2GL7

Crystal Structure of a beta-catenin/BCL9/Tcf4 complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2gl7a_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	beta-Catenin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2gl7d_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	beta-Catenin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8040103	3000116	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ARM repeat-like	8040103	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	BCL9 beta-catenin binding domain-like	8102721	3002739	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00514	e2gl7A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00514	ECOD (1.6)
D	PF00514	e2gl7D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00514	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
D	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
B, E	PF08347	N-terminal CTNNB1 binding (CTNNB1_binding)	N-terminal CTNNB1 binding	-	Family
C, F	PF11502	B-cell lymphoma 9 protein (BCL9)	B-cell lymphoma 9 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Beta-catenin	protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cell adhesion molecule binding cadherin binding histone methyltransferase binding transcription coregulator binding transcription corepressor binding nuclear estrogen receptor binding I-SMAD binding protein-containing complex binding chromatin binding transmembrane transporter binding disordered domain specific binding protein domain specific binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development oviduct development reproductive system development reproductive process developmental process involved in reproduction reproductive structure development dorsal/ventral pattern formation dorsal/ventral axis specification pattern specification process axis specification regionalization regulation of cellular process cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development neurogenesis cell differentiation cellular process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cell population proliferation regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation smooth muscle cell proliferation embryonic skeletal joint development limb development chordate embryonic development embryonic limb morphogenesis embryonic appendage morphogenesis embryo development embryonic skeletal joint morphogenesis embryo development ending in birth or egg hatching skeletal system development animal organ morphogenesis embryonic organ development embryonic skeletal system morphogenesis embryonic organ morphogenesis embryonic skeletal limb joint morphogenesis appendage development embryonic morphogenesis animal organ development appendage morphogenesis limb joint morphogenesis embryonic skeletal system development skeletal system morphogenesis limb morphogenesis heart morphogenesis cardioblast proliferation regulation of cardioblast proliferation animal organ formation regulation of secondary heart field cardioblast proliferation heart development heart formation cell proliferation involved in heart morphogenesis regulation of cell proliferation involved in heart morphogenesis response to fibroblast growth factor positive regulation of cell communication cellular response to growth factor stimulus positive regulation of signal transduction positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling response to endogenous stimulus regulation of cellular response to growth factor stimulus regulation of response to stimulus fibroblast growth factor receptor signaling pathway regulation of cell communication response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway positive regulation of signaling regulation of timing of anagen epidermis development molting cycle process anagen hair cycle phase skin epidermis development hair follicle development hair follicle maturation regulation of hair follicle maturation epithelium development biological phase hair cycle developmental maturation tissue development skin development anatomical structure maturation molting cycle hair cycle process maintenance of cell number stem cell population maintenance prostate gland development gland development epithelial cell proliferation involved in prostate gland development urogenital system development epithelial cell proliferation trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission detection of external stimulus detection of stimulus detection of mechanical stimulus detection of muscle stretch response to mechanical stimulus response to external stimulus response to abiotic stimulus detection of abiotic stimulus response to muscle stretch adherens junction organization adherens junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis cell-cell junction organization cell-cell junction assembly negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of gliogenesis negative regulation of neurogenesis gliogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process regulation of glial cell differentiation negative regulation of gliogenesis negative regulation of cell development negative regulation of oligodendrocyte differentiation negative regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation negative regulation of multicellular organismal process regulation of oligodendrocyte differentiation positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of sulfur metabolic process sulfur compound metabolic process positive regulation of macromolecule metabolic process positive regulation of heparan sulfate proteoglycan biosynthetic process regulation of protein metabolic process regulation of heparan sulfate proteoglycan biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process sulfur compound biosynthetic