell junction glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle membrane-bounded organelle Golgi apparatus intracellular membrane-bounded organelle Golgi membrane bounding membrane of organelle organelle membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse endosome intracellular vesicle cytoplasmic vesicle late endosome vesicle
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	RHO-GTPASE ACTIVATING PROTEIN 10	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell cellular process establishment of localization cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell cellular process establishment of localization cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction cellular component organization organelle organization cellular component organization or biogenesis Golgi organization endomembrane system organization maintenance of Golgi location maintenance of organelle location maintenance of location in cell maintenance of location organelle transport along microtubule transport intracellular transport microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane cell junction Golgi apparatus endomembrane system Golgi membrane bounding membrane of organelle cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytosol anchoring junction cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR045872	ADP-ribosylation factor 1-5	Family
A, B, C, D, E A, B, C, D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR005225	Small GTP-binding protein domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR006689	Small GTPase superfamily, ARF/SAR type	Family
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	IPR000198	Rho GTPase-activating protein domain	Domain
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	IPR001849	Pleckstrin homology domain	Domain
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	IPR041489	PDZ domain 6	Domain
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	IPR036034	PDZ superfamily	Homologous Superfamily
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	IPR011993	PH-like domain superfamily	Homologous Superfamily
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	IPR001478	PDZ domain	Domain
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	IPR008936	Rho GTPase activation protein	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], G [auth M], H [auth N], I [auth O], J [auth P], K [auth Q], L [auth R]	Pharos: Q5T5U3	age-related macular degeneration invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ductal breast carcinoma in situ osteosarcoma primitive neuroectodermal tumor interstitial lung disease ovarian cancer wet macular degeneration

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.