Annotations: 2H8R

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	Homeodomain-like	8077675	3000001	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Homeodomain-like	8077675	3000001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	Homeobox	e2h8rA2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Homeobox	ECOD (1.6)
C [auth A]	HNF-1_N_C	e2h8rA1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: HNF-1_N_C	ECOD (1.6)
D [auth B]	Homeobox	e2h8rB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Homeobox	ECOD (1.6)
D [auth B]	HNF-1_N_C	e2h8rB2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: HNF-1_N_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
C [auth A]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)
D [auth B]	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
D [auth B]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF04814	Hepatocyte nuclear factor 1 (HNF-1), N terminus (HNF-1_N)	Hepatocyte nuclear factor 1 (HNF-1), N terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	5'-D(CPTPTPGPGPTPTPAPAPTPAPAPTPTPCPAPCPCPAPG)-3'	-	-	-
C [auth A], D [auth B]	Hepatocyte nuclear factor 1-beta	transcription factor binding transcription coregulator binding protein binding binding DNA binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity identical protein binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor binding transcription coregulator binding protein binding binding DNA binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity identical protein binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein homodimerization activity protein dimerization activity	developmental process multicellular organismal process epithelium development cellular developmental process hepatoblast differentiation gland development animal organ development tissue development liver development epithelial cell differentiation multicellular organism development stem cell differentiation cell differentiation hepaticobiliary system development anatomical structure development developmental process multicellular organismal process epithelium development cellular developmental process hepatoblast differentiation gland development animal organ development tissue development liver development epithelial cell differentiation multicellular organism development stem cell differentiation cell differentiation hepaticobiliary system development anatomical structure development cellular process system development head development brain development nervous system development central nervous system development hindbrain development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis tube morphogenesis morphogenesis of a branching structure epithelial tube morphogenesis morphogenesis of a branching epithelium regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process negative regulation of mesenchymal cell apoptotic process regulation of somatic stem cell population maintenance negative regulation of biological process regulation of kidney development regulation of programmed cell death stem cell population maintenance negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis mesenchymal cell apoptotic process involved in nephron morphogenesis somatic stem cell population maintenance animal organ morphogenesis nephron development negative regulation of programmed cell death regulation of apoptotic process regulation of mesenchymal cell apoptotic process regulation of stem cell population maintenance cell death negative regulation of stem cell population maintenance negative regulation of apoptotic process involved in development negative regulation of apoptotic process regulation of apoptotic process involved in morphogenesis regulation of mesonephros development negative regulation of somatic stem cell population maintenance maintenance of cell number negative regulation of multicellular organismal process apoptotic process involved in morphogenesis mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis nephron morphogenesis regulation of developmental process regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis mesonephros morphogenesis mesonephric nephron development renal system development mesonephric nephron morphogenesis apoptotic process involved in development negative regulation of apoptotic process involved in morphogenesis negative regulation of kidney development negative regulation of cellular process regulation of multicellular organismal process negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis mesenchymal cell apoptotic process mesonephros development negative regulation of developmental process regulation of apoptotic process involved in development kidney morphogenesis negative regulation of mesonephros development mesenchymal stem cell maintenance involved in nephron morphogenesis regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis apoptotic process kidney development programmed cell death mesonephric epithelium development regulation of growth kidney epithelium development developmental growth nephron tubule morphogenesis branch elongation involved in ureteric bud branching regulation of branch elongation involved in ureteric bud branching branch elongation of an epithelium developmental growth involved in morphogenesis mesonephric tubule development renal tubule morphogenesis nephron epithelium morphogenesis ureteric bud elongation nephron tubule development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron epithelium development ureteric bud development axis elongation regulation of developmental growth growth mesonephric tubule morphogenesis embryonic epithelial tube formation nephric duct morphogenesis nephric duct formation tube formation embryo development