Annotations: 2EZ5

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth W]	SCOP2 Family	WW domain	8067155	4002695	SCOP2 (2022-06-29)
A [auth W]	SCOP2 Superfamily	WW domain	8067156	3001621	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth W]	PF00397	e2ez5W1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: PF00397	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth W]	2.20.70.10	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth W]	PF00397	WW domain (WW)	WW domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	Domain
B [auth P]	PF15957	Commissureless (Comm)	Commissureless	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth W]	E3 ubiquitin-protein ligase NEDD4	molecular function inhibitor activity sodium channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity sodium channel regulator activity transporter regulator activity channel inhibitor activity protein binding binding protein domain specific binding signaling receptor binding molecular function inhibitor activity sodium channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity sodium channel regulator activity transporter regulator activity channel inhibitor activity protein binding binding protein domain specific binding signaling receptor binding Notch binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cytoskeletal protein binding myosin binding	neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cell recognition cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon midline choice point recognition axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular process positive regulation of nervous system development positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component biogenesis cellular component assembly cell junction assembly regulation of multicellular organismal process regulation of synapse structure or activity synapse organization regulation of synapse assembly regulation of biological quality positive regulation of cellular process regulation of multicellular organismal development regulation of biological process positive regulation of cellular component biogenesis biological regulation regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly localization import into cell receptor internalization transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport regulation of localization regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport neuromuscular junction development catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of cardioblast proliferation positive regulation of cell population proliferation positive regulation of cell proliferation involved in heart morphogenesis heart morphogenesis cardioblast proliferation regulation of cardioblast proliferation animal organ morphogenesis animal organ formation heart development cell population proliferation heart formation animal organ development circulatory system development cell proliferation involved in heart morphogenesis regulation of cell population proliferation anatomical structure formation involved in morphogenesis regulation of cell proliferation involved in heart morphogenesis cellular response to stimulus response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of smoothened signaling pathway negative regulation of cellular process signal transduction regulation of smoothened signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction smoothened signaling pathway regulation of response to stimulus regulation of cell communication Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process positive regulation of organelle organization regulation of cell differentiation muscle cell differentiation regulation of cell development muscle structure development cellular anatomical entity morphogenesis actin filament-based process cardiac cell development muscle tissue development regulation of cardiac myofibril assembly actomyosin structure organization positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization tissue development regulation of organelle organization myofibril assembly regulation of organelle assembly regulation of supramolecular fiber organization positive regulation of cardiac myofibril assembly striated muscle cell differentiation supramolecular fiber organization positive regulation of organelle assembly regulation of cytoskeleton organization regulation of actin filament-based process cardiac muscle cell development cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly striated muscle tissue development striated muscle cell development muscle cell development organelle assembly actin cytoskeleton organization cardiac muscle tissue development cardiac muscle cell differentiation cardiocyte differentiation organelle organization cardiac myofibril assembly regulation of actomyosin structure organization regulation of actin cytoskeleton organization cytoskeleton organization regulation of neuron projection development dendrite development regulation of dendrite morphogenesis regulation of anatomical structure morphogenesis regulation of cell projection organization dendrite morphogenesis regulation of dendrite development regulation of plasma membrane bounded cell projection organization imaginal disc morphogenesis imaginal disc-derived wing morphogenesis metamorphosis wing disc morphogenesis imaginal disc development instar larval or pupal morphogenesis post-embryonic animal morphogenesis post-embryonic development imaginal disc-derived wing vein morphogenesis appendage development post-embryonic appendage morphogenesis wing disc development instar larval or pupal development imaginal disc-derived appendage morphogenesis appendage morphogenesis imaginal disc-derived appendage development	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm membrane-bounded organelle axon synapse neuron projection axon terminus intracellular membrane-bounded organelle subsynaptic reticulum plasma membrane bounded cell projection cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm membrane-bounded organelle axon synapse neuron projection axon terminus intracellular membrane-bounded organelle subsynaptic reticulum plasma membrane bounded cell projection intracellular organelle presynapse cell projection distal axon terminal bouton organelle cell junction neuron projection terminus type I terminal bouton
B [auth P]	Commissureless LPSY Peptide	protein binding binding signaling receptor binding Roundabout binding WW domain binding protein domain specific binding molecular sequestering activity protein sequestering activity	multicellular organismal process dendrite guidance cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development multicellular organismal process dendrite guidance cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular process neuron recognition axonogenesis axon choice point recognition cell recognition axon midline choice point recognition axon guidance axon development localization import into cell receptor internalization transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport regulation of localization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process regulation of receptor internalization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis positive regulation of cellular process regulation of endocytosis regulation of biological process regulation of transport regulation of receptor-mediated endocytosis biological regulation regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport regulation of neuron projection development regulation of developmental process regulation of cell projection organization regulation of dendrite development regulation of plasma membrane bounded cell projection organization cellular localization post-Golgi vesicle-mediated transport intracellular transport lysosomal transport Golgi to vacuole transport cytosolic transport establishment of localization in cell vacuolar transport Golgi to lysosome transport Golgi vesicle transport cellular component biogenesis cell junction organization cellular component assembly cell junction assembly synapse organization synapse assembly	membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle endocytic vesicle endosome membrane endosome late endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane late endosome organelle membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth W]	IPR035983	HECT, E3 ligase catalytic domain	Homologous Superfamily
A [auth W]	IPR036020	WW domain superfamily	Homologous Superfamily
A [auth W]	IPR000008	C2 domain	Domain
A [auth W]	IPR000569	HECT domain	Domain
A [auth W]	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type	Family
A [auth W]	IPR035892	C2 domain superfamily	Homologous Superfamily
A [auth W]	IPR001202	WW domain	Domain
B [auth P]	IPR031878	Commissureless	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.