2FDO

Crystal Structure of the Conserved Protein of Unknown Function AF2331 from Archaeoglobus fulgidus DSM 4304 Reveals a New Type of Alpha/Beta Fold

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d2fdoa1	Alpha and beta proteins (a+b)	AF2331-like	AF2331-like	AF2331-like	Hypothetical protein AF2331	(Archaeoglobus fulgidus DSM 4304 ) [TaxId: 224325 ],	SCOPe (2.08)
B [auth A]	d2fdoa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Archaeoglobus fulgidus DSM 4304 ) [TaxId: 224325 ],	SCOPe (2.08)
A [auth B]	d2fdob2	Alpha and beta proteins (a+b)	AF2331-like	AF2331-like	AF2331-like	Hypothetical protein AF2331	(Archaeoglobus fulgidus DSM 4304 ) [TaxId: 224325 ],	SCOPe (2.08)
A [auth B]	d2fdob3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Archaeoglobus fulgidus DSM 4304 ) [TaxId: 224325 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2 Family	AF2331-like	8028416	4000473	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	AF2331-like	8040795	3000372	SCOP2 (2022-06-29)
A [auth B]	SCOP2B Superfamily	AF2331-like	8040795	3000372	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	UNK_F_TYPE	e2fdoA1	A: a+b duplicates or obligate multimers	X: AF2331-like (From Topology)	H: AF2331-like (From Topology)	T: AF2331-like	F: UNK_F_TYPE	ECOD (1.6)
A [auth B]	UNK_F_TYPE	e2fdoB1	A: a+b duplicates or obligate multimers	X: AF2331-like (From Topology)	H: AF2331-like (From Topology)	T: AF2331-like	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	3.30.1970.10	Alpha Beta	2-Layer Sandwich	AF2331-like fold	AF2331-like	CATH (4.3.0)
A [auth B]	3.30.1970.10	Alpha Beta	2-Layer Sandwich	AF2331-like fold	AF2331-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF14556	AF2331-like protein (AF2331-like)	AF2331-like protein	AF2331-like is a 11-kDa orphan protein of unknown function from Archaeoglobus fulgidus. The structure consists of an alpha + beta fold formed by an unusual homodimer, where the two core beta-sheets are interdigitated, containing strands alternating f ...	AF2331-like is a 11-kDa orphan protein of unknown function from Archaeoglobus fulgidus. The structure consists of an alpha + beta fold formed by an unusual homodimer, where the two core beta-sheets are interdigitated, containing strands alternating from both subunits. AF2331 contains multiple negatively charged surface clusters and is located on the same operon as the basic protein AF2330. It is suggested that AF2331 and AF2330 may form a charge-stabilized complex in vivo, though the role of the negatively charged surface clusters is not clear.	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR028986	AF2331-like domain	Domain
A [auth B], B [auth A]	IPR036842	AF2331-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.