Annotations: 2GLJ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02127	e2gljA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
A	PF02127	e2gljA2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
B	PF02127	e2gljB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
B	PF02127	e2gljB2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
C	PF02127	e2gljC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
C	PF02127	e2gljC2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
D	PF02127	e2gljD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
D	PF02127	e2gljD2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
E	PF02127	e2gljE1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
E	PF02127	e2gljE2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
F	PF02127	e2gljF1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
F	PF02127	e2gljF2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
G	PF02127	e2gljG1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
G	PF02127	e2gljG2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
H	PF02127	e2gljH1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
H	PF02127	e2gljH2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
I	PF02127	e2gljI1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
I	PF02127	e2gljI2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
J	PF02127	e2gljJ1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
J	PF02127	e2gljJ2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
K	PF02127	e2gljK1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
K	PF02127	e2gljK2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
L	PF02127	e2gljL4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
L	PF02127	e2gljL3	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
M	PF02127	e2gljM1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
M	PF02127	e2gljM2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
N	PF02127	e2gljN1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
N	PF02127	e2gljN2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
O	PF02127	e2gljO1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
O	PF02127	e2gljO2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
P	PF02127	e2gljP1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
P	PF02127	e2gljP2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
Q	PF02127	e2gljQ1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
Q	PF02127	e2gljQ2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
R	PF02127	e2gljR1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
R	PF02127	e2gljR2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
S	PF02127	e2gljS1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
S	PF02127	e2gljS2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
T	PF02127	e2gljT1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
T	PF02127	e2gljT2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
U	PF02127	e2gljU1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
U	PF02127	e2gljU2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
V	PF02127	e2gljV1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
V	PF02127	e2gljV2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
W	PF02127	e2gljW1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
W	PF02127	e2gljW2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)
X	PF02127	e2gljX1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF02127	ECOD (1.6)
X	PF02127	e2gljX2	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF02127	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
A	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
B	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
B	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
C	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
C	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
D	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
D	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
E	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
E	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
F	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
F	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
G	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
G	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
H	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
H	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
I	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
I	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
J	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
J	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
K	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
K	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
L	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
L	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
M	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
M	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
N	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
N	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
O	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
O	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
P	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
P	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
Q	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
Q	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
R	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
R	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
S	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
S	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
T	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
T	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
U	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
U	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
V	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
V	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
W	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
W	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)
X	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
X	2.30.250.10	Mainly Beta	Roll	Aminopeptidase i, Domain 2	Aminopeptidase i, Domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PF02127	Aminopeptidase I zinc metalloprotease (M18) (Peptidase_M18)	Aminopeptidase I zinc metalloprotease (M18)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	Probable M18-family aminopeptidase 1	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding aminopeptidase activity exopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR022983	M18 family aminopeptidase 1, putative	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR023358	Peptidase M18, domain 2	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR001948	Peptidase M18	Family