Annotations: 2IFS

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8043646	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00568	e2ifsA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF00568	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00568	WH1 domain (WH1)	WH1 domain	WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bi ...	WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue [2]. A subset of WH1 domains has been termed a "EVH1" domain [3] and appear to bind a polyproline motif.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Wiskott-Aldrich Syndrome Protein interacting protein and Neural Wiskott-Aldrich syndrome protein chimera	cytoskeletal protein binding protein binding binding actin binding identical protein binding	membrane organization cellular component organization membrane invagination cellular process cellular component organization or biogenesis postsynapse organization actin cytoskeleton organization postsynaptic cytoskeleton organization organelle organization cell junction organization postsynaptic actin cytoskeleton organization actin filament-based process synapse organization cytoskeleton organization membrane organization cellular component organization membrane invagination cellular process cellular component organization or biogenesis postsynapse organization actin cytoskeleton organization postsynaptic cytoskeleton organization organelle organization cell junction organization postsynaptic actin cytoskeleton organization actin filament-based process synapse organization cytoskeleton organization cell division plasma membrane tubulation regulation of biological process regulation of cellular component organization regulation of cellular process negative regulation of cellular component organization biological regulation negative regulation of biological process negative regulation of membrane tubulation regulation of plasma membrane organization plasma membrane organization negative regulation of cellular process endomembrane system organization regulation of membrane tubulation chemotaxis positive regulation of locomotion response to stimulus regulation of response to external stimulus positive regulation of biological process response to external stimulus regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to stimulus positive regulation of response to external stimulus taxis regulation of response to stimulus response to chemical regulation of locomotion locomotion protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization actin filament organization cellular component biogenesis cellular component assembly protein-containing complex assembly supramolecular fiber organization localization protein-containing complex localization negative regulation of mononuclear cell migration negative regulation of locomotion regulation of cell motility regulation of lymphocyte migration regulation of cell migration cell migration regulation of immune system process negative regulation of lymphocyte migration cell motility regulation of mononuclear cell migration negative regulation of cell migration regulation of leukocyte migration lymphocyte migration leukocyte migration negative regulation of leukocyte migration negative regulation of immune system process immune system process mononuclear cell migration negative regulation of cell motility vesicle budding from membrane transport establishment of localization vesicle-mediated transport vesicle organization cell projection organization regulation of cell projection assembly regulation of cell projection organization regulation of cellular component biogenesis cell projection assembly protein localization regulation of localization cellular localization regulation of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external biotic stimulus response to biotic stimulus multicellular organismal process cellular developmental process plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development dendritic spine morphogenesis system development developmental process dendritic spine development plasma membrane bounded cell projection organization dendritic spine organization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development neuron projection organization filopodium assembly positive regulation of cellular component organization regulation of filopodium assembly plasma membrane bounded cell projection assembly positive regulation of cell projection organization positive regulation of filopodium assembly positive regulation of cellular process positive regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly vesicle transport along actin filament vesicle cytoskeletal trafficking vesicle localization establishment of organelle localization establishment of vesicle localization intracellular transport actin filament-based movement organelle localization establishment of localization in cell cytoskeleton-dependent intracellular transport actin filament-based transport positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of postsynapse organization regulation of synapse organization regulation of synapse structure or activity regulation of biological quality import into cell positive regulation of endocytosis clathrin-dependent endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of transport positive regulation of clathrin-dependent endocytosis receptor-mediated endocytosis endocytosis regulation of clathrin-dependent endocytosis spindle localization cell cycle cell cycle process	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell cortex cortical cytoskeleton actin cytoskeleton intracellular organelle cell periphery actin cap cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol cell cortex cortical cytoskeleton actin cytoskeleton intracellular organelle cell periphery actin cap cytoskeleton organelle intracellular non-membrane-bounded organelle cortical actin cytoskeleton non-membrane-bounded organelle synapse cell junction glutamatergic synapse membrane-bounded organelle cytoplasmic vesicle intracellular vesicle intracellular membrane-bounded organelle vesicle Golgi membrane Golgi apparatus membrane endomembrane system bounding membrane of organelle organelle membrane postsynapse nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000095	CRIB domain	Domain
A	IPR000697	WH1/EVH1 domain	Domain
A	IPR036936	CRIB domain superfamily	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR003124	WH2 domain	Domain
A	IPR011026	Actin nucleation-promoting factor WAS, C-terminal	Homologous Superfamily
A	IPR033927	WASP family, EVH1 domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.