2IUI

Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2iuib1	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	SH2 domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2iuib2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2iuia1	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	SH2 domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2iuia2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	SH2 domain	8052378	3000197	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SH2 domain	8052378	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00017	e2iuiB1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF00017	ECOD (1.6)
A	PF00017	e2iuiA1	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: PF00017	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain
A, B	PF16454	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain (PI3K_P85_iSH2)	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain	This domain is found between the two SH2 domains in phosphatidylinositol 3-kinase regulatory subunit P85. It forms a complex with the adaptor-binding domain of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha [1].	Domain
C, D	PF07714	Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)	Protein tyrosine and serine/threonine kinase	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Phosphatidylinositol 3-kinase regulatory subunit alpha	protein binding binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity protein binding binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase regulator activity phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding protein phosphatase binding phosphatase binding enzyme binding neurotrophin TRK receptor binding neurotrophin TRKA receptor binding cytokine receptor binding neurotrophin receptor binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase activator activity insulin-like growth factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding receptor tyrosine kinase binding protein kinase binding molecular adaptor activity signaling adaptor activity signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity protein dimerization activity phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups phosphatidylinositol 3-kinase regulatory subunit binding enzyme-substrate adaptor activity ErbB-3 class receptor binding	cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular process cellular response to organic substance signal transduction cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis regulation of protein stability regulation of biological quality protein stabilization positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport myeloid leukocyte differentiation regulation of leukocyte differentiation multicellular organismal process cellular developmental process regulation of developmental process negative regulation of biological process cell development regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation multicellular organism development cell differentiation osteoclast differentiation anatomical structure development negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process immune system process regulation of hemopoiesis negative regulation of multicellular organismal process leukocyte differentiation insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation T cell differentiation positive regulation of establishment of protein localization regulation of intracellular transport positive regulation of protein localization to nucleus positive regulation of protein import into nucleus regulation of nucleocytoplasmic transport regulation of intracellular protein transport positive regulation of intracellular protein transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport extrinsic apoptotic signaling pathway via death domain receptors cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus growth hormone receptor signaling pathway response to endogenous stimulus response to organonitrogen compound cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to organonitrogen compound cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation cellular component disassembly regulation of focal adhesion disassembly regulation of cellular component organization positive regulation of cellular component organization focal adhesion disassembly cell junction disassembly cell-substrate junction disassembly positive regulation of cell-substrate junction organization cellular component organization cell junction organization positive regulation of focal adhesion disassembly cell-substrate junction organization regulation of cell-substrate junction organization cellular component organization or biogenesis positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to stress response to stress response to endoplasmic reticulum stress B cell activation B cell differentiation immune response intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly cellular component biogenesis cellular component assembly actin filament bundle organization actin filament-based process stress fiber assembly negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly organelle organization negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process lipid metabolic process RNA processing RNA splicing regulation of RNA splicing positive regulation of gene expression positive regulation of RNA splicing positive regulation of locomotion regulation of cell motility regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of cell migration leukocyte migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility positive regulation of immune system process locomotion DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway insulin receptor signaling pathway response to insulin cellular response to insulin stimulus response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV regulation of cell-substrate adhesion regulation of cell adhesion negative regulation of cell-matrix adhesion negative regulation of cell adhesion cell-matrix adhesion regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion myeloid leukocyte migration filopodium assembly cell projection organization regulation of filopodium assembly plasma membrane bounded cell projection assembly positive regulation of cell projection organization positive regulation of filopodium assembly plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway pattern recognition receptor signaling pathway regulation of signal transduction response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response cell surface toll-like receptor signaling pathway innate immune response-activating signaling pathway response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus regulation of toll-like receptor 4 signaling pathway regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response response to external biotic stimulus cell surface pattern recognition receptor signaling pathway regulation of signaling positive regulation of innate immune response defense response defense response to symbiont toll-like receptor 4 signaling pathway regulation of cell communication regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production cytokine production regulation of cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production