2DG1

Crystal structure of Drp35, a 35kDa drug responsive protein from Staphylococcus aureus, complexed with Ca2+

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2dg1a2	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
A	d2dg1a3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
B	d2dg1b2	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
B	d2dg1b3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
C	d2dg1c_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
D	d2dg1d2	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
D	d2dg1d3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
E	d2dg1e2	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
E	d2dg1e3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
F	d2dg1f2	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
F	d2dg1f3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SGL-like	8027368	4003251	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08450	e2dg1A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
B	PF08450	e2dg1B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
C	PF08450	e2dg1C1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
D	PF08450	e2dg1D1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
E	PF08450	e2dg1E1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
F	PF08450	e2dg1F1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
B	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
C	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
D	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
E	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
F	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF08450	SMP-30/Gluconolactonase/LRE-like region (SGL)	SMP-30/Gluconolactonase/LRE-like region	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	DrP35	hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR013658	SMP-30/Gluconolactonase/LRE-like region	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.