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2ENM
Solution structure of the SH3 domain from mouse sorting nexin-9
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Domain Annotation: SCOP/SCOPe Classification
SCOP-e Database Homepage
Chains
Domain Info
Class
Fold
Superfamily
Family
Domain
Species
Provenance Source (Version)
A
d2enma1
All beta proteins
SH3-like barrel
SH3-domain
automated matches
automated matches
house mouse
(
Mus musculus
) [TaxId:
10090
],
SCOPe (2.08)
A
d2enma2
Artifacts
Tags
Tags
Tags
N-terminal Tags
house mouse
(
Mus musculus
) [TaxId:
10090
],
SCOPe (2.08)
Domain Annotation: SCOP2 Classification
SCOP2 Database Homepage
Chains
Type
Family Name
Domain Identifier
Family Identifier
Provenance Source (Version)
A
SCOP2 Family
SH3-domain
8065214
4000369
SCOP2 (2022-06-29)
A
SCOP2 Superfamily
SH3-domain
8065215
3000153
SCOP2 (2022-06-29)
Domain Annotation: ECOD Classification
ECOD Database Homepage
Chains
Family Name
Domain Identifier
Architecture
Possible Homology
Homology
Topology
Family
Provenance Source (Version)
A
PF00018
e2enmA1
A: beta barrels
X: SH3
H: SH3
T: SH3
F: PF00018
ECOD (1.6)
Domain Annotation: CATH
CATH Database Homepage
Chain
Domain
Class
Architecture
Topology
Homology
Provenance Source (Version)
A
2.30.30.40
Mainly Beta
Roll
SH3 type barrels.
SH3 Domains
CATH (4.3.0)
Protein Family Annotation
Pfam Database Homepage
Chains
Accession
Name
Description
Comments
Source
A
PF00018
SH3 domain (SH3_1)
SH3 domain
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.
Domain
Gene Ontology: Gene Product Annotation
Gene Ontology Database Homepage
Chains
Polymer
Molecular Function
Biological Process
Cellular Component
A
Sorting nexin-9
binding
phospholipid binding
lipid binding
phosphatidylinositol binding
identical protein binding
protein binding
protein homodimerization activity
protein dimerization activity
1-phosphatidylinositol binding
ubiquitin protein ligase binding
ubiquitin-like protein ligase binding
enzyme binding
protein-containing complex binding
Arp2/3 complex binding
cellular component organization
cellular component biogenesis
cellular component assembly
protein-containing complex organization
protein-containing complex assembly
cellular process
cellular component organization or biogenesis
membrane organization
cytoskeleton-dependent cytokinesis
cytokinesis
cleavage furrow formation
cytokinetic process
membrane invagination
cell cycle
cellular component organization
cellular component biogenesis
cellular component assembly
protein-containing complex organization
protein-containing complex assembly
cellular process
cellular component organization or biogenesis
membrane organization
cytoskeleton-dependent cytokinesis
cytokinesis
cleavage furrow formation
cytokinetic process
membrane invagination
cell cycle
cell division
plasma membrane invagination
cell cycle process
mitotic cell cycle process
mitotic cytokinesis
mitotic cell cycle
localization
import into cell
transport
endocytosis
establishment of localization
vesicle-mediated transport
positive regulation of molecular function
regulation of molecular function
positive regulation of hydrolase activity
regulation of catalytic activity
regulation of hydrolase activity
biological regulation
positive regulation of catalytic activity
regulation of GTPase activity
positive regulation of GTPase activity
regulation of localization
cellular localization
regulation of cellular process
regulation of cellular component organization
synaptic vesicle cycle
regulation of synaptic vesicle recycling
presynaptic endocytosis
vesicle-mediated transport in synapse
synaptic vesicle recycling
regulation of synaptic vesicle endocytosis
establishment of localization in cell
regulation of endocytosis
synaptic vesicle endocytosis
regulation of biological process
regulation of transport
regulation of vesicle-mediated transport
plasma membrane tubulation
plasma membrane organization
endomembrane system organization
protein localization
establishment of protein localization
nitrogen compound transport
organic substance transport
intracellular transport
protein transport
cellular macromolecule localization
macromolecule localization
intracellular protein transport
endosomal transport
positive regulation of organelle organization
