2EHO

Crystal structure of human GINS complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2ehoa1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	SLD5 N-terminal domain-like	GINS complex subunit 4, SLD5	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2ehoe1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	SLD5 N-terminal domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d2ehoe2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d2ehoi1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	SLD5 N-terminal domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d2ehoi2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2ehob1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF1 N-terminal domain-like	DNA replication complex GINS protein PSF1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2ehof2	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF1 N-terminal domain-like	DNA replication complex GINS protein PSF1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d2ehof3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d2ehoj_	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF1 N-terminal domain-like	DNA replication complex GINS protein PSF1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2ehoc1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF2 C-terminal domain-like	DNA replication complex GINS protein PSF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2ehoc2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	PSF2 N-terminal domain-like	DNA replication complex GINS protein PSF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d2ehoc3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2ehog1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF2 C-terminal domain-like	DNA replication complex GINS protein PSF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2ehog2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d2ehog3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d2ehok1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF2 C-terminal domain-like	DNA replication complex GINS protein PSF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d2ehok2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d2ehok3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2ehod1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF3 C-terminal domain-like	GINS complex subunit 3, PSF3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d2ehod2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	PSF3 N-terminal domain-like	GINS complex subunit 3, PSF3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2ehoh1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF3 C-terminal domain-like	GINS complex subunit 3, PSF3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d2ehoh2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	PSF3 N-terminal domain-like	GINS complex subunit 3, PSF3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d2ehol1	All alpha proteins	GINS helical bundle-like	GINS helical bundle-like	PSF3 C-terminal domain-like	GINS complex subunit 3, PSF3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d2ehol2	Alpha and beta proteins (a+b)	GINS/PriA/YqbF domain	PriA/YqbF domain	PSF3 N-terminal domain-like	GINS complex subunit 3, PSF3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GINS helical bundle-like	8033896	3001594	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GINS helical bundle-like	8033896	3001594	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PriA/YqbF domain	8033897	3000274	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	GINS helical bundle-like	8033896	3001594	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PriA/YqbF domain	8033897	3000274	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GINS helical bundle-like	8033891	3001594	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GINS helical bundle-like	8033891	3001594	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	GINS helical bundle-like	8033891	3001594	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GINS helical bundle-like	8033892	3001594	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PriA/YqbF domain	8033893	3000274	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PriA/YqbF domain	8033893	3000274	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GINS helical bundle-like	8033892	3001594	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PriA/YqbF domain	8033893	3000274	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	GINS helical bundle-like	8033892	3001594	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PriA/YqbF domain	8035319	3000274	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GINS helical bundle-like	8035318	3001594	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PriA/YqbF domain	8035319	3000274	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GINS helical bundle-like	8035318	3001594	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	PriA/YqbF domain	8035319	3000274	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	GINS helical bundle-like	8035318	3001594	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05916	e2ehoA1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
E	PF05916	e2ehoE1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
E	PF16922	e2ehoE2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF16922	ECOD (1.6)
I	PF05916	e2ehoI1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
I	PF16922	e2ehoI2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF16922	ECOD (1.6)
B	PF05916	e2ehoB1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
F	PF05916	e2ehoF1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
J	PF05916	e2ehoJ1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
C	PF05916	e2ehoC1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
C	F_UNCLASSIFIED	e2ehoC2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF05916	e2ehoG1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
G	F_UNCLASSIFIED	e2ehoG2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: F_UNCLASSIFIED	ECOD (1.6)
K	PF05916	e2ehoK1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
K	F_UNCLASSIFIED	e2ehoK2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF05916	e2ehoD1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
D	PF22466	e2ehoD2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF22466	ECOD (1.6)
H	PF05916	e2ehoH1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
H	PF22466	e2ehoH2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF22466	ECOD (1.6)
L	PF05916	e2ehoL1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
L	PF22466	e2ehoL2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF22466	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.1030	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E	1.20.58.1030	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E	3.40.5.60	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)
