2FJI

Crystal structure of the C-terminal domain of the exocyst subunit Sec6p

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth 1]	SCOP2 Family	Sec6-like	8047705	4005770	SCOP2 (2022-06-29)
A [auth 1]	SCOP2 Superfamily	Cullin repeat-like	8052698	3000059	SCOP2 (2022-06-29)
B [auth 2]	SCOP2B Superfamily	Cullin repeat-like	8052698	3000059	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth 1]	PF06046	e2fji11	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF06046	ECOD (1.6)
B [auth 2]	PF06046	e2fji21	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF06046	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth 1]	1.10.357.50	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
A [auth 1]	1.10.357.70	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
B [auth 2]	1.10.357.50	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
B [auth 2]	1.10.357.70	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 1], B [auth 2]	PF06046	Exocyst complex component Sec6 (Sec6)	Exocyst complex component Sec6	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 1], B [auth 2]	Exocyst complex component SEC6	protein binding binding SNARE binding	Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization cellular process Golgi vesicle transport protein localization establishment of protein localization nitrogen compound transport Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization cellular process Golgi vesicle transport protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization exocyst localization protein-containing complex localization regulation of localization regulation of cellular process regulation of cellular component organization membrane fusion organelle membrane fusion negative regulation of biological process regulation of vesicle fusion negative regulation of vesicle fusion negative regulation of transport cellular component organization cellular component biogenesis vesicle organization regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly negative regulation of cellular process SNARE complex assembly cellular component organization or biogenesis negative regulation of SNARE complex assembly membrane organization regulation of biological process negative regulation of cellular component organization protein-containing complex organization regulation of transport biological regulation regulation of cellular component biogenesis regulation of vesicle-mediated transport regulation of organelle organization negative regulation of protein-containing complex assembly organelle fusion organelle organization regulation of SNARE complex assembly negative regulation of organelle organization vesicle fusion secretion export from cell membrane docking organelle localization by membrane tethering secretion by cell exocytosis organelle localization vesicle docking exocytic process vesicle docking involved in exocytosis	cellular bud cellular anatomical entity cellular bud tip site of polarized growth cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection ascospore-type prospore membrane prospore membrane intracellular immature spore cellular bud cellular anatomical entity cellular bud tip site of polarized growth cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection ascospore-type prospore membrane prospore membrane intracellular immature spore cellular bud neck cell periphery protein-containing complex cell cortex intracellular anatomical structure exocyst cytoplasm vesicle tethering complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 1], B [auth 2]	IPR010326	Exocyst complex component EXOC3/Sec6	Family
A [auth 1], B [auth 2]	IPR042532	Exocyst complex component EXOC3/Sec6, C-terminal domain	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.