regulation of cytoskeleton organization
positive regulation of cellular component organization
regulation of actin filament-based process
regulation of cellular component size
positive regulation of biological process
regulation of protein-containing complex assembly
positive regulation of protein-containing complex assembly
positive regulation of protein polymerization
actin filament-based process
regulation of actin filament polymerization
regulation of biological quality
positive regulation of cellular process
protein polymerization
actin polymerization or depolymerization
regulation of actin filament organization
actin filament polymerization
actin cytoskeleton organization
positive regulation of cellular component biogenesis
positive regulation of cytoskeleton organization
actin filament organization
regulation of actin polymerization or depolymerization
positive regulation of supramolecular fiber organization
regulation of cellular component biogenesis
regulation of organelle organization
organelle organization
regulation of protein polymerization
regulation of actin filament length
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
supramolecular fiber organization
positive regulation of actin filament polymerization
cytoskeleton organization
regulation of anatomical structure size
lipid tube assembly
protein-lipid complex organization
protein-lipid complex assembly
catabolic process
positive regulation of protein metabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of cellular metabolic process
macromolecule catabolic process
regulation of primary metabolic process
cellular catabolic process
positive regulation of metabolic process
organic substance metabolic process
regulation of proteolysis
proteolysis
membrane protein proteolysis
positive regulation of macromolecule metabolic process
protein metabolic process
membrane protein ectodomain proteolysis
organonitrogen compound catabolic process
regulation of membrane protein ectodomain proteolysis
organonitrogen compound metabolic process
cellular metabolic process
regulation of protein metabolic process
primary metabolic process
regulation of cellular metabolic process
regulation of catabolic process
regulation of macromolecule metabolic process
protein catabolic process
positive regulation of protein catabolic process
positive regulation of catabolic process
positive regulation of proteolysis
regulation of cellular catabolic process
positive regulation of cellular catabolic process
metabolic process
macromolecule metabolic process
regulation of metabolic process
organic substance catabolic process
regulation of protein catabolic process
receptor-mediated endocytosis
Less
clathrin-coated pit
membrane
cellular anatomical entity
endomembrane system
membrane-bounded organelle
intracellular anatomical structure
intracellular vesicle
intracellular membrane-bounded organelle
intracellular organelle
cytoplasmic vesicle
organelle
clathrin-coated vesicle
coated vesicle
cytoplasm
clathrin-coated pit
membrane
cellular anatomical entity
endomembrane system
membrane-bounded organelle
intracellular anatomical structure
intracellular vesicle
intracellular membrane-bounded organelle
intracellular organelle
cytoplasmic vesicle
organelle
clathrin-coated vesicle
coated vesicle
cytoplasm
vesicle
cytosol
cell periphery
plasma membrane
presynapse
synapse
cell junction
cytoplasmic vesicle membrane
vesicle membrane
organelle membrane
Golgi apparatus subcompartment
Golgi apparatus
organelle subcompartment
trans-Golgi network
ruffle
cell projection
cell leading edge
plasma membrane bounded cell projection
Less
InterPro: Protein Family Classification
InterPro Database Homepage
Chains
Accession
Name
Type
A
IPR001683
Phox homology
Domain
A
IPR036028
SH3-like domain superfamily
Homologous Superfamily
A
IPR027267
AH/BAR domain superfamily
Homologous Superfamily
A
IPR014536
Sorting nexin 9 family
Family
A
IPR019497
Sorting nexin protein, WASP-binding domain
Domain
A
IPR035558
SNX9, SH3 domain
Domain
A
IPR037425
Sorting nexin-9, BAR domain
Domain
A
IPR037426
Sorting nexin-9, PX domain
Domain
A
IPR036871
PX domain superfamily
Homologous Superfamily
A
IPR001452
SH3 domain
Domain
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