2IFG

Structure of the extracellular segment of human TRKA in complex with nerve growth factor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ifga1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	High affinity nerve growth factor receptor TrkA, different domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2ifga3	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	L domain-like	Ngr ectodomain-like	High affinity nerve growth factor receptor, N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ifgb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	I set domains	High affinity nerve growth factor receptor TrkA, different domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ifgb3	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	L domain-like	Ngr ectodomain-like	High affinity nerve growth factor receptor, N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth E]	d2ifge1	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Neurotrophin	beta-Nerve growth factor	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth F]	d2ifgf1	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Neurotrophin	beta-Nerve growth factor	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	I set domains	8054810	4007543	SCOP2 (2022-06-29)
A	SCOP2 Family	I set domains	8055581	4007543	SCOP2 (2022-06-29)
A	SCOP2 Family	Ngr ectodomain-like	8030338	4002278	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8054811	3000071	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Immunoglobulin (Ig) domain-like	8055582	3000071	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	L domain-like	8042717	3001010	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055582	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	L domain-like	8042717	3001010	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054811	3000071	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	Cystine-knot cytokines	8038796	3000846	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	Cystine-knot cytokines	8038796	3000846	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	I-set_10	e2ifgA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_10	ECOD (1.6)
A	I-set_11	e2ifgA4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_11	ECOD (1.6)
A	LRR_8_1	e2ifgA2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
B	I-set_10	e2ifgB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_10	ECOD (1.6)
B	I-set_11	e2ifgB4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_11	ECOD (1.6)
B	LRR_8_1	e2ifgB2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
C [auth E]	NGF	e2ifgE1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: NGF	ECOD (1.6)
D [auth F]	NGF	e2ifgF1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: NGF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth E]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
D [auth F]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF16920	Leucine rich repeat C-terminal motif (LRRCT_2)	Leucine rich repeat C-terminal motif	-	Motif
C [auth E], D [auth F]	PF00243	Nerve growth factor family (NGF)	Nerve growth factor family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	High affinity nerve growth factor receptor	molecular transducer activity catalytic activity, acting on a protein GPI-linked ephrin receptor activity ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity molecular transducer activity catalytic activity, acting on a protein GPI-linked ephrin receptor activity ephrin receptor activity kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity neurotrophin binding protein binding binding nerve growth factor binding growth factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding signaling receptor binding cytokine receptor binding neurotrophin receptor binding neurotrophin p75 receptor binding neurotrophin receptor activity nerve growth factor receptor activity identical protein binding kinase binding enzyme binding protein homodimerization activity protein dimerization activity	response to stimulus response to chemical response to xenobiotic stimulus organonitrogen compound metabolic process protein phosphorylation protein autophosphorylation phosphorylation cellular metabolic process primary metabolic process peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation organic substance metabolic process macromolecule modification peptidyl-amino acid modification response to stimulus response to chemical response to xenobiotic stimulus organonitrogen compound metabolic process protein phosphorylation protein autophosphorylation phosphorylation cellular metabolic process primary metabolic process peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation organic substance metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process peptidyl-tyrosine phosphorylation protein modification process phosphorus metabolic process response to stress response to wounding response to axon injury developmental process multicellular organism development multicellular organismal process anatomical structure development sympathetic nervous system development autonomic nervous system development nervous system development system development cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor regulation of neuron projection development regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis neuron differentiation positive regulation of neuron projection development cell differentiation positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation generation of neurons neuron development regulation of plasma membrane bounded cell projection organization response to electrical stimulus response to abiotic stimulus detection of external stimulus system process detection of stimulus involved in sensory perception of pain nervous system process response to external stimulus sensory perception of temperature stimulus sensory