2E9H

Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01873	e2e9hA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01873	ECOD (1.6)
A	F_UNCLASSIFIED	e2e9hA1	A: few secondary structure elements	X: Rubredoxin-like	H: Zinc-binding domain of translation initiation factor 2 beta (From Topology)	T: Zinc-binding domain of translation initiation factor 2 beta	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.30.170	Alpha Beta	2-Layer Sandwich	Defensin A-like		CATH (4.3.0)
A	2.20.25.350	Mainly Beta	Single Sheet	N-terminal domain of TfIIb		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01873	Domain found in IF2B/IF5 (eIF-5_eIF-2B)	Domain found in IF2B/IF5	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Eukaryotic translation initiation factor 5	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding eukaryotic initiation factor eIF2 binding translation initiation factor binding cell adhesion molecule binding cadherin binding GTPase regulator activity enzyme regulator activity translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding eukaryotic initiation factor eIF2 binding translation initiation factor binding cell adhesion molecule binding cadherin binding GTPase regulator activity enzyme regulator activity GDP-dissociation inhibitor activity nucleoside-triphosphatase regulator activity molecular function regulator activity enzyme activator activity GTPase activator activity molecular function activator activity RNA binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process translational initiation protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of translational initiation cellular metabolic process regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process translational initiation protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process regulation of translational initiation cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis formation of translation preinitiation complex protein-containing complex organization cytoplasmic translation cytoplasmic translational initiation formation of cytoplasmic translation initiation complex organelle assembly non-membrane-bounded organelle assembly ribosome biogenesis organelle organization ribosome assembly	synapse cell junction cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016190	Translation initiation factor IF2/IF5, zinc-binding	Homologous Superfamily
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR016189	Translation initiation factor IF2/IF5, N-terminal	Homologous Superfamily
A	IPR003307	W2 domain	Domain
A	IPR002735	Translation initiation factor IF2/IF5 domain	Domain
A	IPR045196	Translation initiation factor IF2/IF5	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P55010	schizophrenia tuberculosis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant colon neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma psoriasis breast cancer heart disease lung adenocarcinoma malignant glioma osteosarcoma Pick disease schizophrenia tuberculosis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant colon neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma psoriasis breast cancer heart disease lung adenocarcinoma malignant glioma osteosarcoma Pick disease dermatomyositis hereditary spastic paraplegia lung cancer Malignant neoplasm of breast ovarian cancer pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.