2FP8

Structure of Strictosidine Synthase, the Biosynthetic Entry to the Monoterpenoid Indole Alkaloid Family

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SGL_1	e2fp8A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: SGL_1	ECOD (1.6)
B	SGL_1	e2fp8B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: SGL_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
B	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03088	Strictosidine synthase (Str_synth)	Strictosidine synthase	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Strictosidine synthase	amine-lyase activity lyase activity catalytic activity strictosidine synthase activity carbon-nitrogen lyase activity	organonitrogen compound metabolic process organic substance metabolic process alkaloid metabolic process metabolic process biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle vacuole cytoplasm cellular anatomical entity intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A, B	IPR018119	Strictosidine synthase, conserved region	Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	strictosidine synthase M-CSA #360	Strictosidine synthase is an unusual six-bladed beta-propeller fold protein which catalyses the condensation of two precursor molecules, tryptamine and monoterpenoid secologanin to form strictosidine. This molecule is the generic starting material for the biosynthetic formation of monoterpenoid-derived indole alkaloids, many of which are known to have potent therapeutic characteristics, including anti-cancer properties.	Defined by 1 residue: GLU:A-287 [auth A-309] \| Explore in 3D: M-CSA Motif Definition At least 2 residues must be present to support Structure Motif searching. EC: 4.3.3.2 (PDB Primary Data)

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.