2I44

Crystal structure of serine-threonine phosphatase 2C from Toxoplasma gondii

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PP2C-like	8091315	4007727	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PP2C-like	8091316	3000909	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	PP2C-like	8091316	3000909	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PP2C-like	8091316	3000909	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PP2C	e2i44A1	A: a+b four layers	X: Ntn/PP2C	H: Protein serine/threonine phosphatase 2C, catalytic domain (From Topology)	T: Protein serine/threonine phosphatase 2C, catalytic domain	F: PP2C	ECOD (1.6)
B	PP2C	e2i44B1	A: a+b four layers	X: Ntn/PP2C	H: Protein serine/threonine phosphatase 2C, catalytic domain (From Topology)	T: Protein serine/threonine phosphatase 2C, catalytic domain	F: PP2C	ECOD (1.6)
C	PP2C	e2i44C1	A: a+b four layers	X: Ntn/PP2C	H: Protein serine/threonine phosphatase 2C, catalytic domain (From Topology)	T: Protein serine/threonine phosphatase 2C, catalytic domain	F: PP2C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.40.10	Alpha Beta	4-Layer Sandwich	Phosphatase 2c	domain 1	CATH (4.3.0)
B	3.60.40.10	Alpha Beta	4-Layer Sandwich	Phosphatase 2c	domain 1	CATH (4.3.0)
C	3.60.40.10	Alpha Beta	4-Layer Sandwich	Phosphatase 2c	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00481	Protein phosphatase 2C (PP2C)	Protein phosphatase 2C	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Serine-threonine phosphatase 2C	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR036457	PPM-type phosphatase-like domain superfamily	Homologous Superfamily
A, B, C	IPR015655	Protein phosphatase 2C	Family
A, B, C	IPR001932	PPM-type phosphatase-like domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.