2HQT

Crystal structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA aminoacylation and nuclear export cofactor Arc1p reveal a novel function for an old fold

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2hqta1	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d2hqtb_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d2hqtc_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d2hqtd_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d2hqte_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F	d2hqtf2	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F	d2hqtf3	Artifacts	Tags	Tags	Tags	N-terminal Tags	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
G	d2hqtg_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
H	d2hqth_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
I	d2hqti_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
J	d2hqtj2	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
J	d2hqtj3	Artifacts	Tags	Tags	Tags	N-terminal Tags	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
K	d2hqtk_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
L	d2hqtl_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
M	d2hqtm_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
N	d2hqtn_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
O	d2hqto_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
P	d2hqtp_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
Q	d2hqtq_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
R	d2hqtr_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
S	d2hqts_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
T	d2hqtt_	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Arc1p N-terminal domain-like	GU4 nucleic-binding protein 1, Arc1p	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	GST C-terminal domain-like	8034258	3000305	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GST_C_Arc1p_N_like	e2hqtA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
B	GST_C_Arc1p_N_like	e2hqtB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
C	GST_C_Arc1p_N_like	e2hqtC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
D	GST_C_Arc1p_N_like	e2hqtD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
E	GST_C_Arc1p_N_like	e2hqtE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
F	GST_C_Arc1p_N_like	e2hqtF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
G	GST_C_Arc1p_N_like	e2hqtG1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
H	GST_C_Arc1p_N_like	e2hqtH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
I	GST_C_Arc1p_N_like	e2hqtI1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
J	GST_C_Arc1p_N_like	e2hqtJ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
K	GST_C_Arc1p_N_like	e2hqtK1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
L	GST_C_Arc1p_N_like	e2hqtL1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
M	GST_C_Arc1p_N_like	e2hqtM1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
N	GST_C_Arc1p_N_like	e2hqtN1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
O	GST_C_Arc1p_N_like	e2hqtO1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
P	GST_C_Arc1p_N_like	e2hqtP1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
Q	GST_C_Arc1p_N_like	e2hqtQ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
R	GST_C_Arc1p_N_like	e2hqtR1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
S	GST_C_Arc1p_N_like	e2hqtS1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)
T	GST_C_Arc1p_N_like	e2hqtT1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_Arc1p_N_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
B	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
C	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
D	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
E	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
F	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
G	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
H	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
I	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
J	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
K	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
L	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
M	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
N	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
O	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
P	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
Q	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
R	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
S	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)
T	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	GU4 nucleic-binding protein 1	phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity phosphatidylinositol-3-phosphate binding RNA binding organic cyclic compound binding tRNA binding nucleic acid binding	amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process glutamyl-tRNA aminoacylation organonitrogen compound metabolic process cellular metabolic process primary metabolic process amino acid activation tRNA aminoacylation cellular biosynthetic process organonitrogen compound biosynthetic process RNA metabolic process amino acid metabolic process nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process protein metabolic process glutamyl-tRNA aminoacylation organonitrogen compound metabolic process cellular metabolic process primary metabolic process translation gene expression tRNA aminoacylation for protein translation macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process metabolic process cellular process macromolecule metabolic process methionyl-tRNA aminoacylation	intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule protein-containing complex methionyl glutamyl tRNA synthetase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR002547	tRNA-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR036282	Glutathione S-transferase, C-terminal domain superfamily	Homologous Superfamily