Annotations: 2I5T

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13772	e2i5tA1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF13772	ECOD (1.6)
B	PF13772	e2i5tB1	A: a+b two layers	X: BtrG-like (Pfam 03674) (From Topology)	H: BtrG-like (Pfam 03674) (From Topology)	T: BtrG-like (Pfam 03674)	F: PF13772	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.490.10	Alpha Beta	Roll	Hypothetical upf0131 protein ytfp	Gamma-glutamyl cyclotransferase-like	CATH (4.3.0)
B	3.10.490.10	Alpha Beta	Roll	Hypothetical upf0131 protein ytfp	Gamma-glutamyl cyclotransferase-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13772	AIG2-like family (AIG2_2)	AIG2-like family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein C7orf24	amidine-lyase activity gamma-glutamylcyclotransferase activity lyase activity catalytic activity carbon-nitrogen lyase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling apoptotic mitochondrial changes biological regulation cell death cell communication cellular component organization apoptotic signaling pathway release of cytochrome c from mitochondria organelle organization cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling apoptotic mitochondrial changes biological regulation cell death cell communication cellular component organization apoptotic signaling pathway release of cytochrome c from mitochondria organelle organization cellular process apoptotic process cellular component organization or biogenesis signal transduction programmed cell death mitochondrion organization	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036568	Gamma-glutamyl cyclotransferase-like superfamily	Homologous Superfamily
A, B	IPR013024	Gamma-glutamyl cyclotransferase-like	Domain
A, B	IPR017939	Gamma-glutamylcyclotransferase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O75223	astrocytic tumor ductal breast carcinoma in situ lung adenocarcinoma nasopharyngeal carcinoma Pick disease subependymal giant cell astrocytoma breast cancer IgA glomerulonephritis lung cancer non-small cell lung carcinoma plasma cell myeloma breast carcinoma invasive ductal breast carcinoma lymphoplasmacytic lymphoma ovarian cancer astrocytic tumor ductal breast carcinoma in situ lung adenocarcinoma nasopharyngeal carcinoma Pick disease subependymal giant cell astrocytoma breast cancer IgA glomerulonephritis lung cancer non-small cell lung carcinoma plasma cell myeloma breast carcinoma invasive ductal breast carcinoma lymphoplasmacytic lymphoma ovarian cancer psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.