2FLI

The crystal structure of D-ribulose 5-phosphate 3-epimerase from Streptococus pyogenes complexed with D-xylitol 5-phosphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2flia1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	D-ribulose-5-phosphate 3-epimerase	D-ribulose-5-phosphate 3-epimerase	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
B	d2flib_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
C	d2flic_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
D	d2flid_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
E	d2flie_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
F	d2flif_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
G	d2flig_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
H	d2flih_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
I	d2flii_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
J	d2flij_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
K	d2flik_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)
L	d2flil_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Ribulose-phoshate binding barrel	automated matches	automated matches	(Streptococcus pyogenes ) [TaxId: 1314 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	D-ribulose-5-phosphate 3-epimerase	8028751	4003059	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Ribulose-phoshate binding barrel	8041130	3000216	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ribul_P_3_epim	e2fliA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
B	Ribul_P_3_epim	e2fliB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
C	Ribul_P_3_epim	e2fliC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
D	Ribul_P_3_epim	e2fliD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
E	Ribul_P_3_epim	e2fliE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
F	Ribul_P_3_epim	e2fliF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
G	Ribul_P_3_epim	e2fliG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
H	Ribul_P_3_epim	e2fliH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
I	Ribul_P_3_epim	e2fliI1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
J	Ribul_P_3_epim	e2fliJ1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
K	Ribul_P_3_epim	e2fliK1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)
L	Ribul_P_3_epim	e2fliL1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Ribul_P_3_epim	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
E	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
F	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
G	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
H	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
I	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
J	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
K	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
L	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00834	Ribulose-phosphate 3 epimerase family (Ribul_P_3_epim)	Ribulose-phosphate 3 epimerase family	This enzyme catalyses the conversion of D-ribulose 5-phosphate into D-xylulose 5-phosphate.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	ribulose-phosphate 3-epimerase	isomerase activity racemase and epimerase activity D-ribulose-phosphate 3-epimerase activity racemase and epimerase activity, acting on carbohydrates and derivatives catalytic activity cation binding ion binding binding metal ion binding small molecule binding	carbohydrate derivative metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process carbohydrate derivative metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process organic substance metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process generation of precursor metabolites and energy nucleotide metabolic process purine-containing compound metabolic process NADP metabolic process organic cyclic compound metabolic process NADPH regeneration organophosphate metabolic process metabolic process cellular process monosaccharide metabolic process carbohydrate metabolic process catabolic process carbohydrate catabolic process monosaccharide catabolic process small molecule catabolic process pentose metabolic process pentose catabolic process organic substance catabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR000056	Ribulose-phosphate 3-epimerase-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR011060	Ribulose-phosphate binding barrel	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR026019	Ribulose-phosphate 3-epimerase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.