2HLO

Crystal Structure of Fragment D-dimer from Human Fibrin Complexed with Gly-hydroxyPro-Arg-Pro-amide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2hloa1	Coiled coil proteins	Parallel coiled-coil	Fibrinogen coiled-coil and central regions	Fibrinogen coiled-coil and central regions	Fibrinogen alpha chain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Fibrinogen coiled-coil and central regions	8043725	3001470	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Fibrinogen coiled-coil and central regions	8043725	3001470	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibrinogen C-terminal domain-like	8038835	3001395	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibrinogen coiled-coil and central regions	8038837	3001470	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Fibrinogen C-terminal domain-like	8038835	3001395	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Fibrinogen coiled-coil and central regions	8038837	3001470	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibrinogen C-terminal domain-like	8037157	3001395	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibrinogen coiled-coil and central regions	8039526	3001470	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Fibrinogen C-terminal domain-like	8037157	3001395	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00147,PF08702	e2hloB1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: PF00147,PF08702	ECOD (1.6)
E	PF00147,PF08702	e2hloE1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: PF00147,PF08702	ECOD (1.6)
C	PF00147,PF08702	e2hloC1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: PF00147,PF08702	ECOD (1.6)
F	PF00147,PF08702	e2hloF1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: PF00147,PF08702	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.50	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D	1.20.5.50	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	3.90.215.10	Alpha Beta	Alpha-Beta Complex	Gamma Fibrinogen	Chain A, domain 1	CATH (4.3.0)
B	4.10.530.10	Few Secondary Structures	Irregular	Gamma-fibrinogen Carboxyl Terminal Fragment	domain 2	CATH (4.3.0)
E	3.90.215.10	Alpha Beta	Alpha-Beta Complex	Gamma Fibrinogen	Chain A, domain 1	CATH (4.3.0)
E	4.10.530.10	Few Secondary Structures	Irregular	Gamma-fibrinogen Carboxyl Terminal Fragment	domain 2	CATH (4.3.0)
C	3.90.215.10	Alpha Beta	Alpha-Beta Complex	Gamma Fibrinogen	Chain A, domain 1	CATH (4.3.0)
C	4.10.530.10	Few Secondary Structures	Irregular	Gamma-fibrinogen Carboxyl Terminal Fragment	domain 2	CATH (4.3.0)
F	3.90.215.10	Alpha Beta	Alpha-Beta Complex	Gamma Fibrinogen	Chain A, domain 1	CATH (4.3.0)
F	4.10.530.10	Few Secondary Structures	Irregular	Gamma-fibrinogen Carboxyl Terminal Fragment	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF08702	Fibrinogen alpha/beta chain family (Fib_alpha)	Fibrinogen alpha/beta chain family	-	Coiled-coil
B, E	PF00147	Fibrinogen beta and gamma chains, C-terminal globular domain (Fibrinogen_C)	Fibrinogen beta and gamma chains, C-terminal globular domain	-	Domain
B, E	PF08702	Fibrinogen alpha/beta chain family (Fib_alpha)	Fibrinogen alpha/beta chain family	-	Coiled-coil
C, F	PF00147	Fibrinogen beta and gamma chains, C-terminal globular domain (Fibrinogen_C)	Fibrinogen beta and gamma chains, C-terminal globular domain	-	Domain
C, F	PF08702	Fibrinogen alpha/beta chain family (Fib_alpha)	Fibrinogen alpha/beta chain family	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Fibrinogen alpha chain	protein binding binding signaling receptor binding structural molecule activity extracellular matrix structural constituent cation binding ion binding metal ion binding small molecule binding	cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein polymerization response to stimulus immune response immune system process cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein polymerization response to stimulus immune response immune system process adaptive immune response cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling regulation of tube diameter multicellular organismal process system process regulation of tube size regulation of system process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size response to metal ion response to chemical response to calcium ion response to inorganic substance regulation of body fluid levels blood coagulation, common pathway cellular biosynthetic process protein maturation organic substance metabolic process response to stress blood coagulation, fibrin clot formation organic substance biosynthetic process coagulation protein metabolic process response to wounding wound healing protein activation cascade organonitrogen compound metabolic process cellular metabolic process hemostasis primary metabolic process gene expression macromolecule biosynthetic process blood coagulation biosynthetic process metabolic process macromolecule metabolic process extrinsic apoptotic signaling pathway via death domain receptors negative regulation of signaling negative regulation of biological process regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of localization transport positive regulation of secretion by cell positive regulation of exocytosis vesicle-mediated transport localization regulation of secretion by cell secretion by cell positive regulation of secretion regulation of transport secretion export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion positive regulation of transport exocytosis regulation of exocytosis regulation of response to external stimulus regulation of response to wounding regulation of coagulation regulation of response to stress regulation of hemostasis negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation response to external stimulus negative regulation of response to wounding negative regulation of hemostasis fibrinolysis negative regulation of coagulation negative regulation of response to external stimulus regulation of wound healing negative regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus homotypic cell-cell adhesion cell activation platelet aggregation cell-cell adhesion platelet activation zymogen activation proteolysis protein processing plasminogen activation positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization positive regulation of establishment of protein localization protein localization to extracellular region positive regulation of protein transport cellular macromolecule localization organic substance transport regulation of establishment of protein localization establishment of protein localization to extracellular region regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization positive regulation of cell-cell adhesion heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion humoral immune response antibacterial humoral response antimicrobial humoral response defense response to bacterium induction of bacterial agglutination response to bacterium negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process epithelial cell apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process regulation of hormone secretion regulation of peptide secretion hormone secretion peptide secretion positive regulation of hormone secretion amide transport signal release regulation of peptide hormone secretion positive regulation of peptide secretion regulation of hormone levels positive regulation of peptide hormone secretion regulation of peptide transport cell-cell signaling peptide transport peptide hormone secretion hormone transport	protein-containing complex extracellular region extracellular space cellular anatomical entity fibrinogen complex cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex extracellular region extracellular space cellular anatomical entity fibrinogen complex cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix blood microparticle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule vesicle lumen cytoplasmic vesicle lumen secretory granule lumen platelet alpha granule lumen
