2GUZ

Structure of the Tim14-Tim16 complex of the mitochondrial protein import motor

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Chaperone J-domain	8051847	3000721	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Chaperone J-domain	8051847	3000721	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Chaperone J-domain	8051847	3000721	SCOP2B (2022-06-29)
H	SCOP2 Family	Pam16-like	8044674	4004074	SCOP2 (2022-06-29)
H	SCOP2 Superfamily	Chaperone J-domain	8051847	3000721	SCOP2 (2022-06-29)
J	SCOP2B Superfamily	Chaperone J-domain	8051847	3000721	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Chaperone J-domain	8051847	3000721	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Chaperone J-domain	8051847	3000721	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Chaperone J-domain	8051847	3000721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2guzA1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e2guzC1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e2guzG1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
K	F_UNCLASSIFIED	e2guzK1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e2guzE1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
I	F_UNCLASSIFIED	e2guzI1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
M	F_UNCLASSIFIED	e2guzM1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
O	F_UNCLASSIFIED	e2guzO1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF03656	e2guzB1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)
D	PF03656	e2guzD1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)
F	PF03656	e2guzF1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)
H	PF03656	e2guzH1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)
J	PF03656	e2guzJ1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)
L	PF03656	e2guzL1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)
N	PF03656	e2guzN1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)
P	PF03656	e2guzP1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF03656	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
C	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
G	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
K	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
E	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
I	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
M	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
O	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
B	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
D	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
F	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
H	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
J	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
L	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
N	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
P	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D, F, H, J B, D, F, H, J, L, N, P	PF03656	Pam16 (Pam16)	Pam16	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O	Mitochondrial import inner membrane translocase subunit TIM14	ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport protein transmembrane import into intracellular organelle protein targeting protein import into mitochondrial matrix protein transmembrane transport mitochondrial transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion establishment of protein localization to organelle protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial protein-containing complex protein-containing complex TIM23 mitochondrial import inner membrane translocase complex membrane protein complex inner mitochondrial membrane protein complex membrane-enclosed lumen PAM complex, Tim23 associated import motor mitochondrial matrix intracellular organelle lumen organelle lumen
B, D, F, H, J B, D, F, H, J, L, N, P	Mitochondrial import inner membrane translocase subunit TIM16	protein binding binding protein domain specific binding	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport protein transmembrane import into intracellular organelle protein targeting protein import into mitochondrial matrix protein transmembrane transport mitochondrial transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion establishment of protein localization to organelle protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial protein-containing complex protein-containing complex TIM23 mitochondrial import inner membrane translocase complex membrane protein complex inner mitochondrial membrane protein complex membrane-enclosed lumen PAM complex, Tim23 associated import motor mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M, O	IPR001623	DnaJ domain	Domain
A, C, E, G, I A, C, E, G, I, K, M, O	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P	IPR005341	Mitochondrial import inner membrane translocase subunit Tim16	Family
B, D, F, H, J B, D, F, H, J, L, N, P	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.