2GO5

Structure of signal recognition particle receptor (SR) in complex with signal recognition particle (SRP) and ribosome nascent chain complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth W]	d2go5w1	All alpha proteins	Signal peptide-binding domain	Signal peptide-binding domain	Signal peptide-binding domain	SRP54M	(Canis sp. ) [TaxId: 9616 ],	SCOPe (2.08)
C [auth B]	d2go5b1	Alpha and beta proteins (a+b)	SRP19	SRP19	SRP19	SRP19	(Canis sp. ) [TaxId: 9616 ],	SCOPe (2.08)
E [auth 1]	d2go511	Alpha and beta proteins (a+b)	Profilin-like	SNARE-like	SRP alpha N-terminal domain-like	Signal recognition particle receptor alpha subunit, N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth 1]	d2go512	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth 2]	d2go521	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Signal recognition particle receptor beta-subunit	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
H [auth 4]	SCOP2 Family	L23p	8061169	4000943	SCOP2 (2022-06-29)
H [auth 4]	SCOP2 Superfamily	Ribosomal proteins S24e L23 and L15e	8077093	3000210	SCOP2 (2022-06-29)
C [auth B]	SCOP2 Family	SRP19	8101640	4003420	SCOP2 (2022-06-29)
C [auth B]	SCOP2 Superfamily	SRP19	8101641	3000831	SCOP2 (2022-06-29)
E [auth 1]	SCOP2B Superfamily	SNARE-like	8040933	3001113	SCOP2B (2022-06-29)
F [auth 2]	SCOP2B Superfamily	Ras-like P-loop GTPases	8040934	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth W]	SRP_SPB	e2go5W2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: SRP_SPB	ECOD (1.6)
G [auth 5]	Ribosomal_L29_1	e2go551	A: alpha bundles	X: Long alpha-hairpin	H: Ribosomal protein L29 (L29p) (From Topology)	T: Ribosomal protein L29 (L29p)	F: Ribosomal_L29_1	ECOD (1.6)
H [auth 4]	Ribosomal_L23_3	e2go541	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal proteins S24e, L23 and L15e (From Topology)	T: Ribosomal proteins S24e, L23 and L15e	F: Ribosomal_L23_3	ECOD (1.6)
C [auth B]	SRP19	e2go5B1	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: SRP19	ECOD (1.6)
E [auth 1]	SRP-alpha_N	e2go511	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: SRP-alpha_N	ECOD (1.6)
F [auth 2]	MnmE_helical_2nd	e2go521	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
I [auth 6]	Ribosomal_L31e	e2go561	A: a+b two layers	X: Ribosomal protein L31e-like	H: Ribosomal protein L31e/gp120 outer domain (From Topology)	T: Ribosomal protein L31e/gp120 outer domain	F: Ribosomal_L31e	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth W]	PF02978	Signal peptide binding domain (SRP_SPB)	Signal peptide binding domain	-	Domain
G [auth 5]	PF00831	Ribosomal L29 protein (Ribosomal_L29)	Ribosomal L29 protein	-	Family
H [auth 4]	PF00276	Ribosomal protein L23 (Ribosomal_L23)	Ribosomal protein L23	-	Family
C [auth B]	PF01922	SRP19 protein (SRP19)	SRP19 protein	-	Family
E [auth 1]	PF04086	Signal recognition particle, alpha subunit, N-terminal (SRP-alpha_N)	Signal recognition particle, alpha subunit, N-terminal	-	Family
F [auth 2]	PF09439	Signal recognition particle receptor beta subunit (SRPRB)	Signal recognition particle receptor beta subunit	The beta subunit of the signal recognition particle receptor (SRP) is a transmembrane GTPase which anchors the alpha subunit to the endoplasmic reticulum membrane [1].	Domain
I [auth 6]	PF01198	Ribosomal protein L31e (Ribosomal_L31e)	Ribosomal protein L31e	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SRP RNA	-	-	-
D [auth W]	Signal recognition particle 54 kDa protein (SRP54)	endoplasmic reticulum signal peptide binding signal sequence binding binding peptide binding ribonucleoprotein complex binding protein-containing complex binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding endoplasmic reticulum signal peptide binding signal sequence binding binding peptide binding ribonucleoprotein complex binding protein-containing complex binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GDP binding RNA binding 7S RNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity GTPase activity	cell chemotaxis cellular response to stimulus chemotaxis response to stimulus neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis immune system process granulocyte chemotaxis response to chemical myeloid leukocyte migration cell chemotaxis cellular response to stimulus chemotaxis response to stimulus neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis immune system process granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cellular process cell motility leukocyte chemotaxis locomotion developmental process myeloid leukocyte differentiation cellular developmental process hemopoiesis cell development granulocyte differentiation myeloid cell differentiation cell differentiation anatomical structure development leukocyte differentiation protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER cellular component organization cellular component biogenesis cellular component assembly