perception of pain detection of temperature stimulus involved in sensory perception response to temperature stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of temperature stimulus detection of stimulus involved in sensory perception detection of temperature stimulus involved in sensory perception of pain positive regulation of DNA-binding transcription factor activity cellular biosynthetic process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process programmed cell death involved in cell development cell death programmed cell death response to nutrient levels reproductive process sex differentiation developmental process involved in reproduction epithelial cell differentiation Sertoli cell differentiation male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development epithelium development gonad development reproductive system development Sertoli cell development animal organ development tissue development epithelial cell development cellular response to stimulus cell surface receptor signaling pathway signaling cell communication nerve growth factor signaling pathway neurotrophin signaling pathway signal transduction rhythmic process circadian rhythm hemopoiesis B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation immune system process leukocyte differentiation positive regulation of nervous system development regulation of developmental process regulation of nervous system development positive regulation of developmental process cellular component biogenesis cellular component assembly cell junction assembly regulation of multicellular organismal process regulation of synapse structure or activity synapse organization regulation of synapse assembly regulation of biological quality regulation of multicellular organismal development positive regulation of cellular component biogenesis regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly detection of mechanical stimulus involved in sensory perception of pain response to mechanical stimulus detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of mechanical stimulus positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic synaptic signaling trans-synaptic signaling positive regulation of synaptic transmission cell-cell signaling positive regulation of synaptic transmission, glutamatergic chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity mechanoreceptor differentiation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process olfactory nerve development nerve development cranial nerve development cellular response to chemical stimulus cellular response to nicotine response to nicotine axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis axon guidance axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron projection guidance negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis behavior learning or memory cognition neurotrophin TRK receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of programmed cell death multicellular organismal response to stress response to pain behavioral response to formalin induced pain chemosensory behavior behavioral response to chemical pain behavioral response to pain positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process regulation of phosphorus metabolic process regulation of phosphorylation response to acid chemical response to hydrostatic pressure response to oxygen-containing compound response to water response to inorganic substance innervation axonogenesis involved in innervation small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction Ras protein signal transduction positive regulation of small GTPase mediated signal transduction	somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection membrane-bounded organelle endosome membrane intracellular anatomical structure endosome membrane intracellular vesicle late endosome membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection membrane-bounded organelle endosome membrane intracellular anatomical structure endosome membrane intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle late endosome cytoplasm vesicle organelle membrane protein-containing complex receptor complex cell body neuronal cell body axon cell surface cell periphery plasma membrane early endosome recycling endosome recycling endosome membrane early endosome membrane
C [auth E], D [auth F]	Beta-nerve growth factor	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity nerve growth factor receptor binding cytokine receptor binding neurotrophin receptor binding tumor necrosis factor receptor superfamily binding death receptor binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity nerve growth factor receptor binding cytokine receptor binding neurotrophin receptor binding tumor necrosis factor receptor superfamily binding death receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity metalloendopeptidase inhibitor activity endopeptidase inhibitor activity lipid binding	regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding cellular response to stimulus regulation of biological process cellular response to growth factor stimulus regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding cellular response to stimulus regulation of biological process cellular response to growth factor stimulus regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling response to endogenous stimulus cellular response to nerve growth factor stimulus cell communication cellular response to endogenous stimulus nerve growth factor signaling pathway neurotrophin signaling pathway response to nerve growth factor cellular process response to growth factor signal transduction cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation behavior multicellular organismal process system process learning or memory nervous system process cognition memory neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of