2DKC

Crystal structure of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, in the substrate complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PGM_PMM_IV	e2dkcA1	A: a+b two layers	X: TBP-like	H: Phosphoglucomutase, C-terminal domain (From Topology)	T: Phosphoglucomutase, C-terminal domain	F: PGM_PMM_IV	ECOD (1.6)
A	PGM_PMM_II	e2dkcA3	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_II	ECOD (1.6)
B	PGM_PMM_IV	e2dkcB18	A: a+b two layers	X: TBP-like	H: Phosphoglucomutase, C-terminal domain (From Topology)	T: Phosphoglucomutase, C-terminal domain	F: PGM_PMM_IV	ECOD (1.6)
B	PGM_PMM_II	e2dkcB20	A: a/b three-layered sandwiches	X: Phosphoglucomutase, first 3 domains (From Topology)	H: Phosphoglucomutase, first 3 domains (From Topology)	T: Phosphoglucomutase, first 3 domains	F: PGM_PMM_II	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.120.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 3	CATH (4.3.0)
A	3.30.310.50	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein	Alpha-D-phosphohexomutase, C-terminal domain	CATH (4.3.0)
B	3.40.120.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 3	CATH (4.3.0)
B	3.30.310.50	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein	Alpha-D-phosphohexomutase, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02878	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I (PGM_PMM_I)	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I	-	Domain
A, B	PF00408	Phosphoglucomutase/phosphomannomutase, C-terminal domain (PGM_PMM_IV)	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	Repeat
A, B	PF21405	Phosphoacetylglucosamine mutase AMG1, domain II (AMG1_II)	Phosphoacetylglucosamine mutase AMG1, domain II	Phosphoacetylglucosamine mutase (AMG1) catalyses the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc. It consists of four domains, the first three have the same fold of four beta-strands between two alp ...	Phosphoacetylglucosamine mutase (AMG1) catalyses the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc. It consists of four domains, the first three have the same fold of four beta-strands between two alpha-helices. This entry represents domain II of eukaryotic AMG1, which contains the metal-binding loop [1,2].	Domain
A, B	PF21404	Phosphoacetylglucosamine mutase AMG1, domain III (AMG1_III)	Phosphoacetylglucosamine mutase AMG1, domain III	Phosphoacetylglucosamine mutase (AMG1) catalyses the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc. It consists of four domains, the first three have the same fold of four beta-strands between two alp ...	Phosphoacetylglucosamine mutase (AMG1) catalyses the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc. It consists of four domains, the first three have the same fold of four beta-strands between two alpha-helices. This entry represents domain III of eukaryotic AMG1, which contains the sugar-binding loop [1,2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Phosphoacetylglucosamine mutase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoacetylglucosamine mutase activity isomerase activity intramolecular phosphotransferase activity catalytic activity intramolecular transferase activity	carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process amino sugar biosynthetic process cellular biosynthetic process cell wall organization or biogenesis organonitrogen compound biosynthetic process carbohydrate derivative metabolic process chitin metabolic process cellular component biogenesis cell wall chitin metabolic process amino sugar metabolic process organic substance biosynthetic process carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process amino sugar biosynthetic process cellular biosynthetic process cell wall organization or biogenesis organonitrogen compound biosynthetic process carbohydrate derivative metabolic process chitin metabolic process cellular component biogenesis cell wall chitin metabolic process amino sugar metabolic process organic substance biosynthetic process cellular component organization or biogenesis glucosamine-containing compound metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process fungal-type cell wall chitin biosynthetic process chitin biosynthetic process cellular metabolic process macromolecule biosynthetic process cell wall chitin biosynthetic process glucosamine-containing compound biosynthetic process fungal-type cell wall organization or biogenesis cell wall biogenesis biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process cellular process macromolecule metabolic process fungal-type cell wall biogenesis cell wall macromolecule metabolic process cellular component organization cell wall organization external encapsulating structure organization nucleotide-sugar metabolic process nucleobase-containing compound biosynthetic process UDP-N-acetylglucosamine biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleobase-containing small molecule metabolic process organic cyclic compound biosynthetic process small molecule metabolic process nucleotide-sugar biosynthetic process UDP-N-acetylglucosamine metabolic process phosphorus metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005843	Alpha-D-phosphohexomutase, C-terminal	Domain
A, B	IPR049023	Phosphoacetylglucosamine mutase AMG1, domain II	Domain
A, B	IPR016055	Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III	Homologous Superfamily
A, B	IPR016066	Alpha-D-phosphohexomutase, conserved site	Conserved Site
A, B	IPR005844	Alpha-D-phosphohexomutase, alpha/beta/alpha domain I	Domain
A, B	IPR016657	Phosphoacetylglucosamine mutase	Family
A, B	IPR036900	Alpha-D-phosphohexomutase, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR049022	Phosphoacetylglucosamine mutase AMG1, domain III	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.