Annotations: 2I4Q

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2i4qa1	All beta proteins	Acid proteases	Acid proteases	Pepsin-like	Chymosin (synonym: renin)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2i4qa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2i4qb1	All beta proteins	Acid proteases	Acid proteases	Pepsin-like	Chymosin (synonym: renin)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2i4qb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acid proteases	8042494	3001059	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acid proteases	8042494	3001059	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Asp_C	e2i4qA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: Asp_C	ECOD (1.6)
A	Asp_N	e2i4qA2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: Asp_N	ECOD (1.6)
B	Asp_C	e2i4qB3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: Asp_C	ECOD (1.6)
B	Asp_N	e2i4qB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: Asp_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)
B	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00026	Eukaryotic aspartyl protease (Asp)	Eukaryotic aspartyl protease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Renin	protein binding binding signaling receptor binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity aspartic-type peptidase activity aspartic-type endopeptidase activity endopeptidase activity insulin-like growth factor receptor binding	regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process cellular biosynthetic process signaling receptor ligand precursor processing protein maturation organic substance metabolic process circulatory system process proteolysis organic substance biosynthetic process amide metabolic process regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process cellular biosynthetic process signaling receptor ligand precursor processing protein maturation organic substance metabolic process circulatory system process proteolysis organic substance biosynthetic process amide metabolic process protein metabolic process regulation of biological quality blood circulation organonitrogen compound metabolic process regulation of blood pressure regulation of hormone levels cellular metabolic process biological regulation regulation of systemic arterial blood pressure by circulatory renin-angiotensin primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process regulation of systemic arterial blood pressure endocrine process biosynthetic process regulation of angiotensin levels in blood protein processing metabolic process cellular process macromolecule metabolic process angiotensin maturation developmental process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development amyloid-beta metabolic process juxtaglomerular apparatus development kidney development renal system development cellular response to stimulus regulation of biological process response to organic substance regulation of cellular process response to stimulus signaling response to endogenous stimulus hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical signal transduction cellular response to organic substance cellular response to hormone stimulus mesonephros development regulation of signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication regulation of localization regulation of blood volume by renin-angiotensin regulation of aldosterone secretion regulation of system process localization regulation of steroid hormone secretion aldosterone secretion mineralocorticoid secretion organic substance transport lipid transport regulation of corticosteroid hormone secretion establishment of localization regulation of secretion endocrine hormone secretion lipid export from cell renin-angiotensin regulation of aldosterone production regulation of mineralocorticoid secretion regulation of endocrine process corticosteroid hormone secretion regulation of hormone secretion transport steroid hormone secretion regulation of lipid transport organic hydroxy compound transport hormone secretion secretion by cell regulation of secretion by cell signal release regulation of multicellular organismal process renal system process involved in regulation of systemic arterial blood pressure renal system process secretion regulation of transport lipid localization export from cell cell-cell signaling regulation of lipid localization macromolecule localization hormone transport behavior drinking behavior feeding behavior cellular developmental process anatomical structure maturation cell differentiation cell development cell maturation developmental maturation response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to cGMP response to purine-containing compound response to organic cyclic compound response to immobilization stress response to stress cellular response to xenobiotic stimulus response to xenobiotic stimulus response to cAMP biological process involved in interspecies interaction between organisms response to lipid response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin	apical part of cell cellular anatomical entity cell periphery plasma membrane membrane extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001461	Aspartic peptidase A1 family	Family
A, B	IPR033121	Peptidase family A1 domain	Domain
A, B	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A, B	IPR001969	Aspartic peptidase, active site	Active Site
A, B	IPR034135	Renin-like domain	Domain
A, B	IPR012848	Aspartic peptidase, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P00797	psoriasis hypertensive disorder nephrosis Albuminuria kidney disease Liddle syndrome familial juvenile hyperuricemic nephropathy type 2 Bartter syndrome renal tubular dysgenesis of genetic origin substance withdrawal syndrome proteinuria congestive heart failure malignant hypertension myocardial infarction osteoporosis psoriasis hypertensive disorder nephrosis Albuminuria kidney disease Liddle syndrome familial juvenile hyperuricemic nephropathy type 2 Bartter syndrome renal tubular dysgenesis of genetic origin substance withdrawal syndrome proteinuria congestive heart failure malignant hypertension myocardial infarction osteoporosis anemia cirrhosis of liver coronary artery disease fetal growth restriction adenoma potassium deficiency disease heart failure hyperaldosteronism atherosclerosis type 2 diabetes mellitus bipolar disorder cerebrovascular disorder inherited lipid metabolism disorder congenital anomaly of kidney and urinary tract COVID-19 obesity disorder adult acute respiratory distress syndrome pustulosis palmaris et plantaris hyperglycemia thrombotic disease hypotensive disorder depressive disorder heart disease renal tubular dysgenesis transitional cell carcinoma inborn carbohydrate metabolic disorder ischemic disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.