neuron apoptotic process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization nervous system development generation of neurons anatomical structure morphogenesis neuron development extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway apoptotic signaling pathway trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of developmental process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of neuron differentiation negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation peripheral nervous system development positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth regulation of neurogenesis regulation of cell development positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth positive regulation of collateral sprouting regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis positive regulation of multicellular organismal process regulation of neuron projection development regulation of collateral sprouting regulation of cellular component organization positive regulation of cellular component organization cell growth regulation of nervous system development regulation of extent of cell growth regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis positive regulation of axonogenesis regulation of cell size regulation of multicellular organismal development collateral sprouting regulation of developmental growth developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation positive regulation of growth regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size nerve development positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of Ras protein signal transduction intracellular signaling cassette positive regulation of Ras protein signal transduction Ras protein signal transduction positive regulation of intracellular signal transduction regulation of response to stimulus positive regulation of small GTPase mediated signal transduction positive regulation of signaling cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle extracellular region axon extracellular space endosome intracellular vesicle cytoplasmic vesicle endosome lumen vesicle transport vesicle synapse presynapse synaptic vesicle cell junction secretory vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR020777	Growth factor receptor NTRK	Family
A, B	IPR031635	Growth factor receptor NTRK, leucine rich repeat C-terminal	Domain
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A, B	IPR007110	Immunoglobulin-like domain	Domain
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR040665	Tyrosine kinase receptor A, transmembrane domain	Domain
A, B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR020461	High affinity nerve growth factor receptor NTRK1	Family
C [auth E], D [auth F]	IPR020408	Nerve growth factor-like	Family
C [auth E], D [auth F]	IPR019846	Nerve growth factor conserved site	Conserved Site
C [auth E], D [auth F]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
C [auth E], D [auth F]	IPR020437	Nerve growth factor, beta subunit, mammalian	Family
C [auth E], D [auth F]	IPR002072	Nerve growth factor-related	Domain
C [auth E], D [auth F]	IPR020425	Nerve growth factor, beta subunit	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P04629	hereditary sensory and autonomic neuropathy type 4 familial medullary thyroid carcinoma malignant glioma neuroblastoma schizoaffective disorder Lewy body dementia neuralgia hereditary sensory and autonomic neuropathy schizophrenia Lung Injury mixed glioma bipolar disorder cancer medulloblastoma Charcot-Marie-Tooth disease hereditary sensory and autonomic neuropathy type 4 familial medullary thyroid carcinoma malignant glioma neuroblastoma schizoaffective disorder Lewy body dementia neuralgia hereditary sensory and autonomic neuropathy schizophrenia Lung Injury mixed glioma bipolar disorder cancer medulloblastoma Charcot-Marie-Tooth disease ovarian serous adenocarcinoma psoriasis hypothyroidism thyroid gland papillary carcinoma glioma non-small cell lung carcinoma hereditary sensory and autonomic neuropathy type 1 hereditary sensory and autonomic neuropathy type 5 Riley-Day syndrome intellectual disability schizophreniform disorder sensory peripheral neuropathy colorectal adenocarcinoma digestive system disease Hashimoto thyroiditis hereditary sensory and autonomic neuropathy type 2
C [auth E], D [auth F]	Pharos: P01138	hereditary sensory and autonomic neuropathy type 5 peripheral neuropathy neurodegenerative disease glomerulonephritis status epilepticus Nerve Degeneration corneal ulcer cystitis epilepsy with generalized tonic-clonic seizures interstitial nephritis peripheral nervous system disease Lewy body dementia middle cerebral artery infarction cocaine abuse nervous system disorder hereditary sensory and autonomic neuropathy type 5 peripheral neuropathy neurodegenerative disease glomerulonephritis status epilepticus Nerve Degeneration corneal ulcer cystitis epilepsy with generalized tonic-clonic seizures interstitial nephritis peripheral nervous system disease Lewy body dementia middle cerebral artery infarction cocaine abuse nervous system disorder overactive bladder Parkinson disease dissociative amnesia chronic kidney disease hereditary sensory and autonomic neuropathy hereditary sensory and autonomic neuropathy type 4 cocaine dependence heroin dependence visual epilepsy malignant mesothelioma hereditary sensory and autonomic neuropathy type 1 chronic renal failure syndrome sensory peripheral neuropathy toxic encephalopathy depressive disorder autosomal recessive juvenile Parkinson disease 2 phaeochromocytoma Charcot-Marie-Tooth disease Riley-Day syndrome heart disease hereditary sensory and autonomic neuropathy type 2 hydrolethalus syndrome alcohol withdrawal amnestic disorder cancer cystic fibrosis parkinsonian disorder intellectual disability cerebrovascular disorder