process proteoglycan metabolic process positive regulation of proteoglycan biosynthetic process proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of sulfur metabolic process positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of biosynthetic process protein metabolic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process positive regulation of cellular biosynthetic process epidermal cell differentiation epithelial cell differentiation hair cell differentiation generation of neurons neuron differentiation negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death protein localization localization cellular localization protein localization to cell surface cellular macromolecule localization macromolecule localization sexual reproduction multicellular organismal reproductive process oogenesis cellular process involved in reproduction in multicellular organism female gamete generation gamete generation oocyte development germ cell development oocyte differentiation developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell growth cell morphogenesis cell projection morphogenesis neuron projection morphogenesis neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth developmental growth involved in morphogenesis neuron development branching morphogenesis of an epithelial tube respiratory tube development lung morphogenesis lung development respiratory system development epithelial tube morphogenesis morphogenesis of an epithelium tissue morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium sympathetic nervous system development ganglion development autonomic nervous system development sympathetic ganglion development positive regulation of mesenchymal cell proliferation positive regulation of cell population proliferation regulation of mesenchymal cell proliferation mesenchymal cell proliferation synapse organization vesicle localization transport synaptic vesicle clustering synaptic vesicle cycle establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse organelle localization establishment of localization in cell synaptic vesicle localization cell maturation anterior/posterior axis specification anterior/posterior pattern specification positive regulation of odontoblast differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation neuroepithelial cell differentiation odontoblast differentiation regulation of odontoblast differentiation positive regulation of epithelial cell differentiation columnar/cuboidal epithelial cell differentiation positive regulation of neuroepithelial cell differentiation apoptotic signaling pathway myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis lens morphogenesis in camera-type eye sensory organ morphogenesis camera-type eye development sensory system development lens development in camera-type eye negative regulation of blood vessel morphogenesis negative regulation of angiogenesis negative regulation of vasculature development negative regulation of post-translational protein modification regulation of protein sumoylation regulation of protein modification process peptidyl-lysine modification peptidyl-amino acid modification negative regulation of protein modification process protein modification process regulation of protein modification by small protein conjugation or removal negative regulation of protein sumoylation negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein sumoylation macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal outflow tract morphogenesis cell fate specification cell fate commitment forebrain development glial cell migration telencephalon glial cell migration cerebral cortex development telencephalon cell migration forebrain cell migration cell migration cell motility layer formation in cerebral cortex cerebral cortex cell migration head development brain development cerebral cortex radially oriented cell migration pallium development cerebral cortex radial glia-guided migration telencephalon development hindbrain development positive regulation of gene expression regulation of stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation in utero embryonic development intracellular signal transduction intracellular signaling cassette MAPK cascade cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process T cell differentiation neuron fate commitment cell fate determination neuron fate determination positive regulation of determination of dorsal identity regulation of determination of dorsal identity determination of bilateral symmetry determination of dorsal/ventral asymmetry positive regulation of multicellular organismal process determination of dorsal identity specification of symmetry intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process negative regulation of signaling negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of response to stimulus negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of signal transduction neuron intrinsic apoptotic signaling pathway in response to oxidative stress negative regulation of intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation stem cell differentiation mesenchymal stem cell differentiation mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron development nephron epithelium development ureteric bud development mesonephros development kidney morphogenesis mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis microtubule organizing center organization regulation of cell cycle process microtubule cytoskeleton organization centriole-centriole cohesion organelle organization centrosome cycle microtubule-based process cell cycle regulation of cell cycle regulation of centriole-centriole cohesion cytoskeleton organization cell cycle process multicellular organismal-level