I	1.20.58.1030	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
I	3.40.5.60	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)
B	1.20.58.1030	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
F	1.20.58.1030	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
J	1.20.58.1030	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	3.40.5.50	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)
C	1.20.58.1020	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
G	3.40.5.50	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)
G	1.20.58.1020	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
K	3.40.5.50	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)
K	1.20.58.1020	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.20.58.2050	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
H	1.20.58.2050	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
L	1.20.58.2050	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E, I	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family
A, E, I	PF16922	DNA replication complex GINS protein SLD5 C-terminus (SLD5_C)	DNA replication complex GINS protein SLD5 C-terminus	The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks [1].	Domain
B, F, J	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family
C, G, K	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family
D, H, L	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E, I	GINS complex subunit 4	-	DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair developmental process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex cytoplasm
B, F, J	DNA replication complex GINS protein PSF1	-	mitotic DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle nucleobase-containing compound metabolic process DNA strand elongation organic substance metabolic process DNA strand elongation involved in cell cycle DNA replication cell cycle cell cycle process DNA-templated DNA replication primary metabolic process DNA metabolic process mitotic DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle nucleobase-containing compound metabolic process DNA strand elongation organic substance metabolic process DNA strand elongation involved in cell cycle DNA replication cell cycle cell cycle process DNA-templated DNA replication primary metabolic process DNA metabolic process DNA strand elongation involved in nuclear cell cycle DNA replication nucleic acid metabolic process organic cyclic compound metabolic process DNA replication mitotic cell cycle process metabolic process cellular process macromolecule metabolic process DNA strand elongation involved in DNA replication DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis developmental process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex cytoplasm
C, G, K	DNA replication complex GINS protein PSF2	-	DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex
D, H, L	GINS complex subunit 3	-	mitotic DNA replication DNA-templated DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process mitotic DNA replication initiation nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process organic cyclic compound metabolic process nuclear cell cycle DNA replication initiation DNA replication mitotic DNA replication DNA-templated DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process mitotic DNA replication initiation nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process organic cyclic compound metabolic process nuclear cell cycle DNA replication initiation DNA replication organic substance metabolic process mitotic cell cycle process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E, I	IPR008591	GINS complex subunit Sld5	Family
A, E, I	IPR038749	GINS complex protein Sld5, alpha-helical domain	Domain
A, E, I	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
A, E, I	IPR021151	GINS subunit, domain A	Domain
A, E, I	IPR031633	DNA replication complex GINS protein SLD5, C-terminal	Domain
B, F, J	IPR021151	GINS subunit, domain A	Domain
B, F, J	IPR005339	GINS complex, subunit Psf1	Family
B, F, J	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
C, G, K	IPR007257	DNA replication complex GINS protein Psf2	Family
C, G, K	IPR021151	GINS subunit, domain A	Domain
C, G, K	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
D, H, L	IPR021151	GINS subunit, domain A	Domain
D, H, L	IPR010492	GINS complex, subunit Psf3	Family
D, H, L	IPR038437	GINS complex, subunit Psf3 superfamily	Homologous Superfamily
D, H, L	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E, I	Pharos: Q9BRT9	large cell medulloblastoma non-small cell lung carcinoma psoriasis malignant mesothelioma osteosarcoma medulloblastoma ovarian cancer
B, F, J	Pharos: Q14691	malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor adrenal cortex carcinoma atypical teratoid rhabdoid tumor combined immunodeficiency due to GINS1 deficiency esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor adrenal cortex carcinoma atypical teratoid rhabdoid tumor combined immunodeficiency due to GINS1 deficiency esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema breast cancer ductal breast carcinoma in situ exocrine pancreatic carcinoma IgA glomerulonephritis lung adenocarcinoma malignant mesothelioma nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pituitary cancer attention deficit hyperactivity disorder, inattentive type breast carcinoma endometriosis glioblastoma invasive ductal breast carcinoma lung cancer
C, G, K	Pharos: Q9Y248	salivary gland adenoid cystic carcinoma adenoid cystic carcinoma ovarian cancer pituitary cancer acute myeloid leukemia atypical teratoid rhabdoid tumor ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor salivary gland cancer breast cancer salivary gland adenoid cystic carcinoma adenoid cystic carcinoma ovarian cancer pituitary cancer acute myeloid leukemia atypical teratoid rhabdoid tumor ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor salivary gland cancer breast cancer endometriosis large cell medulloblastoma lung carcinoma Malignant neoplasm of salivary gland osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis adrenal cortex carcinoma breast carcinoma glioblastoma lung adenocarcinoma malignant ependymoma medulloblastoma
D, H, L	Pharos: Q9BRX5	adrenal cortex carcinoma atypical teratoid rhabdoid tumor lung cancer medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor glioblastoma malignant ependymoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema large cell medulloblastoma malignant glioma adrenal cortex carcinoma atypical teratoid rhabdoid tumor lung cancer medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor glioblastoma malignant ependymoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema large cell medulloblastoma malignant glioma non-small cell lung carcinoma primary biliary cholangitis