This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [1]. The structure of one member-sequence represents a variation of the RecA fold, and implies that ...
This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [1]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [2]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [3].