homeostasis homeostatic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption ossification osteoblast differentiation immune system development hematopoietic or lymphoid organ development thymus development transcription by RNA polymerase II cranial ganglion development nerve development cranial nerve development foregut regionalization developmental induction regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis specification of animal organ identity regulation of branching involved in lung morphogenesis regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud morphogenesis of an epithelial fold morphogenesis of embryonic epithelium regulation of embryonic development lung field specification lung induction primary lung bud formation positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction glial cell fate determination glial cell fate commitment pancreas development positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade embryonic axis specification embryonic pattern specification positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process dopaminergic neuron differentiation midbrain development midbrain dopaminergic neuron differentiation neuron migration regulation of transcription by RNA polymerase II regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II positive regulation of transcription by RNA polymerase II transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription, elongation DNA-templated transcription elongation response to chemical response to xenobiotic stimulus epithelial cell differentiation involved in prostate gland development digestive system development foregut morphogenesis digestive tract development embryonic foregut morphogenesis digestive tract morphogenesis myoblast proliferation astrocyte-dopaminergic neuron signaling glial cell-neuron signaling regulation of epithelial cell differentiation involved in kidney development regulation of nephron tubule epithelial cell differentiation epithelial cell differentiation involved in kidney development nephron tubule epithelial cell differentiation cell differentiation involved in kidney development establishment of organelle localization establishment of vesicle localization synaptic vesicle transport dorsal root ganglion development genitalia development sex differentiation male sex differentiation male genitalia development endothelium development morphogenesis of an endothelium endothelial tube morphogenesis epidermis morphogenesis hair follicle morphogenesis embryonic hindlimb morphogenesis hindlimb morphogenesis mesenchymal cell proliferation involved in lung development branching involved in blood vessel morphogenesis positive regulation of myoblast proliferation regulation of myoblast proliferation metanephros development metanephros morphogenesis positive regulation of organelle organization telomere organization regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of telomere maintenance via telomere lengthening positive regulation of telomere maintenance DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization telomere maintenance via telomerase chromosome organization positive regulation of DNA biosynthetic process regulation of telomere maintenance via telomerase positive regulation of endothelial cell differentiation endothelial cell differentiation regulation of endothelial cell differentiation regulation of synapse structure or activity regulation of synapse assembly regulation of biological quality regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization synapse assembly connective tissue development chondrocyte differentiation cartilage development negative regulation of transcription by RNA polymerase II formation of primary germ layer gastrulation cell fate commitment involved in formation of primary germ layer endoderm development endoderm formation endodermal cell fate commitment endodermal cell differentiation gastrulation with mouth forming second regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development epithelial to mesenchymal transition mesenchymal cell differentiation regulation of localization regulation of protein localization regulation of cellular localization regulation of protein localization to cell surface renal vesicle morphogenesis regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation involved in kidney development metanephric renal vesicle morphogenesis renal vesicle development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric nephron development mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation mesenchymal to epithelial transition metanephric nephron morphogenesis cell differentiation involved in metanephros development hypothalamus development diencephalon development limbic system development regulation of reproductive process regulation of epithelial cell proliferation involved in prostate gland development positive regulation of reproductive process positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation involved in prostate gland development regulation of epithelial cell proliferation regulation of mitotic cell cycle, embryonic negative regulation of cell cycle mitotic cell cycle negative regulation of mitotic cell cycle mitotic cell cycle, embryonic regulation of mitotic cell cycle negative regulation of mitotic cell cycle, embryonic organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process fibroblast proliferation regulation of fibroblast proliferation establishment of blood-retinal barrier acinar cell differentiation glandular epithelial cell differentiation muscle structure development smooth muscle cell differentiation muscle cell differentiation regulation of protein ubiquitination protein ubiquitination regulation of