Annotations: 2IB1

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ib1a_	All alpha proteins	DEATH domain	DEATH domain	automated matches	automated matches	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DEATH domain DD	8073231	4000378	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8073232	3000069	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00531	e2ib1A1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: PF00531	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00531	Death domain (Death)	Death domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Death domain containing membrane protein NRADD	molecular transducer activity coreceptor activity signaling receptor activity transmembrane signaling receptor activity death receptor activity protein binding binding signaling receptor binding cytokine receptor binding neurotrophin receptor binding neurotrophin p75 receptor binding neurotrophin binding nerve growth factor binding growth factor binding	cellular process apoptotic process cell death programmed cell death cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling biological regulation Rho protein signal transduction intracellular signal transduction cell communication cellular process apoptotic process cell death programmed cell death cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling biological regulation Rho protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction	cell leading edge plasma membrane membrane neuron projection leading edge membrane cellular anatomical entity plasma membrane bounded cell projection neuron projection membrane cell periphery cell projection plasma membrane region cell projection membrane lamellipodium membrane-bounded organelle cell leading edge plasma membrane membrane neuron projection leading edge membrane cellular anatomical entity plasma membrane bounded cell projection neuron projection membrane cell periphery cell projection plasma membrane region cell projection membrane lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope organelle lumen organelle nuclear envelope lumen nuclear envelope cell body cell body membrane cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR000488	Death domain	Domain
A	IPR041448	Tumor necrosis factor receptor member 16, transmembrane domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.