2I91

60kDa Ro autoantigen in complex with a fragment of misfolded RNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d2i91a1	All alpha proteins	alpha-alpha superhelix	TROVE domain-like	TROVE domain-like	60-kda SS-aARo ribonucleoprotein	African clawed frog (Xenopus laevis ) [TaxId: 8355 ],	SCOPe (2.08)
E [auth A]	d2i91a2	Alpha and beta proteins (a/b)	vWA-like	vWA-like	RoRNP C-terminal domain-like	60-kda SS-A/Ro ribonucleoprotein, RoRNP	African clawed frog (Xenopus laevis ) [TaxId: 8355 ],	SCOPe (2.08)
F [auth B]	d2i91b1	All alpha proteins	alpha-alpha superhelix	TROVE domain-like	TROVE domain-like	60-kda SS-aARo ribonucleoprotein	African clawed frog (Xenopus laevis ) [TaxId: 8355 ],	SCOPe (2.08)
F [auth B]	d2i91b2	Alpha and beta proteins (a/b)	vWA-like	vWA-like	RoRNP C-terminal domain-like	60-kda SS-A/Ro ribonucleoprotein, RoRNP	African clawed frog (Xenopus laevis ) [TaxId: 8355 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2B Superfamily	vWA-like	8034956	3000832	SCOP2B (2022-06-29)
E [auth A]	SCOP2B Superfamily	TROVE domain-like	8034953	3001832	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	vWA-like	8034956	3000832	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	TROVE domain-like	8034953	3001832	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	PF05731	e2i91A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: TROVE domain-like (From Topology)	T: TROVE domain-like	F: PF05731	ECOD (1.6)
E [auth A]	F_UNCLASSIFIED	e2i91A2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth B]	PF05731	e2i91B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: TROVE domain-like (From Topology)	T: TROVE domain-like	F: PF05731	ECOD (1.6)
F [auth B]	F_UNCLASSIFIED	e2i91B2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	3.40.50.410	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	von Willebrand factor, type A domain	CATH (4.3.0)
F [auth B]	3.40.50.410	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	von Willebrand factor, type A domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth B]	PF05731	TROVE domain (TROVE)	TROVE domain	This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], C [auth E]	5'-R(GPCPCPUPAPCPCPC)-3'	-	-	-
B [auth D], D [auth F]	5'-R(CGPGPUPAPGPGPCPUPUPUPUPCPAP*A)-3'	-	-	-
E [auth A], F [auth B]	60 kDa SS-A/Ro ribonucleoprotein	RNA binding misfolded RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	cellular component organization cell projection organization cellular process cellular component organization or biogenesis	protein-containing complex ribonucleoprotein complex intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth B]	IPR008858	TROVE domain	Domain
E [auth A], F [auth B]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
E [auth A], F [auth B]	IPR040322	RNA-binding protein RO60	Family
E [auth A], F [auth B]	IPR037214	TROVE domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.