SRP-dependent cotranslational protein targeting to membrane protein-containing complex assembly cotranslational protein targeting to membrane cellular component organization or biogenesis SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition protein-containing complex organization establishment of protein localization to membrane localization within membrane protein localization to membrane protein targeting to membrane multicellular organismal process digestive system development gland development animal organ development exocrine pancreas development multicellular organism development pancreas development exocrine system development system development nitrogen compound transport transport protein transmembrane transport establishment of localization in cell intracellular protein transmembrane transport organic substance transport intracellular transport transmembrane transport protein transport SRP-dependent cotranslational protein targeting to membrane, translocation intracellular protein transport	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol signal recognition particle protein-containing complex signal recognition particle, endoplasmic reticulum targeting ribonucleoprotein complex endoplasmic reticulum endomembrane system
G [auth 5]	ribosomal protein L35	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding structural molecule activity structural constituent of ribosome	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process rRNA processing cellular component biogenesis nucleobase-containing compound metabolic process ribosome biogenesis organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis RNA processing rRNA metabolic process cellular metabolic process primary metabolic process gene expression ribosomal large subunit biogenesis macromolecule biosynthetic process nucleic acid metabolic process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) organic cyclic compound metabolic process biosynthetic process ncRNA metabolic process nucleic acid catabolic process cellular process metabolic process macromolecule metabolic process maturation of LSU-rRNA organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation protein metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle
H [auth 4]	ribosomal protein L23	structural molecule activity structural constituent of ribosome RNA binding binding organic cyclic compound binding rRNA binding nucleic acid binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex ribonucleoprotein complex membrane-bounded organelle intracellular organelle intracellular anatomical structure plastid organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle chloroplast intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle
B [auth 9]	ribosomal RNA	-	-	-
C [auth B]	Signal recognition particle 19 kDa protein (SRP19)	RNA binding 7S RNA binding binding organic cyclic compound binding nucleic acid binding	protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization SRP-dependent cotranslational protein targeting to membrane establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cotranslational protein targeting to membrane cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle signal recognition particle protein-containing complex signal recognition particle, endoplasmic reticulum targeting ribonucleoprotein complex cytoplasm nucleoplasm
E [auth 1]	Signal recognition particle receptor alpha subunit (SR a)	ribonucleoprotein complex binding protein-containing complex binding binding signal recognition particle binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity RNA binding organic cyclic compound binding ribonucleoprotein complex binding protein-containing complex binding binding signal recognition particle binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity RNA binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GTPase activity	protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane protein targeting to membrane cotranslational protein targeting to membrane establishment of protein localization to organelle protein localization to organelle establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER cellular component organization cellular component biogenesis cellular component assembly SRP-dependent cotranslational protein targeting to membrane protein-containing complex assembly cellular component organization or biogenesis SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition protein-containing complex organization	membrane cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure organelle subcompartment membrane protein complex intracellular membrane-bounded organelle endomembrane system rough endoplasmic reticulum endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle rough endoplasmic reticulum membrane membrane cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure organelle subcompartment membrane protein complex intracellular membrane-bounded organelle endomembrane system rough endoplasmic reticulum endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle rough endoplasmic reticulum membrane organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum signal recognition particle receptor complex cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle
F [auth 2]	Signal recognition particle receptor beta subunit (SR b)	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle cellular process establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER cellular component organization cellular component biogenesis cellular component assembly SRP-dependent cotranslational protein targeting to membrane protein-containing complex assembly cotranslational protein targeting to membrane cellular component organization or biogenesis SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition protein-containing complex organization establishment of protein localization to membrane localization within membrane protein localization to membrane protein targeting to membrane	polymeric cytoskeletal fiber intracellular anatomical structure cellular anatomical entity cytoplasmic microtubule intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton polymeric cytoskeletal fiber intracellular anatomical structure cellular anatomical entity cytoplasmic microtubule intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle membrane membrane-bounded organelle protein-containing complex organelle subcompartment membrane protein complex intracellular membrane-bounded organelle endomembrane system rough endoplasmic reticulum endoplasmic reticulum subcompartment bounding membrane of organelle rough endoplasmic reticulum membrane nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum signal recognition particle receptor complex organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
I [auth 6]	ribosomal protein L31	structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex ribonucleoprotein complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle ribosome cellular anatomical entity non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D [auth W]	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain	Domain
D [auth W]	IPR004125	Signal recognition particle, SRP54 subunit, M-domain	Domain
D [auth W]	IPR003593	AAA+ ATPase domain	Domain
D [auth W]	IPR013822	Signal recognition particle SRP54, helical bundle	Domain
D [auth W]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth W]	IPR022941	Signal recognition particle, SRP54 subunit	Family
D [auth W]	IPR036225	SRP/SRP receptor, N-terminal	Homologous Superfamily
D [auth W]	IPR042101	Signal recognition particle SRP54, N-terminal domain superfamily	Homologous Superfamily
D [auth W]	IPR006325	Signal recognition particle, SRP54 subunit, eukaryotic	Family
D [auth W]	IPR036891	Signal recognition particle, SRP54 subunit, M-domain superfamily	Homologous Superfamily
G [auth 5]	IPR045059	Large ribosomal subunit protein uL29, eukaryotes	Family
G [auth 5]	IPR001854	Large ribosomal subunit protein uL29	Family
G [auth 5]	IPR036049	Large ribosomal subunit protein uL29 superfamily	Homologous Superfamily
H [auth 4]	IPR012678	Ribosomal protein uL23/eL15/eS24 core domain superfamily	Homologous Superfamily
H [auth 4]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
H [auth 4]	IPR019985	Large ribosomal subunit protein uL23	Family
H [auth 4]	IPR001014	Large ribosomal subunit protein uL23, conserved site	Conserved Site
H [auth 4]	IPR013025	Large ribosomal subunit protein uL23-like	Family
C [auth B]	IPR002778	Signal recognition particle, SRP19 subunit	Family
C [auth B]	IPR036521	Signal recognition particle, subunit SRP19-like superfamily	Homologous Superfamily
E [auth 1]	IPR000897	Signal recognition particle, SRP54 subunit, GTPase domain	Domain
E [auth 1]	IPR036225	SRP/SRP receptor, N-terminal	Homologous Superfamily
E [auth 1]	IPR011012	Longin-like domain superfamily	Homologous Superfamily
E [auth 1]	IPR042101	Signal recognition particle SRP54, N-terminal domain superfamily	Homologous Superfamily
E [auth 1]	IPR003593	AAA+ ATPase domain	Domain
E [auth 1]	IPR007222	Signal recognition particle receptor, alpha subunit, N-terminal	Domain
E [auth 1]	IPR013822	Signal recognition particle SRP54, helical bundle	Domain
E [auth 1]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth 2]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth 2]	IPR019009	Signal recognition particle receptor, beta subunit	Family
I [auth 6]	IPR023621	Large ribosomal subunit protein eL31 domain superfamily	Homologous Superfamily
I [auth 6]	IPR000054	Large ribosomal subunit protein eL31	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth 1]	Pharos: P08240	astrocytic tumor osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Gaucher disease ovarian cancer malignant pancreatic neoplasm pancreatic ductal adenocarcinoma