Annotations: 2J3T

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2j3ta_	Alpha and beta proteins (a+b)	Ligand-binding domain in the NO signalling and Golgi transport	Ligand-binding domain in the NO signalling and Golgi transport	TRAPP components	automated matches	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ligand-binding domain in the NO signalling and Golgi transport	8043404	3001668	SCOP2B (2022-06-29)
C	SCOP2 Family	Sybindin-like	8045360	4004434	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	SNARE-like	8090323	3001113	SCOP2 (2022-06-29)
D	SCOP2 Family	Sybindin-like	8045359	4004434	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	SNARE-like	8090322	3001113	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04051	e2j3tA1	A: a+b complex topology	X: H-NOX domain (From Topology)	H: H-NOX domain (From Topology)	T: H-NOX domain	F: PF04051	ECOD (1.6)
B	PF04051	e2j3tB1	A: a+b complex topology	X: H-NOX domain (From Topology)	H: H-NOX domain (From Topology)	T: H-NOX domain	F: PF04051	ECOD (1.6)
C	PF04099	e2j3tC1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF04099	ECOD (1.6)
D	F_UNCLASSIFIED	e2j3tD2	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF04099	e2j3tD1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: PF04099	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1380.20	Alpha Beta	2-Layer Sandwich	Muramoyl-pentapeptide Carboxypeptidase	domain 2	CATH (4.3.0)
B	3.30.1380.20	Alpha Beta	2-Layer Sandwich	Muramoyl-pentapeptide Carboxypeptidase	domain 2	CATH (4.3.0)
C	3.30.450.70	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)
D	3.30.450.70	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04051	Transport protein particle (TRAPP) component (TRAPP)	Transport protein particle (TRAPP) component	-	Family
B	PF04051	Transport protein particle (TRAPP) component (TRAPP)	Transport protein particle (TRAPP) component	-	Family
C	PF04099	Sybindin-like family (Sybindin)	Sybindin-like family	-	Family
D	PF04099	Sybindin-like family (Sybindin)	Sybindin-like family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3	-	localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport vesicle localization establishment of organelle localization cellular localization establishment of vesicle localization vesicle targeting cellular component organization organelle localization localization transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport intra-Golgi vesicle-mediated transport vesicle localization establishment of organelle localization cellular localization establishment of vesicle localization vesicle targeting cellular component organization organelle localization establishment of localization in cell cellular component organization or biogenesis vesicle tethering vesicle budding from membrane vesicle targeting, to, from or within Golgi vesicle organization cellular component biogenesis cellular component assembly protein-containing complex assembly vesicle coating vesicle targeting, rough ER to cis-Golgi membrane organization protein-containing complex organization intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport organelle organization COPII-coated vesicle budding COPII vesicle coating	membrane-bounded organelle intracellular anatomical structure cis-Golgi network membrane Golgi apparatus membrane intracellular membrane-bounded organelle cellular anatomical entity endomembrane system intracellular organelle bounding membrane of organelle cis-Golgi network organelle cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure cis-Golgi network membrane Golgi apparatus membrane intracellular membrane-bounded organelle cellular anatomical entity endomembrane system intracellular organelle bounding membrane of organelle cis-Golgi network organelle cytoplasm organelle membrane protein-containing complex intracellular protein-containing complex TRAPP complex vesicle tethering complex Golgi membrane endosome intracellular vesicle TRAPPII protein complex cytoplasmic vesicle vesicle TRAPPIII protein complex cytosol endoplasmic reticulum
B	TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6A	-	vesicle localization establishment of organelle localization cellular localization transport establishment of vesicle localization establishment of localization vesicle targeting vesicle-mediated transport cellular component organization localization organelle localization establishment of localization in cell cellular process cellular component organization or biogenesis vesicle localization establishment of organelle localization cellular localization transport establishment of vesicle localization establishment of localization vesicle targeting vesicle-mediated transport cellular component organization localization organelle localization establishment of localization in cell cellular process cellular component organization or biogenesis vesicle tethering vesicle budding from membrane vesicle targeting, to, from or within Golgi vesicle organization cellular component biogenesis cellular component assembly protein-containing complex assembly vesicle coating vesicle targeting, rough ER to cis-Golgi membrane organization protein-containing complex organization intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport organelle organization COPII-coated vesicle budding COPII vesicle coating Golgi vesicle transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus cis-Golgi network organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm endomembrane system Golgi apparatus subcompartment organelle subcompartment trans-Golgi network protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus cis-Golgi network organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm endomembrane system Golgi apparatus subcompartment organelle subcompartment trans-Golgi network protein-containing complex intracellular protein-containing complex TRAPP complex vesicle tethering complex TRAPPIII protein complex cytosol endoplasmic reticulum
