2HYT

CRYSTAL STRUCTURE OF A TETR-FAMILY TRANSCRIPTIONAL REGULATOR (ECA1819) FROM PECTOBACTERIUM ATROSEPTICUM AT 1.64 A RESOLUTION

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Tetracyclin repressor-like	8085364	4000333	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Homeodomain-like	8086620	3000001	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	TetR C-terminal domain-like	8088258	3000086	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00440	e2hytA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
A	PF21351	e2hytA2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21351	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.357.10	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21351	Tetracyclin repressor-like, C-terminal domain (TetR_C_41)	Tetracyclin repressor-like, C-terminal domain	This domain is found at the C-terminal end of transcriptional regulators of the TetR family, including Swiss:O53623 from Mycobacterium tuberculosis and Swiss:Q1D4I5 from Myxococcus xanthus. This is the all-helical ligand-binding domain, which interac ...	This domain is found at the C-terminal end of transcriptional regulators of the TetR family, including Swiss:O53623 from Mycobacterium tuberculosis and Swiss:Q1D4I5 from Myxococcus xanthus. This is the all-helical ligand-binding domain, which interacts with the respective effector molecule and transmits the signal to the DNA binding domain (Pfam:PF00440).	Domain
A	PF00440	Bacterial regulatory proteins, tetR family (TetR_N)	Bacterial regulatory proteins, tetR family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	TetR-family transcriptional regulator	DNA binding binding organic cyclic compound binding nucleic acid binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023772	DNA-binding HTH domain, TetR-type, conserved site	Conserved Site
A	IPR049484	Transcriptional regulator Rv0078-like, C-terminal domain	Domain
A	IPR001647	DNA-binding HTH domain, TetR-type	Domain
A	IPR036271	Tetracyclin repressor-like, C-terminal domain superfamily	Homologous Superfamily
A	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.