2GCE

The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2gcea_	Alpha and beta proteins (a/b)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	2-methylacyl-CoA racemase Mcr	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
B	d2gceb_	Alpha and beta proteins (a/b)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	2-methylacyl-CoA racemase Mcr	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
C	d2gcec_	Alpha and beta proteins (a/b)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	2-methylacyl-CoA racemase Mcr	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
D	d2gced_	Alpha and beta proteins (a/b)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	2-methylacyl-CoA racemase Mcr	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	CoA-transferase family III (CaiB/BaiF)	8033648	3000607	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CoA-transferase family III (CaiB/BaiF)	8033648	3000607	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	CoA-transferase family III (CaiB/BaiF)	8033648	3000607	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CoA-transferase family III (CaiB/BaiF)	8033648	3000607	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CoA_transf_3	e2gceA1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: CoA_transf_3	ECOD (1.6)
B	CoA_transf_3	e2gceB1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: CoA_transf_3	ECOD (1.6)
C	CoA_transf_3	e2gceC1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: CoA_transf_3	ECOD (1.6)
D	CoA_transf_3	e2gceD1	A: a/b three-layered sandwiches	X: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	H: SurE-like/CoA-transferase family III (CaiB/BaiF) (From Topology)	T: SurE-like/CoA-transferase family III (CaiB/BaiF)	F: CoA_transf_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Crotonobetainyl-coa:carnitine coa-transferase	CATH (4.3.0)
A	3.30.1540.10	Alpha Beta	2-Layer Sandwich	formyl-coa transferase, domain 3	formyl-coa transferase, domain 3	CATH (4.3.0)
B	3.40.50.10540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Crotonobetainyl-coa:carnitine coa-transferase	CATH (4.3.0)
B	3.30.1540.10	Alpha Beta	2-Layer Sandwich	formyl-coa transferase, domain 3	formyl-coa transferase, domain 3	CATH (4.3.0)
C	3.40.50.10540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Crotonobetainyl-coa:carnitine coa-transferase	CATH (4.3.0)
C	3.30.1540.10	Alpha Beta	2-Layer Sandwich	formyl-coa transferase, domain 3	formyl-coa transferase, domain 3	CATH (4.3.0)
D	3.40.50.10540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Crotonobetainyl-coa:carnitine coa-transferase	CATH (4.3.0)
D	3.30.1540.10	Alpha Beta	2-Layer Sandwich	formyl-coa transferase, domain 3	formyl-coa transferase, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02515	CoA-transferase family III (CoA_transf_3)	CoA-transferase family III	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	probable alpha-methylacyl-CoA racemase MCR	isomerase activity racemase and epimerase activity alpha-methylacyl-CoA racemase activity catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR023606	CoA-transferase family III domain 1 superfamily	Homologous Superfamily
A, B, C, D	IPR044855	CoA-transferase family III domain 3 superfamily	Homologous Superfamily
A, B, C, D	IPR003673	CoA-transferase family III	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.