2HV2

Crystal Structure of Conserved Protein of Unknown Function from Enterococcus faecalis V583 at 2.4 A Resolution, Probable N-Acyltransferase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2hv2a1	Alpha and beta proteins (a+b)	SCP-like	SCP-like	EF1021 C-terminal domain-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
A	d2hv2a2	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	EF1021-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
B	d2hv2b1	Alpha and beta proteins (a+b)	SCP-like	SCP-like	EF1021 C-terminal domain-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
B	d2hv2b2	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	EF1021-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
C	d2hv2c1	Alpha and beta proteins (a+b)	SCP-like	SCP-like	EF1021 C-terminal domain-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
C	d2hv2c2	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	EF1021-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
D	d2hv2d1	Alpha and beta proteins (a+b)	SCP-like	SCP-like	EF1021 C-terminal domain-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
D	d2hv2d2	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	EF1021-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
E	d2hv2e1	Alpha and beta proteins (a+b)	SCP-like	SCP-like	EF1021 C-terminal domain-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
E	d2hv2e2	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	EF1021-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
F	d2hv2f1	Alpha and beta proteins (a+b)	SCP-like	SCP-like	EF1021 C-terminal domain-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)
F	d2hv2f2	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	EF1021-like	Hypothetical protein EF1021	(Enterococcus faecalis ) [TaxId: 1351 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	EF1021 C-terminal domain-like	8021901	4002273	SCOP2 (2022-06-29)
A	SCOP2 Family	EF1021-like	8021905	4002291	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SCP2-like	8034281	3000148	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Acyl-CoA N-acyltransferases (Nat)	8034285	3000403	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	SCP2-like	8034281	3000148	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8034285	3000403	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SCP2-like	8034281	3000148	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8034285	3000403	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8034285	3000403	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SCP2-like	8034281	3000148	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	SCP2-like	8034281	3000148	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8034285	3000403	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8034285	3000403	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	SCP2-like	8034281	3000148	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SCP2_2_C	e2hv2A1	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
A	Acetyltransf_9	e2hv2A2	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_9	ECOD (1.6)
B	SCP2_2_C	e2hv2B5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
B	SCP2_2_N	e2hv2B1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
B	Acetyltransf_9	e2hv2B3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_9	ECOD (1.6)
C	SCP2_2_C	e2hv2C5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
C	SCP2_2_N	e2hv2C4	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
C	Acetyltransf_9	e2hv2C3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_9	ECOD (1.6)
D	SCP2_2_C	e2hv2D5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
D	SCP2_2_N	e2hv2D4	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
D	Acetyltransf_9	e2hv2D3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_9	ECOD (1.6)
E	SCP2_2_C	e2hv2E5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
E	SCP2_2_N	e2hv2E4	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
E	Acetyltransf_9	e2hv2E3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_9	ECOD (1.6)
F	SCP2_2_C	e2hv2F5	A: a+b two layers	X: Sterol carrier protein-like	H: Sterol carrier protein, SCP-related (From Topology)	T: Sterol carrier protein, SCP-related	F: SCP2_2_C	ECOD (1.6)
F	SCP2_2_N	e2hv2F4	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: SCP2_2_N	ECOD (1.6)
F	Acetyltransf_9	e2hv2F3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_9	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
A	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
B	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
C	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
C	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
D	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
D	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
E	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
E	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)
F	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
F	3.30.1050.10	Alpha Beta	2-Layer Sandwich	Nonspecific Lipid-transfer Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF13527	Acetyltransferase (GNAT) domain (Acetyltransf_9)	Acetyltransferase (GNAT) domain	This domain catalyses N-acetyltransferase reactions.	Domain
A, B, C, D, E A, B, C, D, E, F	PF13530	Sterol carrier protein domain (SCP2_2)	Sterol carrier protein domain	-	Domain
A, B, C, D, E A, B, C, D, E, F	PF17668	Acetyltransferase (GNAT) domain (Acetyltransf_17)	Acetyltransferase (GNAT) domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Hypothetical protein	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR025559	Enhanced intracellular survival protein domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036527	SCP2 sterol-binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR041380	Eis-like, acetyltransferase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR000182	GNAT domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.