Annotations: 2DB7

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2db7a1	All alpha proteins	Orange domain-like	Orange domain-like	Hairy Orange domain	Hairy/enhancer-of-split related with YRPW motif protein 1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2db7a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2db7b2	All alpha proteins	Orange domain-like	Orange domain-like	Hairy Orange domain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2db7b3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Orange domain-like	8021368	4001342	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Orange domain-like	8033748	3001340	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Orange domain-like	8033748	3001340	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e2db7A1	A: alpha duplicates or obligate multimers	X: Hairy Orange domain (From Topology)	H: Hairy Orange domain (From Topology)	T: Hairy Orange domain	F: UNK_F_TYPE	ECOD (1.6)
B	UNK_F_TYPE	e2db7B1	A: alpha duplicates or obligate multimers	X: Hairy Orange domain (From Topology)	H: Hairy Orange domain (From Topology)	T: Hairy Orange domain	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.250.980	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	6.10.250.980	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07527	Hairy Orange (Hairy_orange)	Hairy Orange	The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split [1,2]. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute[2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Hairy/enhancer-of-split related with YRPW motif 1	DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein dimerization activity	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process multicellular organismal process cellular developmental process regulation of developmental process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cell differentiation system development developmental process negative regulation of developmental process nervous system development generation of neurons negative regulation of neuron differentiation regulation of neuron differentiation anatomical structure morphogenesis umbilical cord development umbilical cord morphogenesis regulation of multicellular organismal development cell development regulation of neurogenesis regulation of cell development regulation of nervous system development regulation of multicellular organismal process circulatory system development heart development cardiac chamber morphogenesis animal organ development heart morphogenesis ventricular septum development cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development labyrinthine layer blood vessel development placenta blood vessel development placenta development chordate embryonic development labyrinthine layer development embryo development in utero embryonic development vasculature development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development blood vessel development blood vessel morphogenesis tube development angiogenesis tube morphogenesis anatomical structure formation involved in morphogenesis cardiac ventricle morphogenesis heart trabecula formation heart trabecula morphogenesis trabecula formation trabecula morphogenesis smooth muscle cell differentiation regulation of smooth muscle cell differentiation negative regulation of muscle cell differentiation muscle cell differentiation muscle structure development negative regulation of smooth muscle cell differentiation regulation of muscle cell differentiation cellular response to stimulus response to stimulus negative regulation of signaling signaling regulation of signal transduction negative regulation of cell communication cell communication signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication regulation of vasculogenesis vasculogenesis heart valve development aortic valve development heart valve morphogenesis semi-lunar valve development aortic valve morphogenesis mesenchyme morphogenesis endocardial cushion morphogenesis mesenchyme development tissue development tissue morphogenesis endocardial cushion development pulmonary valve morphogenesis pulmonary valve development cardiac conduction system development cardiac muscle tissue development striated muscle tissue development muscle tissue development epithelial to mesenchymal transition cardiac epithelial to mesenchymal transition mesenchymal cell differentiation atrioventricular valve development atrioventricular valve formation heart valve formation atrioventricular valve morphogenesis negative regulation of biomineral tissue development regulation of biomineral tissue development biomineral tissue development transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II epithelium development endothelial cell differentiation endothelium development epithelial cell differentiation blood vessel endothelial cell differentiation arterial endothelial cell differentiation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process anterior/posterior pattern specification pattern specification process regionalization aorta morphogenesis artery development aorta development dorsal aorta morphogenesis artery morphogenesis dorsal aorta development	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003650	Orange domain	Domain
A, B	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
A, B	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y5J3	glioblastoma oligodendroglioma astrocytic tumor pilocytic astrocytoma oligoastrocytoma breast cancer cerebral primitive neuroectodermal tumor gemistocytic astrocytoma juvenile pilocytic astrocytoma adult oligodendroglioma medulloepithelioma breast carcinoma pancreatic ductal adenocarcinoma childhood cerebral astrocytoma protoplasmic astrocytoma glioblastoma oligodendroglioma astrocytic tumor pilocytic astrocytoma oligoastrocytoma breast cancer cerebral primitive neuroectodermal tumor gemistocytic astrocytoma juvenile pilocytic astrocytoma adult oligodendroglioma medulloepithelioma breast carcinoma pancreatic ductal adenocarcinoma childhood cerebral astrocytoma protoplasmic astrocytoma ependymoblastoma subependymal giant cell astrocytoma giant cell glioblastoma anaplastic astrocytoma childhood oligodendroglioma fibrillary astrocytoma tuberculosis Intracranial Astrocytoma lung benign neoplasm malignant glioma adrenal cortex carcinoma anaplastic oligodendroglioma medulloblastoma atypical teratoid rhabdoid tumor ovarian cancer primitive neuroectodermal tumor diffuse astrocytoma ureteral obstruction malignant mesothelioma nephrosclerosis autism spectrum disorder interstitial cystitis lung adenocarcinoma malignant ependymoma astrocytoma (excluding glioblastoma) cerebral astrocytoma psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.