2DSR

Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth G]	d2dsrg1	Small proteins	Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	Thyroglobulin type-1 domain	Insulin-like growth factor-binding protein 4, IGFBP4	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2dsrb_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	Growth factor receptor domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth I]	d2dsri_	Small proteins	Insulin-like	Insulin-like	Insulin-like	Insulin-like growth factor	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth G]	SCOP2 Family	Thyroglobulin type-1 domain	8020453	4003524	SCOP2 (2022-06-29)
A [auth G]	SCOP2 Superfamily	Thyroglobulin type-1 domain	8032833	3000991	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Growth factor receptor domain-like	8032824	3000398	SCOP2B (2022-06-29)
C [auth I]	SCOP2B Superfamily	Insulin-like	8033230	3000307	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth G]	PF00086	e2dsrG1	A: few secondary structure elements	X: Thyroglobulin type-1 domain (From Topology)	H: Thyroglobulin type-1 domain (From Topology)	T: Thyroglobulin type-1 domain	F: PF00086	ECOD (1.6)
B	PF00219	e2dsrB1	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: PF00219	ECOD (1.6)
C [auth I]	PF00049	e2dsrI1	A: few secondary structure elements	X: Insulin-like (From Topology)	H: Insulin-like (From Topology)	T: Insulin-like	F: PF00049	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth G]	4.10.800.10	Few Secondary Structures	Irregular	Invariant Chain	Chain I	CATH (4.3.0)
B	4.10.40.20	Few Secondary Structures	Irregular	Omega-AgatoxinV		CATH (4.3.0)
C [auth I]	1.10.100.10	Mainly Alpha	Orthogonal Bundle	Insulin-like, subunit E	Insulin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth G]	PF00086	Thyroglobulin type-1 repeat (Thyroglobulin_1)	Thyroglobulin type-1 repeat	Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation [2]. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.	Domain
B	PF00219	Insulin-like growth factor binding protein (IGFBP)	Insulin-like growth factor binding protein	-	Domain
C [auth I]	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth G]	Insulin-like growth factor-binding protein 4	protein binding binding signaling receptor binding insulin-like growth factor binding insulin-like growth factor II binding growth factor binding insulin-like growth factor I binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway signal transduction cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation insulin-like growth factor receptor signaling pathway regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade cell population proliferation type B pancreatic cell proliferation epithelial cell proliferation negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis response to organic substance response to chemical response to organic cyclic compound monosaccharide metabolic process carbohydrate metabolic process primary metabolic process hexose metabolic process regulation of primary metabolic process organic substance metabolic process regulation of small molecule metabolic process metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process regulation of metabolic process glucose metabolic process	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region extracellular space
B	Insulin-like growth factor-binding protein 4	protein binding binding signaling receptor binding insulin-like growth factor binding insulin-like growth factor II binding growth factor binding insulin-like growth factor I binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway signal transduction cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation insulin-like growth factor receptor signaling pathway regulation of response to stimulus regulation of cell communication cellular process positive regulation of signaling intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade cell population proliferation type B pancreatic cell proliferation epithelial cell proliferation negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis response to organic substance response to chemical response to organic cyclic compound monosaccharide metabolic process carbohydrate metabolic process primary metabolic process hexose metabolic process regulation of primary metabolic process organic substance metabolic process regulation of small molecule metabolic process metabolic process small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process regulation of metabolic process glucose metabolic process	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region extracellular space
C [auth I]	Insulin-like growth factor IB	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity insulin receptor binding insulin-like growth factor receptor binding cell adhesion molecule binding protein-containing complex binding integrin binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity insulin receptor binding insulin-like growth factor receptor binding cell adhesion molecule binding protein-containing complex binding integrin binding hormone activity	regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production organic substance metabolic process cytokine production organic substance biosynthetic process regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of protein stability regulation of biological quality protein stabilization cell activation myoblast proliferation cell population proliferation developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development myoblast differentiation positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of protein modification process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity positive regulation of cellular process organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation multicellular organism development skeletal system development system development positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process myotube cell development cell development muscle cell differentiation myotube differentiation muscle cell development striated muscle cell differentiation animal organ development muscle organ development regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress regulation of neuroinflammatory response negative regulation of defense response inflammatory response negative regulation of neuroinflammatory response neuroinflammatory response positive regulation of transcription regulatory region DNA binding regulation of transcription regulatory region DNA binding cellular response to stimulus cell surface receptor signaling pathway signaling insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion muscle hypertrophy system process muscle system process positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division bone