B, E	Fibrinogen beta chain	protein binding binding signaling receptor binding protein-folding chaperone binding structural molecule activity extracellular matrix structural constituent	cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein polymerization response to stimulus immune response immune system process cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein polymerization response to stimulus immune response immune system process adaptive immune response cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling regulation of tube diameter multicellular organismal process system process regulation of tube size regulation of system process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size response to metal ion response to chemical response to calcium ion response to inorganic substance extrinsic apoptotic signaling pathway via death domain receptors negative regulation of signaling negative regulation of biological process regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of localization transport positive regulation of secretion by cell positive regulation of exocytosis vesicle-mediated transport localization regulation of secretion by cell secretion by cell positive regulation of secretion regulation of transport secretion export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion positive regulation of transport exocytosis regulation of exocytosis regulation of body fluid levels regulation of response to external stimulus regulation of response to wounding regulation of coagulation response to stress regulation of response to stress coagulation response to wounding regulation of hemostasis wound healing negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation hemostasis response to external stimulus negative regulation of response to wounding blood coagulation negative regulation of hemostasis fibrinolysis negative regulation of coagulation negative regulation of response to external stimulus regulation of wound healing negative regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus cellular biosynthetic process protein maturation organic substance metabolic process blood coagulation, fibrin clot formation organic substance biosynthetic process protein metabolic process protein activation cascade organonitrogen compound metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process homotypic cell-cell adhesion cell activation platelet aggregation cell-cell adhesion platelet activation zymogen activation proteolysis protein processing plasminogen activation positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization positive regulation of establishment of protein localization protein localization to extracellular region positive regulation of protein transport cellular macromolecule localization organic substance transport regulation of establishment of protein localization establishment of protein localization to extracellular region regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization response to organic substance response to endogenous stimulus cellular response to leptin stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to leptin cellular response to organic substance cellular response to hormone stimulus positive regulation of cell-cell adhesion heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion humoral immune response antibacterial humoral response antimicrobial humoral response defense response to bacterium induction of bacterial agglutination response to bacterium negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process epithelial cell apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process regulation of hormone secretion regulation of peptide secretion hormone secretion peptide secretion positive regulation of hormone secretion amide transport signal release regulation of peptide hormone secretion positive regulation of peptide secretion regulation of hormone levels positive regulation of peptide hormone secretion regulation of peptide transport cell-cell signaling peptide transport peptide hormone secretion hormone transport response to cytokine cellular response to interleukin-1 cellular response to cytokine stimulus response to interleukin-1	protein-containing complex extracellular region extracellular space cellular anatomical entity fibrinogen complex cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cell cortex intracellular anatomical structure cytoplasm protein-containing complex extracellular region extracellular space cellular anatomical entity fibrinogen complex cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cell cortex intracellular anatomical structure cytoplasm extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix blood microparticle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule synapse cell junction vesicle lumen membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular organelle lumen organelle lumen platelet alpha granule lumen endoplasmic reticulum
