Annotations: 2IX7

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ix7a_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	automated matches	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d2ix7b_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	automated matches	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00036	e2ix7A3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
A	PF13499	e2ix7A2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
B	PF00036	e2ix7B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
B	PF13499	e2ix7B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.20.5.190	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (utative)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C	PF00612	IQ calmodulin-binding motif (IQ)	IQ calmodulin-binding motif	-	Motif
A, B	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C	MYOSIN-5A	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding cytoskeletal motor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding cytoskeletal motor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding identical protein binding cation binding calcium ion binding metal ion binding syntaxin-1 binding SNARE binding syntaxin binding ATP-dependent protein binding kinase binding protein kinase binding calcium-dependent protein binding disordered domain specific binding protein domain specific binding microfilament motor activity ATP-dependent activity	vesicle localization localization organelle localization secretory granule localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization vesicle localization localization organelle localization secretory granule localization post-Golgi vesicle-mediated transport transport cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane pigment metabolic process organic hydroxy compound metabolic process pigment biosynthetic process melanin metabolic process secondary metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process secondary metabolite biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process phenol-containing compound biosynthetic process metabolic process melanin biosynthetic process monoamine transport nitrogen compound transport negative regulation of amine transport signaling regulation of catecholamine secretion negative regulation of biological process negative regulation of transport organic hydroxy compound transport dopamine transport cell communication secretion by cell regulation of secretion by cell negative regulation of secretion catecholamine transport negative regulation of dopamine secretion signal release negative regulation of cellular process negative regulation of secretion by cell secretion regulation of transport organic substance transport export from cell cell-cell signaling negative regulation of catecholamine secretion dopamine secretion regulation of secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion organonitrogen compound metabolic process dopamine metabolic process catechol-containing compound metabolic process amine metabolic process catecholamine metabolic process biogenic amine metabolic process pigmentation developmental pigmentation developmental process anatomical structure morphogenesis odontogenesis animal organ development anatomical structure development animal organ morphogenesis establishment of organelle localization establishment of melanosome localization establishment of vesicle localization cellular pigmentation pigment granule transport establishment of pigment granule localization pigment granule localization establishment of localization in cell melanosome transport melanosome localization negative regulation of signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission negative regulation of cell communication synaptic signaling trans-synaptic signaling regulation of signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication negative regulation of synaptic transmission, glutamatergic cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization actin filament-based movement establishment of protein localization hormone secretion protein localization to extracellular region peptide secretion amide transport regulation of biological quality regulation of hormone levels establishment of protein localization to extracellular region protein secretion peptide transport protein transport peptide hormone secretion hormone transport insulin secretion response to stimulus defense response response to stress reactive gliosis inflammatory response neuroinflammatory response cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly protein transport along microtubule microtubule-based protein transport transport along microtubule axo-dendritic protein transport intracellular transport axo-dendritic transport microtubule-based transport microtubule-based process cytoskeleton-dependent intracellular transport microtubule-based movement intracellular protein transport inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of postsynaptic cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis pigment cell differentiation cellular developmental process cell differentiation melanocyte differentiation establishment of ER localization endoplasmic reticulum localization endoplasmic reticulum organization establishment of endoplasmic reticulum localization to postsynapse endomembrane system organization cellular response to stimulus cellular response to nitrogen compound response to organic substance response to peptide hormone regulation of cellular response to insulin stimulus positive regulation of response to stimulus cellular response to endogenous stimulus response to hormone cellular response to organic substance positive regulation of cellular response to insulin stimulus cellular response to hormone stimulus response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound regulation of response to stimulus response to chemical response to insulin cellular response to insulin stimulus cell junction organization synapse organization regulation of vascular associated smooth muscle cell migration positive regulation of locomotion vascular associated smooth muscle cell migration regulation of cell motility regulation of smooth muscle cell migration positive regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of vascular associated smooth muscle cell migration cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy process utilizing autophagic mechanism multicellular organismal process epithelium development epidermis development molting cycle process hair cycle developmental maturation tissue development skin development anatomical structure maturation skin epidermis development hair follicle development molting cycle hair cycle process hair follicle maturation sensory perception of light stimulus system process sensory perception nervous system process visual perception regulation of vesicle-mediated transport exocytosis regulation of exocytosis behavior locomotory behavior locomotion involved in locomotory behavior myelination multicellular organism development axon ensheathment ensheathment of neurons nervous system development system development vesicle transport along actin filament vesicle cytoskeletal trafficking actin filament-based transport oxoacid metabolic process cellular biosynthetic process long-chain fatty acid biosynthetic process lipid biosynthetic process organic acid metabolic process organic acid biosynthetic process carboxylic acid biosynthetic