2HEK

Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d2hekb_	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	HD domain	automated matches	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)
A	d2heka1	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	HD domain	Hypothetical protein aq_1910	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	HD-domain/PDEase-like	8042256	3000943	SCOP2B (2022-06-29)
A	SCOP2 Family	HD domain-like	8029877	4000705	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HD-domain/PDEase-like	8042256	3000943	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF01966,PF19276	e2hekB1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)
A	PF01966,PF19276	e2hekA1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PF01966,PF19276	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
B	3.30.70.1370	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	HD domain like	CATH (4.3.0)
A	1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	CATH (4.3.0)
A	3.30.70.1370	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	HD domain like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF19276	HD associated region (HD_assoc_2)	HD associated region	-	Family
A, B	PF01966	HD domain (HD)	HD domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Hypothetical protein	phosphoric ester hydrolase activity triphosphoric monoester hydrolase activity dGTPase activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity	deoxyribonucleotide catabolic process catabolic process nucleoside triphosphate catabolic process purine nucleoside triphosphate catabolic process purine deoxyribonucleoside triphosphate metabolic process carbohydrate derivative metabolic process organophosphate catabolic process dGTP metabolic process nucleoside phosphate catabolic process deoxyribose phosphate catabolic process nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process deoxyribonucleotide metabolic process purine deoxyribonucleoside triphosphate catabolic process deoxyribonucleotide catabolic process catabolic process nucleoside triphosphate catabolic process purine nucleoside triphosphate catabolic process purine deoxyribonucleoside triphosphate metabolic process carbohydrate derivative metabolic process organophosphate catabolic process dGTP metabolic process nucleoside phosphate catabolic process deoxyribose phosphate catabolic process nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process deoxyribonucleotide metabolic process purine deoxyribonucleoside triphosphate catabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process nucleotide catabolic process deoxyribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process purine deoxyribonucleotide catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process primary metabolic process purine-containing compound catabolic process deoxyribonucleoside triphosphate catabolic process nucleotide metabolic process deoxyribose phosphate metabolic process organic cyclic compound catabolic process purine-containing compound metabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process organophosphate metabolic process purine deoxyribonucleotide metabolic process metabolic process cellular process nucleoside triphosphate metabolic process dGTP catabolic process organic substance catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003607	HD/PDEase domain	Domain
A, B	IPR045509	HD-associated domain	Domain
A, B	IPR006674	HD domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.