C	TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1	-	establishment of organelle localization vesicle budding from membrane cellular localization transport vesicle targeting, to, from or within Golgi vesicle-mediated transport vesicle targeting cellular component organization vesicle organization cellular component biogenesis localization cellular component assembly organelle localization establishment of localization in cell protein-containing complex assembly establishment of organelle localization vesicle budding from membrane cellular localization transport vesicle targeting, to, from or within Golgi vesicle-mediated transport vesicle targeting cellular component organization vesicle organization cellular component biogenesis localization cellular component assembly organelle localization establishment of localization in cell protein-containing complex assembly vesicle coating cellular component organization or biogenesis vesicle targeting, rough ER to cis-Golgi membrane organization vesicle localization protein-containing complex organization establishment of vesicle localization intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization organelle organization cellular process COPII-coated vesicle budding COPII vesicle coating Golgi vesicle transport vesicle tethering	protein-containing complex intracellular protein-containing complex TRAPP complex vesicle tethering complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system Golgi apparatus protein-containing complex intracellular protein-containing complex TRAPP complex vesicle tethering complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system Golgi apparatus endosome intracellular vesicle TRAPPII protein complex cytoplasmic vesicle vesicle TRAPPIII protein complex
D	TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4	-	developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development cellular component organization generation of neurons neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development cellular component organization generation of neurons neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation neuron development anatomical structure development cellular process cellular component organization or biogenesis system development vesicle localization establishment of organelle localization cellular localization transport establishment of vesicle localization establishment of localization vesicle targeting vesicle-mediated transport localization organelle localization establishment of localization in cell vesicle tethering cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism vesicle budding from membrane vesicle targeting, to, from or within Golgi vesicle organization cellular component biogenesis cellular component assembly protein-containing complex assembly vesicle coating vesicle targeting, rough ER to cis-Golgi membrane organization protein-containing complex organization intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport organelle organization COPII-coated vesicle budding COPII vesicle coating Golgi vesicle transport	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle Golgi stack cytoplasm protein-containing complex intracellular protein-containing complex TRAPP complex vesicle tethering complex Golgi membrane bounding membrane of organelle organelle membrane endosome intracellular vesicle TRAPPII protein complex cytoplasmic vesicle vesicle TRAPPIII protein complex cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection transport vesicle presynapse synaptic vesicle secretory vesicle exocytic vesicle endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily	Homologous Superfamily
A	IPR007194	Transport protein particle (TRAPP) component	Family
A	IPR016721	Bet3 family	Family
B	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily	Homologous Superfamily
B	IPR007194	Transport protein particle (TRAPP) component	Family
B	IPR037992	TRAPP complex, Trs33 subunit	Family
C	IPR007233	Trafficking protein particle complex subunit	Family
C	IPR011012	Longin-like domain superfamily	Homologous Superfamily
D	IPR007233	Trafficking protein particle complex subunit	Family
D	IPR011012	Longin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: O75865	breast cancer intellectual disability ulcerative colitis cutaneous lupus erythematosus psoriasis heart disease tuberculosis
D	Pharos: Q9Y296	heart disease lymphoplasmacytic lymphoma plasma cell myeloma large cell medulloblastoma osteosarcoma lung carcinoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.