2EJN

Structural characterization of the tetrameric form of the major cat allergen fel D 1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ejna1	All alpha proteins	Uteroglobin-like	Uteroglobin-like	Uteroglobin-like	Allergen Fel d I-A chain	domestic cat (Felis catus ) [TaxId: 9685 ], domestic cat (Felis catus ) [TaxId: 9685 ],	SCOPe (2.08)
A	d2ejna2	All alpha proteins	Uteroglobin-like	Uteroglobin-like	Uteroglobin-like	Allergen Fel d I-B chain	domestic cat (Felis catus ) [TaxId: 9685 ], domestic cat (Felis catus ) [TaxId: 9685 ],	SCOPe (2.08)
B	d2ejnb1	All alpha proteins	Uteroglobin-like	Uteroglobin-like	Uteroglobin-like	Allergen Fel d I-A chain	domestic cat (Felis catus ) [TaxId: 9685 ], domestic cat (Felis catus ) [TaxId: 9685 ],	SCOPe (2.08)
B	d2ejnb2	All alpha proteins	Uteroglobin-like	Uteroglobin-like	Uteroglobin-like	Allergen Fel d I-B chain	domestic cat (Felis catus ) [TaxId: 9685 ], domestic cat (Felis catus ) [TaxId: 9685 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Uteroglobin-like	8027741	4001162	SCOP2 (2022-06-29)
A	SCOP2 Family	Uteroglobin-like	8027742	4001162	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Uteroglobin-like	8040120	3000959	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Uteroglobin-like	8040121	3000959	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Uteroglobin-like	8040121	3000959	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01099	e2ejnA1	A: alpha arrays	X: Uteroglobin-like (From Topology)	H: Uteroglobin-like (From Topology)	T: Uteroglobin-like	F: PF01099	ECOD (1.6)
A	PF09252	e2ejnA2	A: alpha arrays	X: Uteroglobin-like (From Topology)	H: Uteroglobin-like (From Topology)	T: Uteroglobin-like	F: PF09252	ECOD (1.6)
B	PF01099	e2ejnB1	A: alpha arrays	X: Uteroglobin-like (From Topology)	H: Uteroglobin-like (From Topology)	T: Uteroglobin-like	F: PF01099	ECOD (1.6)
B	PF09252	e2ejnB2	A: alpha arrays	X: Uteroglobin-like (From Topology)	H: Uteroglobin-like (From Topology)	T: Uteroglobin-like	F: PF09252	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.920.50	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
B	1.20.920.50	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09252	Allergen Fel d I-B chain (Feld-I_B)	Allergen Fel d I-B chain	Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide [1].	Domain
A, B	PF01099	Uteroglobin family (Uteroglobin)	Uteroglobin family	Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Major allergen I polypeptide chain 1, chain 2	binding organic cyclic compound binding steroid binding lipid binding	-	extracellular region cellular anatomical entity extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006178	Major allergen I polypeptide chain 1	Family
A, B	IPR016126	Secretoglobin	Family
A, B	IPR035960	Secretoglobin superfamily	Homologous Superfamily
A, B	IPR016126	Secretoglobin	Family
A, B	IPR035960	Secretoglobin superfamily	Homologous Superfamily
A, B	IPR015332	Major allergen I polypeptide chain 2-like	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.