cartilage development regulation of chondrocyte differentiation negative regulation of cartilage development negative regulation of chondrocyte differentiation negative regulation of gene expression proximal/distal pattern formation response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound embryonic digit morphogenesis ectoderm development regulation of muscle tissue development skeletal muscle tissue development positive regulation of skeletal muscle tissue development regulation of skeletal muscle tissue development skeletal muscle organ development positive regulation of muscle tissue development muscle tissue development muscle organ development neuroblast proliferation neural precursor cell proliferation embryonic forelimb morphogenesis forelimb morphogenesis regulation of calcium ion import regulation of calcium ion transport regulation of transport regulation of monoatomic ion transport calcium ion transport metal ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport regulation of leukocyte activation regulation of cell activation leukocyte proliferation lymphocyte proliferation regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of T cell activation regulation of T cell proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of leukocyte differentiation regulation of osteoclast differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of immune system process regulation of hemopoiesis embryonic brain development protein polyubiquitination central nervous system vasculogenesis vasculogenesis genitalia morphogenesis sister chromatid cohesion centromeric sister chromatid cohesion regulation of centromeric sister chromatid cohesion regulation of sister chromatid cohesion cell adhesion lung epithelium development lung epithelial cell differentiation lung cell differentiation positive regulation of morphogenesis of an epithelium positive regulation of branching involved in lung morphogenesis neural plate development cell-matrix adhesion cell-substrate adhesion ectodermal placode morphogenesis hair follicle placode formation ectodermal placode formation ectodermal placode development regulation of myelination myelination axon ensheathment ensheathment of neurons establishment of blood-brain barrier lung-associated mesenchyme development odontogenesis of dentin-containing tooth odontogenesis cranial skeletal system development embryonic epithelial tube formation tube formation epithelial tube formation nephron tubule formation renal vesicle formation embryonic heart tube development trachea morphogenesis trachea formation trachea development negative regulation of cell population proliferation regulation of osteoblast differentiation positive regulation of osteoblast differentiation renal inner medulla development cellular response to nitrogen compound response to alcohol response to organonitrogen compound cellular response to organic cyclic compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol cellular response to organonitrogen compound response to indole-3-methanol cellular response to indole-3-methanol cellular response to organic substance cell-cell adhesion renal outer medulla development positive regulation of nervous system development regulation of neuroblast proliferation positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation tongue development fungiform papilla formation fungiform papilla development fungiform papilla morphogenesis tongue morphogenesis	membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola cellular anatomical entity membrane microdomain cell periphery flotillin complex plasma membrane region cell-cell junction membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola cellular anatomical entity membrane microdomain cell periphery flotillin complex plasma membrane region cell-cell junction intercalated disc anchoring junction cell junction fascia adherens cell-cell contact zone focal adhesion cell-substrate junction membrane-bounded organelle RNA polymerase II transcription regulator complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle beta-catenin-TCF7L2 complex intracellular organelle catenin-TCF7L2 complex organelle beta-catenin-TCF complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex Schaffer collateral - CA1 synapse synapse protein-DNA complex euchromatin chromatin chromosome intracellular non-membrane-bounded organelle non-membrane-bounded organelle cell projection cell leading edge plasma membrane bounded cell projection lamellipodium postsynapse postsynaptic membrane synaptic membrane cytoskeleton spindle spindle pole microtubule cytoskeleton Z disc sarcomere I band contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex apical part of cell extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle actin-based cell projection microvillus microvillus membrane cell projection membrane presynapse presynaptic membrane cell cortex cytoplasmic region presynaptic active zone cytoplasmic component cell cortex region presynaptic active zone extrinsic component of plasma membrane catenin complex extrinsic component of membrane Scrib-APC-beta-catenin complex glutamatergic synapse RNA polymerase II transcription repressor complex beta-catenin-ICAT complex transcription repressor complex adherens junction centrosome microtubule organizing center membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytosol lateral plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane perinuclear region of cytoplasm postsynaptic density, intracellular component postsynaptic specialization postsynaptic specialization, intracellular component postsynaptic density neuron to neuron synapse asymmetric synapse apicolateral plasma membrane Wnt signalosome apical junction complex bicellular tight junction tight junction