maturation bone mineralization bone mineralization involved in bone maturation developmental maturation tissue development ossification anatomical structure maturation biomineral tissue development ossification involved in bone maturation animal organ maturation bone development positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway regulation of signaling regulation of cell communication positive regulation of signaling negative regulation of signaling apoptotic mitochondrial changes regulation of release of cytochrome c from mitochondria regulation of programmed cell death negative regulation of cell communication negative regulation of release of cytochrome c from mitochondria negative regulation of apoptotic signaling pathway mitochondrion organization negative regulation of cellular component organization negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction apoptotic signaling pathway release of cytochrome c from mitochondria negative regulation of apoptotic process negative regulation of organelle organization regulation of mitochondrion organization apoptotic process programmed cell death regulation of apoptotic signaling pathway mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition amyloid precursor protein catabolic process regulation of amide metabolic process regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process amyloid precursor protein metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amide metabolic process regulation of muscle adaptation positive regulation of cardiac muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of growth regulation of cardiac muscle tissue growth developmental growth regulation of cell differentiation positive regulation of developmental process regulation of organ growth regulation of heart growth cardiac muscle tissue growth muscle tissue development cardiac cell development positive regulation of developmental growth positive regulation of heart growth heart growth positive regulation of organ growth positive regulation of muscle cell differentiation regulation of muscle cell differentiation positive regulation of cardiac muscle tissue growth positive regulation of cell growth involved in cardiac muscle cell development regulation of developmental process cardiac muscle cell development regulation of striated muscle cell differentiation organ growth cell growth striated muscle tissue development positive regulation of cell differentiation positive regulation of striated muscle cell differentiation heart development regulation of multicellular organismal development regulation of developmental growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy growth cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development positive regulation of cell growth regulation of cell growth cardiocyte differentiation circulatory system development cell growth involved in cardiac muscle cell development positive regulation of growth physiological cardiac muscle hypertrophy response to heat response to abiotic stimulus response to temperature stimulus nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process tissue regeneration skeletal muscle tissue regeneration skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration maintenance of cell number regeneration pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process cellular catabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process small molecule metabolic process purine ribonucleotide catabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process positive regulation of carbohydrate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process organic cyclic compound catabolic process purine-containing compound metabolic process positive regulation of catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process pyridine-containing compound metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process nucleotide metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process catabolic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of catabolic process regulation of glycolytic process positive regulation of purine nucleotide metabolic process organophosphate metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of small molecule metabolic process sexual reproduction regulation of reproductive process regulation of oogenesis reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction female gamete generation gamete generation regulation of cell development oocyte development negative regulation of cell differentiation negative regulation of developmental process regulation of oocyte development multicellular organismal reproductive process oogenesis negative regulation of cell development negative regulation of reproductive process negative regulation of oocyte development germ cell development oocyte differentiation intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of glycogen metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of glucose metabolic process polysaccharide biosynthetic process glycogen metabolic process glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process glucose metabolic process fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation vascular associated smooth muscle cell proliferation calcineurin-NFAT signaling cascade regulation of calcineurin-mediated signaling positive regulation of calcineurin-NFAT signaling cascade regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade positive regulation of calcineurin-mediated signaling calcium-mediated signaling calcineurin-mediated signaling positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction organic hydroxy compound metabolic process alcohol metabolic process glycolate metabolic process primary alcohol metabolic process small GTPase-mediated signal transduction Ras protein signal transduction regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion organic substance transport regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization proteoglycan biosynthetic process proteoglycan metabolic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of smooth muscle cell apoptotic process negative regulation of vascular associated smooth muscle cell apoptotic process vascular associated smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process negative regulation of muscle cell apoptotic process regulation of vascular associated smooth muscle cell apoptotic process regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation peptidyl-amino acid modification tyrosine phosphorylation of STAT protein cell surface receptor signaling pathway via STAT peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT chordate embryonic development embryo development trophectodermal cell proliferation embryo