positive regulation of multicellular organismal process positive regulation of cytokine production cellular response to interleukin-18 response to interleukin-18 interleukin-18-mediated signaling pathway hexose transmembrane transport glucose import carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport regulation of lamellipodium assembly regulation of lamellipodium organization lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization lamellipodium organization positive regulation of cell communication positive regulation of signal transduction regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress regulation of endoplasmic reticulum unfolded protein response positive regulation of response to endoplasmic reticulum stress positive regulation of endoplasmic reticulum unfolded protein response cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein response to topologically incorrect protein positive regulation of signaling	membrane cellular anatomical entity cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex membrane cellular anatomical entity cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane membrane-bounded organelle intracellular organelle Golgi apparatus cis-Golgi network organelle intracellular membrane-bounded organelle endomembrane system perinuclear endoplasmic reticulum membrane organelle subcompartment endoplasmic reticulum subcompartment perinuclear endoplasmic reticulum nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cell periphery plasma membrane nucleus
C, D	Platelet-derived growth factor receptor beta	protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity platelet-derived growth factor receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity platelet-derived growth factor receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding platelet-derived growth factor beta-receptor activity platelet-derived growth factor binding growth factor binding platelet activating factor receptor activity G protein-coupled receptor activity kinase binding enzyme binding protein kinase binding vascular endothelial growth factor binding	multicellular organismal process angiogenesis multicellular organism development tube morphogenesis anatomical structure development cell migration cell motility blood vessel development system development developmental process heart development angiogenesis involved in coronary vascular morphogenesis blood vessel morphogenesis tube development multicellular organismal process angiogenesis multicellular organism development tube morphogenesis anatomical structure development cell migration cell motility blood vessel development system development developmental process heart development angiogenesis involved in coronary vascular morphogenesis blood vessel morphogenesis tube development animal organ development cell migration involved in heart development coronary vasculature development vasculature development circulatory system development anatomical structure morphogenesis anatomical structure formation involved in morphogenesis cell migration involved in coronary angiogenesis cellular process coronary vasculature morphogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication positive regulation of signaling positive regulation of phosphoprotein phosphatase activity protein dephosphorylation regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation cellular metabolic process dephosphorylation regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of hydrolase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process positive regulation of protein metabolic process positive regulation of cellular metabolic process regulation of phosphoprotein phosphatase activity positive regulation of molecular function positive regulation of protein modification process organic substance metabolic process protein metabolic process organonitrogen compound metabolic process regulation of protein dephosphorylation positive regulation of catalytic activity positive regulation of protein dephosphorylation regulation of macromolecule metabolic process positive regulation of hydrolase activity cell migration involved in vasculogenesis cellular developmental process vasculogenesis cell differentiation metanephric glomerulus vasculature development connective tissue development metanephric glomerulus development renal system development kidney vasculature development renal system vasculature development metanephros development metanephric glomerular mesangial cell proliferation involved in metanephros development nephron development metanephric nephron development cell population proliferation cell proliferation involved in kidney development glomerular mesangium development tissue development glomerulus development metanephric glomerular mesangium development cell proliferation involved in metanephros development glomerular mesangial cell proliferation glomerulus vasculature development kidney development platelet-derived growth factor receptor-beta signaling pathway cell surface receptor signaling pathway platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway chemotaxis positive regulation of locomotion regulation of response to external stimulus response to external stimulus regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to external stimulus taxis response to chemical regulation of locomotion locomotion cellular response to growth factor stimulus positive regulation of cell population proliferation positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway cellular response to endogenous stimulus VEGF-activated platelet-derived growth factor receptor signaling pathway response to endogenous stimulus vascular endothelial growth factor signaling pathway regulation of cell population proliferation cellular response to vascular endothelial growth factor stimulus response to growth factor glomerulus vasculature morphogenesis glomerular capillary formation metanephric glomerulus morphogenesis metanephric glomerulus vasculature morphogenesis glomerulus morphogenesis kidney vasculature morphogenesis metanephric glomerular capillary formation renal system vasculature morphogenesis regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration positive regulation of cell motility regulation of cell migration positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division protein phosphorylation protein autophosphorylation phosphorylation cell chemotaxis cellular response to chemical stimulus smooth muscle cell chemotaxis regulation of calcium ion import regulation of calcium ion transport regulation of localization positive regulation of calcium ion transport positive regulation of calcium ion import transport regulation of transport regulation of monoatomic ion transport establishment of localization calcium ion transport metal ion transport localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation sensory organ development retina vasculature development in camera-type eye eye development retina development in camera-type eye visual system development camera-type eye development sensory system development positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade aorta morphogenesis artery development aorta development artery morphogenesis regulation