B, E	Transcription factor 7-like 2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity gamma-catenin binding protein binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding armadillo repeat domain binding protein domain specific binding kinase binding enzyme binding protein kinase binding nuclear receptor binding beta-catenin binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway developmental process muscle structure development cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development myoblast differentiation cell fate commitment myoblast fate commitment negative regulation of signaling regulation of canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication cell population proliferation regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation smooth muscle cell proliferation chromosome organization primary metabolic process DNA metabolic process maintenance of DNA repeat elements nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process metabolic process cellular component organization or biogenesis macromolecule metabolic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of type B pancreatic cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process type B pancreatic cell apoptotic process negative regulation of type B pancreatic cell apoptotic process negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process apoptotic process programmed cell death fat cell differentiation extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of apoptotic signaling pathway multicellular organism development multicellular organismal process vasculature development blood vessel development system development circulatory system development negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of protein binding positive regulation of molecular function regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process regulation of sulfur metabolic process sulfur compound metabolic process positive regulation of heparan sulfate proteoglycan biosynthetic process regulation of protein metabolic process regulation of heparan sulfate proteoglycan biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process sulfur compound biosynthetic process proteoglycan metabolic process positive regulation of proteoglycan biosynthetic process proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of sulfur metabolic process positive regulation of protein metabolic process protein metabolic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization negative regulation of DNA-binding transcription factor activity negative regulation of molecular function regulation of DNA-binding transcription factor activity regulation of hormone metabolic process regulation of hormone levels regulation of biological quality hormone metabolic process regulation of epithelial to mesenchymal transition regulation of developmental process positive regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development positive regulation of developmental process positive regulation of cell differentiation regulation of multicellular organismal process animal organ development tissue development epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling response to hexose response to organic substance response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound pancreas development monosaccharide metabolic process negative regulation of small molecule metabolic process gluconeogenesis negative regulation of gluconeogenesis regulation of small molecule metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process negative regulation of carbohydrate metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process glucose metabolic process establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of peptide hormone secretion organic substance transport positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion regulation of hormone secretion regulation of peptide secretion transport positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport positive regulation of protein secretion peptide transport positive regulation of transport protein transport regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion	intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle catenin-TCF7L2 complex nucleus nuclear protein-containing complex intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle catenin-TCF7L2 complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle RNA polymerase II transcription regulator complex transcription regulator complex beta-catenin-TCF7L2 complex beta-catenin-TCF complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body PML body
C, F	B-cell lymphoma 9 protein	transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity beta-catenin binding protein binding binding	developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication signal transduction Wnt signaling pathway tissue regeneration skeletal muscle tissue regeneration developmental growth growth myotube differentiation involved in skeletal muscle regeneration muscle cell differentiation regeneration myotube differentiation striated muscle cell differentiation cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process multicellular organismal process somatic stem cell population maintenance maintenance of cell number stem cell population maintenance positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process skeletal muscle cell differentiation skeletal muscle tissue development animal organ development tissue development skeletal muscle organ development muscle tissue development muscle organ development	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus cis-Golgi network organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm endomembrane system RNA polymerase II transcription regulator complex protein-containing complex nucleus nuclear protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus cis-Golgi network organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm endomembrane system RNA polymerase II transcription regulator complex protein-containing complex nucleus nuclear protein-containing complex transcription regulator complex beta-catenin-TCF complex sarcoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR016024	Armadillo-type fold	Homologous Superfamily
