2E19

Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00046	e2e19A1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00046	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transcription factor 8	DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding E-box binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process pattern specification process cellular developmental process cell differentiation cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to endogenous stimulus response to growth factor cellular response to stimulus cell surface receptor protein serine/threonine kinase signaling pathway signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway cell population proliferation regulation of cell population proliferation mesenchymal cell proliferation regulation of mesenchymal cell proliferation response to activity epithelial cell proliferation keratinocyte proliferation smooth muscle cell differentiation regulation of developmental process regulation of smooth muscle cell differentiation regulation of cell differentiation muscle cell differentiation muscle structure development regulation of muscle cell differentiation embryonic organ morphogenesis chordate embryonic development embryonic morphogenesis embryo development anatomical structure morphogenesis embryo development ending in birth or egg hatching animal organ morphogenesis embryonic skeletal system development skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis head development forebrain development brain development nervous system development central nervous system development positive regulation of biological process positive regulation of neuron differentiation positive regulation of developmental process neurogenesis neuron differentiation positive regulation of cell differentiation positive regulation of cellular process generation of neurons regulation of neuron differentiation ear morphogenesis ear development sensory organ development sensory organ morphogenesis inner ear development cochlea development inner ear morphogenesis cochlea morphogenesis tube development semicircular canal morphogenesis tube morphogenesis semicircular canal development cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to organic substance cellular response to chemical stimulus response to chemical response to amino acid regulation of leukocyte differentiation regulation of leukocyte activation cell development regulation of cell activation regulation of T cell differentiation in thymus mononuclear cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation T cell differentiation in thymus T cell activation T cell differentiation regulation of immune system process regulation of multicellular organismal process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis cell activation regulation of T cell activation immune system process regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation endothelium development epithelial cell differentiation regulation of epithelial cell differentiation negative regulation of cell differentiation epithelium development negative regulation of epithelial cell differentiation endothelial cell differentiation negative regulation of developmental process regulation of endothelial cell differentiation negative regulation of endothelial cell differentiation negative regulation of cell population proliferation regulation of keratinocyte proliferation negative regulation of keratinocyte proliferation regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation embryonic eye morphogenesis visual system development embryonic camera-type eye development eye morphogenesis sensory system development camera-type eye morphogenesis eye development embryonic camera-type eye morphogenesis camera-type eye development transcription by RNA polymerase II regulation of transcription by RNA polymerase II response to nutrient levels negative regulation of transcription by RNA polymerase II positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001356	Homeobox domain	Domain
A	IPR013087	Zinc finger C2H2-type	Domain
A	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
A	IPR008598	Drought induced 19 protein type, zinc-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P37275	corneal dystrophy, Fuchs endothelial, 6 posterior polymorphous corneal dystrophy 3 Fuchs' endothelial dystrophy ovarian cancer primary cutaneous T-cell non-Hodgkin lymphoma breast cancer oral submucous fibrosis Sezary syndrome breast carcinoma Neoplasm Invasiveness endometrial carcinoma familial nonmedullary thyroid carcinoma Gaucher disease pancreatic intraductal papillary-mucinous carcinoma hereditary spastic paraplegia corneal dystrophy, Fuchs endothelial, 6 posterior polymorphous corneal dystrophy 3 Fuchs' endothelial dystrophy ovarian cancer primary cutaneous T-cell non-Hodgkin lymphoma breast cancer oral submucous fibrosis Sezary syndrome breast carcinoma Neoplasm Invasiveness endometrial carcinoma familial nonmedullary thyroid carcinoma Gaucher disease pancreatic intraductal papillary-mucinous carcinoma hereditary spastic paraplegia pilocytic astrocytoma juvenile dermatomyositis lung adenocarcinoma psoriasis stomach disease malignant glioma thyroid gland papillary carcinoma cancer malignant pancreatic neoplasm medulloblastoma Emery-Dreifuss muscular dystrophy ovarian neoplasm glioblastoma pancreatic intraductal papillary-mucinous neoplasm intestinal disease keratoconus primitive neuroectodermal tumor lung cancer adenoma malignant colon neoplasm subependymal giant cell astrocytoma tuberculosis coronary artery disease myocardial ischemia endometrial cancer non-small cell lung carcinoma osteosarcoma gastric carcinoma pancreatic ductal adenocarcinoma granulomatous slack skin disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia invasive ductal breast carcinoma large cell medulloblastoma prostate disease lung disease Sjogren syndrome astrocytic tumor malignant ependymoma breast disease ulcerative colitis corneal dystrophy cystic fibrosis ductal breast carcinoma in situ oligodendroglioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.