2DG0

Crystal structure of Drp35, a 35kDa drug responsive protein from Staphylococcus aureus

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2dg0a1	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	Lactonase Drp35	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
A	d2dg0a2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
B	d2dg0b_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
C	d2dg0c_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
D	d2dg0d_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
E	d2dg0e2	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
E	d2dg0e3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
F	d2dg0f_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
G	d2dg0g_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
H	d2dg0h_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
I	d2dg0i_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
J	d2dg0j2	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
J	d2dg0j3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
K	d2dg0k_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)
L	d2dg0l_	All beta proteins	6-bladed beta-propeller	Calcium-dependent phosphotriesterase	SGL-like	automated matches	(Staphylococcus aureus ) [TaxId: 1280 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8039747	3000504	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08450	e2dg0A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
B	PF08450	e2dg0B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
C	PF08450	e2dg0C1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
D	PF08450	e2dg0D1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
E	PF08450	e2dg0E1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
F	PF08450	e2dg0F1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
G	PF08450	e2dg0G1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
H	PF08450	e2dg0H1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
I	PF08450	e2dg0I1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
J	PF08450	e2dg0J1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
K	PF08450	e2dg0K1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)
L	PF08450	e2dg0L1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF08450	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
B	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
C	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
D	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
E	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
F	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
G	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
H	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
I	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
J	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
K	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
L	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF08450	SMP-30/Gluconolactonase/LRE-like region (SGL)	SMP-30/Gluconolactonase/LRE-like region	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	DrP35	hydrolase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013658	SMP-30/Gluconolactonase/LRE-like region	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.