of metanephric mesenchymal cell migration positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway cell migration involved in kidney development cell migration involved in metanephros development positive regulation of metanephric mesenchymal cell migration metanephric mesenchymal cell migration regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process peptidyl-tyrosine modification peptidyl-amino acid modification peptidyl-tyrosine phosphorylation positive regulation of phosphorylation regulation of transferase activity regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of protein phosphorylation positive regulation of MAP kinase activity positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of protein phosphorylation positive regulation of protein kinase activity positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation regulation of phospholipase activity positive regulation of phospholipase activity positive regulation of phospholipase C activity positive regulation of lipase activity regulation of phospholipase C activity regulation of lipase activity cardiac muscle cell development cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation striated muscle tissue development cellular component biogenesis muscle structure development striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development cardiac cell development muscle tissue development actomyosin structure organization organelle assembly cardiac muscle tissue development cardiac muscle cell differentiation cardiocyte differentiation myofibril assembly cardiac myofibril assembly striated muscle cell differentiation supramolecular fiber organization cellular biosynthetic process regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process positive regulation of biosynthetic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of DNA biosynthetic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process positive regulation of DNA metabolic process biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process DNA biosynthetic process positive regulation of cellular biosynthetic process regulation of DNA metabolic process phosphatidylinositol metabolic process glycerophospholipid metabolic process phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process glycerolipid metabolic process lipid metabolic process	membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex receptor complex membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system anchoring junction cell junction membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex receptor complex membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system anchoring junction cell junction focal adhesion cell-substrate junction cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole lysosomal lumen intracellular organelle lumen organelle lumen lysosome cytoplasmic vesicle intracellular vesicle vesicle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A, B	IPR035020	PI3K p85 subunit, C-terminal SH2 domain	Domain
A, B	IPR035591	Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain	Domain
A, B	IPR032498	PI3K regulatory subunit p85-related , inter-SH2 domain	Domain
A, B	IPR001452	SH3 domain	Domain
A, B	IPR035022	PI3K p85 subunit, N-terminal SH2 domain	Domain
A, B	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B	IPR000980	SH2 domain	Domain
A, B	IPR000198	Rho GTPase-activating protein domain	Domain
A, B	IPR044124	PIK3R1, inter-SH2 domain	Domain
C, D	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site	Conserved Site
C, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C, D	IPR008266	Tyrosine-protein kinase, active site	Active Site
C, D	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
C, D	IPR000719	Protein kinase domain	Domain
C, D	IPR027288	Platelet-derived growth factor receptor beta	Family
C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C, D	IPR013151	Immunoglobulin	Domain
C, D	IPR007110	Immunoglobulin-like domain	Domain
C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
C, D	IPR003599	Immunoglobulin subtype	Domain
C, D	IPR003598	Immunoglobulin subtype 2	Domain
C, D	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P27986	SHORT syndrome immunodeficiency 36 agammaglobulinemia 7, autosomal recessive Burkitt lymphoma cancer prostate cancer glioblastoma Insulin Resistance carcinoma sarcomatoid carcinoma primitive neuroectodermal tumor dermatomyositis psoriasis Gaucher disease vitiligo SHORT syndrome immunodeficiency 36 agammaglobulinemia 7, autosomal recessive Burkitt lymphoma cancer prostate cancer glioblastoma Insulin Resistance carcinoma sarcomatoid carcinoma primitive neuroectodermal tumor dermatomyositis psoriasis Gaucher disease vitiligo intellectual disability juvenile dermatomyositis agammaglobulinemia lung cancer medulloblastoma atypical teratoid rhabdoid tumor oligodendroglioma breast cancer ovarian carcinoma Pick disease colorectal adenocarcinoma ductal breast carcinoma in situ rheumatoid arthritis tuberculosis interstitial cystitis activated PI3K-delta syndrome large cell medulloblastoma mammary neoplasms, animal autosomal agammaglobulinemia osteosarcoma breast carcinoma ovarian neoplasm pituitary cancer cystic fibrosis exocrine pancreatic carcinoma glioma undifferentiated carcinoma invasive ductal breast carcinoma lung adenocarcinoma malignant pancreatic neoplasm atrial fibrillation non-small cell lung carcinoma autosomal recessive agammaglobulinemia 1 ovarian cancer Parkinson disease
C, D	Pharos: P09619	skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome acroosteolysis-keloid-like lesions-premature aging syndrome myeloproliferative disorder, chronic, with eosinophilia infantile myofibromatosis basal ganglia calcification, idiopathic, 4 myofibromatosis, infantile, 1 chronic myelomonocytic leukemia Liver Cirrhosis, Experimental calcinosis basal ganglia disease cancer basal ganglia calcification, idiopathic, 1 bilateral striopallidodentate calcinosis gastric adenocarcinoma hepatocellular carcinoma skeletal overgrowth-craniofacial dysmorphism-hyperelastic skin-white matter lesions syndrome acroosteolysis-keloid-like lesions-premature aging syndrome myeloproliferative disorder, chronic, with eosinophilia infantile myofibromatosis basal ganglia calcification, idiopathic, 4 myofibromatosis, infantile, 1 chronic myelomonocytic leukemia Liver Cirrhosis, Experimental calcinosis basal ganglia disease cancer basal ganglia calcification, idiopathic, 1 bilateral striopallidodentate calcinosis gastric adenocarcinoma hepatocellular carcinoma interstitial cystitis invasive ductal breast carcinoma chronic eosinophilic leukemia pancreatic ductal adenocarcinoma dermatofibrosarcoma protuberans schizoaffective disorder gastric carcinoma systemic mastocytosis idiopathic hypereosinophilic syndrome ulcerative colitis acute myeloid leukemia juvenile myelomonocytic leukemia malignant mesothelioma bone marrow neoplasm myeloproliferative neoplasm colorectal cancer renal cell carcinoma schizophrenia gastrointestinal stromal tumor transitional cell carcinoma idiopathic pulmonary fibrosis intellectual disability interstitial lung disease malignant pancreatic neoplasm breast cancer myeloproliferative neoplasm, unclassifiable non-small cell lung carcinoma cystic fibrosis