epithelial tube formation nephron tubule formation mesonephric duct formation morphogenesis of embryonic epithelium mesonephric tubule formation embryonic morphogenesis mesonephric duct morphogenesis nephric duct development anatomical structure formation involved in morphogenesis mesonephric duct development pronephros morphogenesis regulation of kidney size pronephros development regulation of biological quality regulation of pronephros size regulation of anatomical structure size chordate embryonic development inner cell mass cell differentiation in utero embryonic development blastocyst formation embryo development ending in birth or egg hatching blastocyst development regulation of mesenchymal cell apoptotic process involved in metanephros development metanephros development mesenchymal cell apoptotic process involved in metanephros development negative regulation of mesenchymal cell apoptotic process involved in metanephros development negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process negative regulation of biosynthetic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction pronephric nephron development pronephric nephron tubule development protein localization establishment of protein localization cellular localization nitrogen compound transport transport hormone secretion protein localization to extracellular region peptide secretion localization secretion by cell amide transport signal release cellular macromolecule localization secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region cell-cell signaling export from cell protein secretion establishment of localization peptide transport protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion response to hexose response to organic substance response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound pancreas development endocrine system development endocrine pancreas development regulation of DNA-templated transcription initiation transcription initiation at RNA polymerase II promoter positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of transcription initiation by RNA polymerase II DNA-templated transcription initiation positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II regulation of signaling regulation of Wnt signaling pathway regulation of signal transduction regulation of response to stimulus regulation of cell communication Wnt signaling pathway cell population proliferation epithelial cell proliferation embryonic organ morphogenesis digestive system development embryonic digestive tract morphogenesis digestive tract development digestive tract morphogenesis embryonic organ development embryonic digestive tract development formation of primary germ layer endodermal cell fate specification cell fate specification gastrulation cell fate commitment involved in formation of primary germ layer endoderm development endoderm formation cell fate commitment endodermal cell fate commitment endodermal cell differentiation genitalia development reproductive system development reproductive process sex differentiation developmental process involved in reproduction reproductive structure development anterior/posterior pattern specification pattern specification process regionalization	protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular membrane-bounded organelle nucleus protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B [auth F]	5'-D(GPCPTPGPGPTPGPAPAPTPTPAPTPTPAPAPCPCPAPA)-3'	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR044869	HNF-1, POU-specific (POUs) atypical domain	Domain
C [auth A], D [auth B]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR023219	Hepatocyte nuclear factor 1, N-terminal domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR044866	HNF-1, dimerization domain	Domain
C [auth A], D [auth B]	IPR006899	Hepatocyte nuclear factor 1, N-terminal	Domain
C [auth A], D [auth B]	IPR001356	Homeobox domain	Domain
C [auth A], D [auth B]	IPR006897	Hepatocyte nuclear factor 1, beta isoform, C-terminal	Domain
C [auth A], D [auth B]	IPR039066	Hepatocyte nuclear factor 1	Family
C [auth A], D [auth B]	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A], D [auth B]	Pharos: P35680	prostate cancer chromosome 17q12 deletion syndrome renal cysts and diabetes syndrome chromophobe renal cell carcinoma renal cell carcinoma type 2 diabetes mellitus maturity-onset diabetes of the young lung carcinoma congenital anomaly of kidney and urinary tract sarcomatoid renal cell carcinoma collecting duct carcinoma familial prostate carcinoma papillary renal cell carcinoma renal hypomagnesemia 2 testicular germ cell tumor prostate cancer chromosome 17q12 deletion syndrome renal cysts and diabetes syndrome chromophobe renal cell carcinoma renal cell carcinoma type 2 diabetes mellitus maturity-onset diabetes of the young lung carcinoma congenital anomaly of kidney and urinary tract sarcomatoid renal cell carcinoma collecting duct carcinoma familial prostate carcinoma papillary renal cell carcinoma renal hypomagnesemia 2 testicular germ cell tumor estrogen-receptor negative breast cancer frontotemporal dementia large cell medulloblastoma acquired metabolic disease nonpapillary renal cell carcinoma breast carcinoma ovarian carcinoma clear cell renal carcinoma Prostatic Neoplasms diabetes mellitus endometrial cancer exocrine pancreatic carcinoma gallbladder disease lung adenocarcinoma benign prostatic hyperplasia osteosarcoma cholestasis ovarian endometrioid adenocarcinoma prostate cancer, hereditary, 11 psoriasis squamous cell lung carcinoma endometrial carcinoma unilateral multicystic dysplastic kidney lung cancer ovarian cancer prostate carcinoma colorectal cancer renal carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.