C, F	Isoform Gamma-A of Fibrinogen gamma chain	protein binding binding signaling receptor binding cell adhesion molecule binding structural molecule activity extracellular matrix structural constituent cation binding ion binding metal ion binding small molecule binding identical protein binding	cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis developmental process cellular developmental process anatomical structure maturation platelet maturation cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis developmental process cellular developmental process anatomical structure maturation platelet maturation cell differentiation anatomical structure development cell development cell maturation developmental maturation protein polymerization cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling regulation of tube diameter multicellular organismal process system process regulation of tube size regulation of system process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size response to metal ion response to chemical response to calcium ion response to inorganic substance extrinsic apoptotic signaling pathway via death domain receptors negative regulation of signaling negative regulation of biological process regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of localization transport positive regulation of secretion by cell positive regulation of exocytosis vesicle-mediated transport localization regulation of secretion by cell secretion by cell positive regulation of secretion regulation of transport secretion export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion positive regulation of transport exocytosis regulation of exocytosis regulation of body fluid levels regulation of response to external stimulus regulation of response to wounding regulation of coagulation response to stress regulation of response to stress coagulation response to wounding regulation of hemostasis wound healing negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation hemostasis response to external stimulus negative regulation of response to wounding blood coagulation negative regulation of hemostasis fibrinolysis negative regulation of coagulation negative regulation of response to external stimulus regulation of wound healing negative regulation of multicellular organismal process cellular biosynthetic process protein maturation organic substance metabolic process blood coagulation, fibrin clot formation organic substance biosynthetic process protein metabolic process protein activation cascade organonitrogen compound metabolic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process biosynthetic process metabolic process macromolecule metabolic process homotypic cell-cell adhesion cell activation platelet aggregation cell-cell adhesion platelet activation zymogen activation proteolysis protein processing plasminogen activation positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization positive regulation of establishment of protein localization protein localization to extracellular region positive regulation of protein transport cellular macromolecule localization organic substance transport regulation of establishment of protein localization establishment of protein localization to extracellular region regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization response to organic substance response to interleukin-6 cellular response to interleukin-6 response to cytokine cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance positive regulation of cell-cell adhesion heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process epithelial cell apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process regulation of hormone secretion regulation of peptide secretion hormone secretion peptide secretion positive regulation of hormone secretion amide transport signal release regulation of peptide hormone secretion positive regulation of peptide secretion regulation of hormone levels positive regulation of peptide hormone secretion regulation of peptide transport cell-cell signaling peptide transport peptide hormone secretion hormone transport cellular response to interleukin-1 response to interleukin-1	protein-containing complex extracellular region extracellular space cellular anatomical entity fibrinogen complex cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex extracellular region extracellular space cellular anatomical entity fibrinogen complex cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix blood microparticle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule vesicle lumen cytoplasmic vesicle lumen secretory granule lumen platelet alpha granule lumen
G, H	GLY-HYP-ARG-PRO-AMIDE PEPTIDE LIGAND	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR037579	Fibrinogen	Family
A, D	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain	Domain
A, D	IPR020837	Fibrinogen, conserved site	Conserved Site
A, D	IPR021996	Fibrinogen alpha C domain	Domain
A, D	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily
A, D	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
A, D	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily
B, E	IPR037579	Fibrinogen	Family
B, E	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain	Domain
B, E	IPR020837	Fibrinogen, conserved site	Conserved Site
B, E	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily
B, E	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
B, E	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily
C, F	IPR037579	Fibrinogen	Family
C, F	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain	Domain
C, F	IPR020837	Fibrinogen, conserved site	Conserved Site
C, F	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily
C, F	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
C, F	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: P02671	congenital afibrinogenemia familial visceral amyloidosis thrombophilia pulmonary embolism familial dysfibrinogenemia kidney disease osteoporosis venous thromboembolism amyloidosis cholestasis Dysfibrinogenemia, Congenital hereditary amyloidosis acquired metabolic disease osteosarcoma periodic fever syndrome congenital afibrinogenemia familial visceral amyloidosis thrombophilia pulmonary embolism familial dysfibrinogenemia kidney disease osteoporosis venous thromboembolism amyloidosis cholestasis Dysfibrinogenemia, Congenital hereditary amyloidosis acquired metabolic disease osteosarcoma periodic fever syndrome thrombotic disease drug-induced hepatitis familial hypofibrinogenemia lung adenocarcinoma ovarian cancer cerebrovascular disorder lung cancer oral cavity neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia vascular disease drug-induced liver injury
B, E	Pharos: P02675	congenital afibrinogenemia Dysfibrinogenemia, Congenital osteoporosis familial dysfibrinogenemia Parkinson disease pancreatic ductal adenocarcinoma vascular disease familial hypofibrinogenemia lung adenocarcinoma
C, F	Pharos: P02679	congenital afibrinogenemia familial dysfibrinogenemia keloid Dysfibrinogenemia, Congenital vascular disease adenoma gastric cancer lung carcinoma pancreatic ductal adenocarcinoma cystic fibrosis familial hypofibrinogenemia gastric neoplasm sarcoidosis hereditary diffuse gastric adenocarcinoma lung cancer congenital afibrinogenemia familial dysfibrinogenemia keloid Dysfibrinogenemia, Congenital vascular disease adenoma gastric cancer lung carcinoma pancreatic ductal adenocarcinoma cystic fibrosis familial hypofibrinogenemia gastric neoplasm sarcoidosis hereditary diffuse gastric adenocarcinoma lung cancer non-small cell lung carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
G, H	HYP	Parent Component: PRO RESID: AA0030 PSI-MOD : 4-hydroxy-L-proline MOD:00039
G, H	NH2	RESID: AA0030 , AA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100 PSI-MOD : 4-hydroxy-L-proline MOD:00039 , L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.