development ending in birth or egg hatching in utero embryonic development positive regulation of trophectodermal cell proliferation regulation of trophectodermal cell proliferation blastocyst growth blastocyst development wound healing response to wounding cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to endogenous stimulus response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to organic substance response to amyloid-beta hexose transmembrane transport glucose import carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction positive regulation of small GTPase mediated signal transduction	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex cellular anatomical entity membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm platelet alpha granule vesicle platelet alpha granule lumen extracellular region extracellular space insulin-like growth factor binding protein complex growth factor complex transport vesicle exocytic vesicle insulin-like growth factor ternary complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth G]	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata	Family
A [auth G]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A [auth G]	IPR036857	Thyroglobulin type-1 superfamily	Homologous Superfamily
A [auth G]	IPR022327	Insulin-like growth factor-binding protein 4	Family
A [auth G]	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site	Conserved Site
A [auth G]	IPR000716	Thyroglobulin type-1	Domain
A [auth G]	IPR000867	Insulin-like growth factor-binding protein, IGFBP	Domain
B	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata	Family
B	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
B	IPR036857	Thyroglobulin type-1 superfamily	Homologous Superfamily
B	IPR022327	Insulin-like growth factor-binding protein 4	Family
B	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site	Conserved Site
B	IPR000716	Thyroglobulin type-1	Domain
B	IPR000867	Insulin-like growth factor-binding protein, IGFBP	Domain
C [auth I]	IPR022350	Insulin-like growth factor	Family
C [auth I]	IPR022353	Insulin, conserved site	Conserved Site
C [auth I]	IPR036438	Insulin-like superfamily	Homologous Superfamily
C [auth I]	IPR022352	Insulin family	Family
C [auth I]	IPR016179	Insulin-like	Domain
C [auth I]	IPR022341	Insulin-like growth factor I	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth G]	Pharos: P22692	malignant pancreatic neoplasm myopathy pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor adrenal cortex carcinoma Becker muscular dystrophy diabetes mellitus gastric carcinoma interstitial lung disease limb-girdle muscular dystrophy malignant glioma MALT lymphoma ovarian cancer pilocytic astrocytoma psoriasis malignant pancreatic neoplasm myopathy pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor adrenal cortex carcinoma Becker muscular dystrophy diabetes mellitus gastric carcinoma interstitial lung disease limb-girdle muscular dystrophy malignant glioma MALT lymphoma ovarian cancer pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor Crohn disease Duchenne muscular dystrophy glioblastoma juvenile dermatomyositis lung carcinoma malignant mesothelioma medulloblastoma pancreatic ductal adenocarcinoma pituitary cancer B-cell chronic lymphocytic leukemia cystic fibrosis Emery-Dreifuss muscular dystrophy interstitial cystitis large cell medulloblastoma malignant ependymoma
B	Pharos: P22692	malignant pancreatic neoplasm myopathy pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor adrenal cortex carcinoma Becker muscular dystrophy diabetes mellitus gastric carcinoma interstitial lung disease limb-girdle muscular dystrophy malignant glioma MALT lymphoma ovarian cancer pilocytic astrocytoma psoriasis malignant pancreatic neoplasm myopathy pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor adrenal cortex carcinoma Becker muscular dystrophy diabetes mellitus gastric carcinoma interstitial lung disease limb-girdle muscular dystrophy malignant glioma MALT lymphoma ovarian cancer pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor Crohn disease Duchenne muscular dystrophy glioblastoma juvenile dermatomyositis lung carcinoma malignant mesothelioma medulloblastoma pancreatic ductal adenocarcinoma pituitary cancer B-cell chronic lymphocytic leukemia cystic fibrosis Emery-Dreifuss muscular dystrophy interstitial cystitis large cell medulloblastoma malignant ependymoma
C [auth I]	Pharos: P05019	growth delay due to insulin-like growth factor type 1 deficiency acromegaly hypertensive disorder muscular atrophy breast carcinoma kidney disease adenoma Crohn disease Alzheimer disease precocious puberty pituitary gland adenoma microcystic adenoma pulmonary fibrosis Neoplasm Invasiveness skin neoplasm growth delay due to insulin-like growth factor type 1 deficiency acromegaly hypertensive disorder muscular atrophy breast carcinoma kidney disease adenoma Crohn disease Alzheimer disease precocious puberty pituitary gland adenoma microcystic adenoma pulmonary fibrosis Neoplasm Invasiveness skin neoplasm endometriosis cholestasis colitis coronary artery disease papillary adenoma demyelinating disease pituitary adenocarcinoma chronic kidney disease follicular thyroid adenoma urinary bladder cancer peripheral nervous system disease middle cerebral artery infarction prostate cancer breast cancer myopathy skin cancer corneal disease peripheral neuropathy medulloblastoma depressive disorder amyotrophic lateral sclerosis autism prostate disease hypopituitarism bipolar disorder ileocolitis Silver-Russell syndrome interstitial cystitis cancer neurodegenerative disease cerebrovascular disorder oligodendroglioma osteoporosis type 2 diabetes mellitus lung cancer pancreatic intraductal papillary-mucinous carcinoma malignant ependymoma pituitary tumor hyperglycemia astrocytic tumor hypoglycemia hypothyroidism myocardial ischemia inborn carbohydrate metabolic disorder breast disease Duchenne muscular dystrophy Sjogren syndrome invasive ductal breast carcinoma Emery-Dreifuss muscular dystrophy acute kidney failure osteogenesis imperfecta eye disease limb-girdle muscular dystrophy congenital diaphragmatic hernia ovarian cancer lung carcinoma pancreatic intraductal papillary-mucinous neoplasm alcohol abuse malignant glioma hepatocellular carcinoma pituitary cancer hyperinsulinism atopic eczema hypogonadism autoimmune disease psoriasis idiopathic interstitial pneumonia drug-induced liver injury intellectual disability ductal breast carcinoma in situ juvenile dermatomyositis obesity disorder Laron syndrome type 1 diabetes mellitus pancreatic ductal adenocarcinoma glioblastoma adrenal cortex carcinoma urinary bladder neoplasm lung disease Crohn's colitis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia malignant mesothelioma delirium