process small molecule metabolic process fatty acid metabolic process long-chain fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process cellular lipid metabolic process monocarboxylic acid metabolic process lipid metabolic process	membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton actomyosin non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle intracellular vesicle membrane cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton actomyosin non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle endoplasmic reticulum smooth endoplasmic reticulum somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex myosin complex synapse cell junction glutamatergic synapse non-motile cilium 9+0 non-motile cilium cilium photoreceptor outer segment photoreceptor cell cilium unconventional myosin complex Golgi apparatus endosome recycling endosome ruffle cell leading edge cell body neuronal cell body axon actomyosin, myosin complex part insulin-responsive compartment postsynapse transport vesicle presynapse synaptic vesicle exocytic vesicle postsynaptic cytoskeleton postsynaptic actin cytoskeleton pigment granule melanosome polymeric cytoskeletal fiber intermediate filament cytoskeleton intermediate filament supramolecular fiber supramolecular polymer supramolecular complex filopodium tip actin-based cell projection filopodium Schaffer collateral - CA1 synapse ribonucleoprotein complex
A, B	CALMODULIN	cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity enzyme binding adenylate cyclase binding cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity enzyme binding adenylate cyclase binding phosphatidylinositol 3-kinase binding nitric-oxide synthase regulator activity molecular function inhibitor activity channel regulator activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity ion channel regulator activity calcium channel regulator activity transporter regulator activity channel inhibitor activity cyclase regulator activity cyclase activator activity adenylate cyclase regulator activity adenylate cyclase activator activity protein serine/threonine kinase activator activity kinase activator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity nitric-oxide synthase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein domain specific binding signaling receptor binding type 3 metabotropic glutamate receptor binding glutamate receptor binding G protein-coupled receptor binding G protein-coupled glutamate receptor binding transmembrane transporter binding kinase binding protein kinase binding calcium-dependent protein binding	organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity intracellular calcium ion homeostasis negative regulation of biological process negative regulation of ryanodine-sensitive calcium-release channel activity negative regulation of transport calcium ion transport negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport regulation of molecular function release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis transport negative regulation of cation channel activity homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport positive regulation of biological process regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport regulation of transporter activity maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis negative regulation of cellular process monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion positive regulation of cellular process regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion negative regulation of transporter activity negative regulation of molecular function negative regulation of calcium ion transport cellular homeostasis regulation of ryanodine-sensitive calcium-release channel activity regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cellular component disassembly catabolic process macroautophagy protein-containing complex organization cellular metabolic process autophagy protein-containing complex disassembly cellular catabolic process cellular component organization autophagosome maturation autophagosome membrane docking metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism cellular response to stimulus response to interferon-beta response to organic substance response to cytokine cellular response to interferon-beta cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process mitochondrion-endoplasmic reticulum membrane tethering cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition mitotic cell cycle mitotic cell cycle phase transition regulation of cardiac muscle contraction cardiac muscle contraction muscle contraction muscle system process regulation of muscle system process striated muscle contraction regulation of striated muscle contraction regulation of muscle contraction biological process involved in interspecies interaction between organisms response to type II interferon cellular response to type II interferon response to biotic stimulus response to stress innate immune response response to external biotic stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus immune system process defense response to other organism positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction signaling positive regulation of receptor signaling pathway via STAT regulation of signal transduction positive regulation of receptor signaling pathway via JAK-STAT cell communication positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT signal transduction regulation of signaling cell surface receptor signaling pathway regulation of response to stimulus regulation of cell communication regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling regulation of action potential regulation of cardiac muscle cell action potential action potential cardiac muscle cell action potential regulation of membrane potential protein dephosphorylation regulation of protein modification process positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process protein modification process phosphorus metabolic process organonitrogen compound metabolic process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of protein dephosphorylation regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process detection of stimulus detection of chemical stimulus detection of calcium ion	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle cell projection intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection protein-containing complex transmembrane transporter complex membrane membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex myelin sheath centrosome microtubule organizing center catalytic complex growth cone axon distal axon neuron projection site of polarized growth nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen voltage-gated potassium channel complex plasma membrane protein complex plasma membrane potassium channel complex cell periphery polymeric cytoskeletal fiber spindle microtubule microtubule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C	IPR002710	Dilute domain	Domain
C	IPR000048	IQ motif, EF-hand binding site	Binding Site
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR004009	Myosin, N-terminal, SH3-like	Domain
C	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
C	IPR036103	Class V myosin, motor domain	Domain
C	IPR037988	Myosin 5a, cargo-binding domain	Domain
C	IPR001609	Myosin head, motor domain	Domain
A, B	IPR002048	EF-hand domain	Domain
A, B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.