Annotations: 2H4M

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2h4ma_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2h4mb_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	automated matches	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8038551	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13513	e2h4mA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13513	ECOD (1.6)
B	PF13513	e2h4mB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF13513	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03810	Importin-beta N-terminal domain (IBN_N)	Importin-beta N-terminal domain	-	Repeat
A, B	PF13513	HEAT-like repeat (HEAT_EZ)	HEAT-like repeat	-	Repeat
A, B	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat
C, D	PF11627	Heterogeneous nuclear ribonucleoprotein A1, LC domain (HnRNPA1_LC)	Heterogeneous nuclear ribonucleoprotein A1, LC domain	This entry includes hnRNPA1, a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins are involved in numerous RNA-related activities [1]. hnRNPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly ...	This entry includes hnRNPA1, a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins are involved in numerous RNA-related activities [1]. hnRNPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection [2]. hnRNPA1 plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform [3]. This protein binds to the IRES and inhibits the translation of the apoptosis protease activating factor APAF1. During Enterovirus 71 (EV71) infection, APAF1 expression is essential for virus-induced apoptosis and viral particle release [4]. HnRNPA1 has two RNA recognition motifs (RRM1 and RRM2) followed by an unstructured low complexity (LC) C-terminal domain, represented in this entry [5]. This domain can mediate protein-protein and protein-RNA interactions and it is involved in amyloid aggregation, leading to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP) [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transportin-1	small GTPase binding protein binding binding enzyme binding GTPase binding nuclear import signal receptor activity nucleocytoplasmic carrier activity molecular carrier activity RNA binding organic cyclic compound binding nucleic acid binding nuclear localization sequence binding signal sequence binding peptide binding	protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus cellular process intracellular protein transport	membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-bounded organelle cell projection organelle cilium cellular anatomical entity plasma membrane bounded cell projection extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle
C, D	Heterogeneous nuclear ribonucleoprotein A1	pre-mRNA binding RNA binding binding organic cyclic compound binding nucleic acid binding protein binding protein domain specific binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity mRNA 3'-UTR binding mRNA binding single-stranded RNA binding regulatory RNA binding pre-mRNA binding RNA binding binding organic cyclic compound binding nucleic acid binding protein binding protein domain specific binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity mRNA 3'-UTR binding mRNA binding single-stranded RNA binding regulatory RNA binding miRNA binding telomeric repeat-containing RNA binding DNA binding sequence-specific DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding telomeric DNA binding identical protein binding	localization cellular localization import into nucleus nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization cellular response to stimulus cellular response to arsenic-containing substance response to stimulus response to sodium arsenite localization cellular localization import into nucleus nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport cellular process establishment of localization cellular response to stimulus cellular response to arsenic-containing substance response to stimulus response to sodium arsenite response to arsenic-containing substance response to inorganic substance cellular response to chemical stimulus response to chemical cellular response to salt cellular response to sodium arsenite response to salt RNA transport nitrogen compound transport organic substance transport nucleic acid transport mRNA transport establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to glucose starvation cellular response to starvation organonitrogen compound metabolic process primary metabolic process amyloid fibril formation cellular component organization organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process cellular component organization or biogenesis supramolecular fiber organization regulation of cellular process alternative mRNA splicing, via spliceosome cellular biosynthetic process RNA metabolic process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance biosynthetic process RNA processing regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of mRNA processing RNA splicing regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of RNA splicing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process RNA splicing, via transesterification reactions regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of macromolecule biosynthetic process regulation of mRNA metabolic process regulation of metabolic process negative regulation of telomere maintenance negative regulation of biological process telomere organization negative regulation of telomere maintenance via telomerase regulation of DNA biosynthetic process negative regulation of cellular metabolic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of nucleobase-containing compound metabolic process negative regulation of cellular component organization negative regulation of metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization negative regulation of cellular biosynthetic process telomere maintenance negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization negative regulation of telomere maintenance via telomere lengthening nucleic acid biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process telomere maintenance via telomerase chromosome organization nucleobase-containing compound biosynthetic process regulation of telomere maintenance via telomerase organelle organization negative regulation of organelle organization negative regulation of biosynthetic process negative regulation of DNA metabolic process RNA export from nucleus nuclear export positive regulation of organelle organization positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase positive regulation of cellular component organization positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of DNA biosynthetic process positive regulation of cellular biosynthetic process	membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR040122	Importin beta family	Family
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR001494	Importin-beta, N-terminal domain	Domain
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR000357	HEAT repeat	Repeat
C, D	IPR034516	hnRNP A1/3, RNA recognition motif 2	Domain
C, D	IPR000504	RNA recognition motif domain	Domain
C, D	IPR021662	Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal	Domain
C, D	IPR034845	hnRNP A1, RNA recognition motif 1	Domain
C, D	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
C, D	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q92973	malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acne pilocytic astrocytoma atopic eczema psoriasis chronic obstructive pulmonary disease subependymal giant cell astrocytoma esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma malignant pancreatic neoplasm non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acne pilocytic astrocytoma atopic eczema psoriasis chronic obstructive pulmonary disease subependymal giant cell astrocytoma esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Alzheimer disease plasma cell myeloma atrial fibrillation rheumatoid arthritis Crohn disease tuberculosis exocrine pancreatic carcinoma invasive ductal breast carcinoma lung cancer malignant glioma myopathy osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease astrocytic tumor primitive neuroectodermal tumor atypical teratoid rhabdoid tumor Sjogren syndrome dermatomyositis ulcerative colitis glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma
C, D	Pharos: P09651	amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 20 inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 sarcomatoid carcinoma inclusion body myopathy with Paget disease of bone and frontotemporal dementia Mammary Neoplasms, Experimental carcinoma lymphoplasmacytic lymphoma medulloblastoma neurodegenerative disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor primitive neuroectodermal tumor lung adenocarcinoma amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 20 inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 sarcomatoid carcinoma inclusion body myopathy with Paget disease of bone and frontotemporal dementia Mammary Neoplasms, Experimental carcinoma lymphoplasmacytic lymphoma medulloblastoma neurodegenerative disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor primitive neuroectodermal tumor lung adenocarcinoma malignant colon neoplasm mammary neoplasms, animal myopathy oligodendroglioma pancreatic ductal adenocarcinoma Pick disease atypical teratoid rhabdoid tumor progressive supranuclear palsy undifferentiated carcinoma glioblastoma inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1 lung cancer malignant ependymoma nasopharyngeal carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma arthrogryposis plasma cell myeloma psoriasis dermatomyositis large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.