2G64

Structure of Caenorhabditis elegans 6-pyruvoyl tetrahydropterin synthase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2g64a1	Alpha and beta proteins (a+b)	T-fold	Tetrahydrobiopterin biosynthesis enzymes-like	6-pyruvoyl tetrahydropterin synthase	6-pyruvoyl tetrahydropterin synthase	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	6-pyruvoyl tetrahydropterin synthase	8029332	4001717	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Tetrahydrobiopterin biosynthesis enzymes-like	8041711	3000283	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01242	e2g64A1	A: a+b two layers	X: T-fold	H: Tetrahydrobiopterin biosynthesis enzymes-like (From Topology)	T: Tetrahydrobiopterin biosynthesis enzymes-like	F: PF01242	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.479.10	Alpha Beta	2-Layer Sandwich	Tetrahydropterin Synthase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01242	6-pyruvoyl tetrahydropterin synthase (PTPS)	6-pyruvoyl tetrahydropterin synthase	6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer ...	6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Putative 6-pyruvoyl tetrahydrobiopterin synthase	cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding carbon-oxygen lyase activity, acting on phosphates 6-pyruvoyltetrahydropterin synthase activity lyase activity catalytic activity carbon-oxygen lyase activity	polyol metabolic process organonitrogen compound metabolic process small molecule biosynthetic process organic hydroxy compound metabolic process organonitrogen compound biosynthetic process alcohol metabolic process diol biosynthetic process organic cyclic compound metabolic process organic substance metabolic process diol metabolic process biosynthetic process tetrahydrobiopterin biosynthetic process organic cyclic compound biosynthetic process tetrahydrobiopterin metabolic process organic hydroxy compound biosynthetic process polyol metabolic process organonitrogen compound metabolic process small molecule biosynthetic process organic hydroxy compound metabolic process organonitrogen compound biosynthetic process alcohol metabolic process diol biosynthetic process organic cyclic compound metabolic process organic substance metabolic process diol metabolic process biosynthetic process tetrahydrobiopterin biosynthetic process organic cyclic compound biosynthetic process tetrahydrobiopterin metabolic process organic hydroxy compound biosynthetic process pteridine-containing compound biosynthetic process organic substance biosynthetic process polyol biosynthetic process alcohol biosynthetic process metabolic process small molecule metabolic process pteridine-containing compound metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022470	6-pyruvoyl tetrahydropterin synthase, cysteine active site	Active Site
A	IPR038418	6-pyruvoyl tetrahydropterin synthase/QueD superfamily	Homologous Superfamily
A	IPR007115	6-pyruvoyl tetrahydropterin synthase/QueD family	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.