2IDH

Crystal Structure of human FE65 WW domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2idhb_	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2idhc_	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2idhd2	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2idhd3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2idhf_	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2idhh2	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2idhh3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2idha_	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2idhe_	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2idhg_	All beta proteins	WW domain-like	WW domain	WW domain	Amyloid beta A4 precursor protein-binding family B member 1, APBB1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	WW domain	8034231	3001621	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00397	e2idhB1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
C	PF00397	e2idhC1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
D	PF00397	e2idhD1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
F	PF00397	e2idhF1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
H	PF00397	e2idhH1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
A	PF00397	e2idhA1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
E	PF00397	e2idhE1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)
G	PF00397	e2idhG1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00397	WW domain (WW)	WW domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Amyloid beta A4 protein-binding family B member 1	protein binding binding histone binding amide binding amyloid-beta binding peptide binding protein-containing complex binding chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity proline-rich region binding protein binding binding histone binding amide binding amyloid-beta binding peptide binding protein-containing complex binding chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity proline-rich region binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process multicellular organismal process system process smooth muscle contraction muscle contraction muscle system process apoptotic process cell death programmed cell death cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process multicellular organismal process system process smooth muscle contraction muscle contraction muscle system process apoptotic process cell death programmed cell death regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process signaling signal transduction cell communication axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization positive regulation of neuron projection development positive regulation of cell projection organization regulation of cell projection organization regulation of plasma membrane bounded cell projection organization protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion organic substance transport regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition negative regulation of cell cycle process cell cycle G1/S phase transition negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of transcription by RNA polymerase II protein-DNA complex organization protein-containing complex organization chromatin organization	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cell periphery plasma membrane membrane cytoplasm growth cone axon distal axon neuron projection site of polarized growth synapse cell junction endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036020	WW domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR039576	Amyloid beta precursor protein binding family B member 1/2/3	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR006020	PTB/PI domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001202	WW domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: O00213	atypical teratoid rhabdoid tumor lung carcinoma medulloblastoma glioblastoma malignant glioma osteosarcoma large cell medulloblastoma malignant mesothelioma subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.