Annotations: 2HU7

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2hu7a1	All beta proteins	7-bladed beta-propeller	Peptidase/esterase 'gauge' domain	Acylamino-acid-releasing enzyme, N-terminal donain	Acylamino-acid-releasing enzyme, N-terminal donain	(Aeropyrum pernix ) [TaxId: 56636 ],	SCOPe (2.08)
A	d2hu7a2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acylamino-acid-releasing enzyme, C-terminal donain	Acylamino-acid-releasing enzyme, C-terminal donain	(Aeropyrum pernix ) [TaxId: 56636 ],	SCOPe (2.08)
B	d2hu7b1	All beta proteins	7-bladed beta-propeller	Peptidase/esterase 'gauge' domain	Acylamino-acid-releasing enzyme, N-terminal donain	Acylamino-acid-releasing enzyme, N-terminal donain	(Aeropyrum pernix ) [TaxId: 56636 ],	SCOPe (2.08)
B	d2hu7b2	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acylamino-acid-releasing enzyme, C-terminal donain	Acylamino-acid-releasing enzyme, C-terminal donain	(Aeropyrum pernix ) [TaxId: 56636 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Acylamino-acid-releasing enzyme C-terminal domain-like	8030059	4003568	SCOP2 (2022-06-29)
A	SCOP2 Family	Acylamino-acid-releasing enzyme N-terminal donain	8030058	4003223	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha/beta-Hydrolases	8042438	3000102	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Peptidase/esterase 'gauge' domain	8042437	3001719	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8042438	3000102	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Peptidase/esterase 'gauge' domain	8042437	3001719	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22173	e2hu7A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF22173	ECOD (1.6)
A	PF00326	e2hu7A2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF00326	ECOD (1.6)
B	PF22173	e2hu7B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF22173	ECOD (1.6)
B	PF00326	e2hu7B2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PF00326	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.150	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	2.130.10.150	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00326	Prolyl oligopeptidase family (Peptidase_S9)	Prolyl oligopeptidase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Acylamino-acid-releasing enzyme	peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity omega peptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001375	Peptidase S9, prolyl oligopeptidase, catalytic domain	Domain
A, B	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.