A, D	IPR000225	Armadillo	Repeat
A, D	IPR011989	Armadillo-like helical	Homologous Superfamily
A, D	IPR013284	Beta-catenin	Family
B, E	IPR013558	CTNNB1 binding, N-teminal	Domain
B, E	IPR027397	Catenin binding domain superfamily	Homologous Superfamily
B, E	IPR036910	High mobility group box domain superfamily	Homologous Superfamily
B, E	IPR024940	Transcription factor TCF/LEF	Family
B, E	IPR009071	High mobility group box domain	Domain
C, F	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
C, F	IPR015668	B Cell Lymphoma 9	Family
C, F	IPR024670	B-cell lymphoma 9, beta-catenin binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: P35222	medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma adrenal cortex carcinoma craniopharyngioma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma adrenal cortex carcinoma craniopharyngioma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor breast cancer cirrhosis of liver malignant mesothelioma breast carcinoma melanotic medulloblastoma prostate cancer liver cancer cecal neoplasm Aberrant Crypt Foci cervical cancer adenocarcinoma tubular adenocarcinoma papillary adenoma adult medulloblastoma malignant pancreatic neoplasm intellectual disability mantle cell lymphoma medullomyoblastoma with myogenic differentiation microcystic adenoma cecum cancer exudative vitreoretinopathy 7 childhood medulloblastoma follicular thyroid adenoma papillary craniopharyngioma intestinal cancer cancer adamantinous craniopharyngioma malignant colon neoplasm granular cell carcinoma adrenal gland cancer hepatocellular carcinoma parathyroid gland adenoma hereditary Wilms tumor atypical teratoid rhabdoid tumor desmoplastic/nodular medulloblastoma intestinal disease brain disease medulloblastoma with extensive nodularity drug-induced liver injury plasma cell myeloma kidney disease endometrial carcinoma psoriasis liver neoplasm exudative vitreoretinopathy 1 lung benign neoplasm non-small cell lung carcinoma stomach disease lymphatic system disease colon carcinoma gastric carcinoma malignant ependymoma ovarian neoplasm hematologic disease adrenal cortex adenoma uterine disease pancreatic intraductal papillary-mucinous neoplasm cribriform carcinoma cystadenoma peritoneal neoplasm benign colon neoplasm Perlman syndrome intestinal neoplasm breast disease endometriosis prostate disease esophageal squamous cell carcinoma lung disease osteoporosis toxic epidermal necrolysis colonic neoplasm ovarian carcinoma glioblastoma urinary bladder disease colorectal carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cribriform carcinoma of breast melanoma Emery-Dreifuss muscular dystrophy primitive neuroectodermal tumor large cell medulloblastoma endometrium carcinoma in situ liver disease schizophrenia lung adenocarcinoma osteosarcoma gastric adenocarcinoma tuberculosis colorectal adenocarcinoma ovarian disease adrenal carcinoma pancreatic intraductal papillary-mucinous carcinoma vertebral column disease pancreatic neoplasm adult hepatocellular carcinoma cutaneous melanoma
B, E	Pharos: Q9NQB0	type 2 diabetes mellitus colorectal cancer diabetes mellitus psoriasis tubular adenocarcinoma lung carcinoma breast carcinoma Neurodevelopmental Disorders adenocarcinoma granular cell carcinoma malignant colon neoplasm hyperplasia juvenile idiopathic arthritis metabolic syndrome X cribriform carcinoma type 2 diabetes mellitus colorectal cancer diabetes mellitus psoriasis tubular adenocarcinoma lung carcinoma breast carcinoma Neurodevelopmental Disorders adenocarcinoma granular cell carcinoma malignant colon neoplasm hyperplasia juvenile idiopathic arthritis metabolic syndrome X cribriform carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy Pick disease estrogen-receptor negative breast cancer primitive neuroectodermal tumor acquired metabolic disease glioblastoma inborn carbohydrate metabolic disorder schizophrenia astrocytic tumor benign colon neoplasm malignant glioma maturity-onset diabetes of the young coronary artery disease cribriform carcinoma of breast ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Emery-Dreifuss muscular dystrophy pilocytic astrocytoma exocrine pancreatic carcinoma rheumatoid arthritis adenoma interstitial cystitis juvenile dermatomyositis Sjogren syndrome atopic eczema bipolar disorder chronic kidney disease malignant mesothelioma colorectal carcinoma medulloblastoma oligodendroglioma dermatomyositis pancreatic intraductal papillary-mucinous carcinoma peripheral arterial disease esophageal adenocarcinoma pituitary cancer gestational diabetes prostate carcinoma schizoaffective disorder amyotrophic lateral sclerosis invasive ductal breast carcinoma thoracic aortic aneurysm atypical teratoid rhabdoid tumor large cell medulloblastoma breast cancer malignant ependymoma colonic neoplasm malignant pancreatic neoplasm
C, F	Pharos: O00512	chromosome 1q21.1 deletion syndrome bipolar disorder lung cancer malignant mesothelioma ovarian neoplasm schizophrenia cancer lung carcinoma Malignant neoplasm of ovary primitive neuroectodermal tumor thrombocytopenia-absent radius syndrome major depressive disorder ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.