2DA7

Solution structure of the homeobox domain of Zinc finger homeobox protein 1b (Smad interacting protein 1)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00046	e2da7A1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00046	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Zinc finger homeobox protein 1b	enzyme regulator activity phosphatase regulator activity molecular function regulator activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding cation binding ion binding metal ion binding small molecule binding	cell population proliferation endothelial cell proliferation cellular process epithelial cell proliferation epithelium migration multicellular organismal process tissue migration ameboidal-type cell migration epithelial cell migration cell migration cell motility melanocyte migration cellular response to stimulus positive regulation of cell communication cell population proliferation endothelial cell proliferation cellular process epithelial cell proliferation epithelium migration multicellular organismal process tissue migration ameboidal-type cell migration epithelial cell migration cell migration cell motility melanocyte migration cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction cellular response to growth factor stimulus response to stimulus signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction cell communication regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus biological regulation positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling endothelial cell migration regulation of myofibroblast cell apoptotic process regulation of apoptotic process myofibroblast cell apoptotic process regulation of programmed cell death cell death apoptotic process programmed cell death pyroptosis actomyosin structure organization actin cytoskeleton organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly actin filament bundle organization contractile actin filament bundle assembly actin filament-based process actin filament bundle assembly stress fiber assembly cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization pigment metabolic process regulation of melanin biosynthetic process organic hydroxy compound metabolic process pigment biosynthetic process melanin metabolic process secondary metabolic process positive regulation of secondary metabolite biosynthetic process positive regulation of metabolic process organic substance metabolic process secondary metabolite biosynthetic process positive regulation of biosynthetic process organic substance biosynthetic process regulation of biosynthetic process positive regulation of melanin biosynthetic process regulation of secondary metabolite biosynthetic process organic cyclic compound metabolic process regulation of secondary metabolic process biosynthetic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process phenol-containing compound biosynthetic process metabolic process melanin biosynthetic process regulation of metabolic process fibroblast activation cell activation regulation of actin filament-based process positive regulation of myofibroblast contraction actin filament-based movement regulation of actin filament-based movement regulation of myofibroblast contraction myofibroblast contraction positive regulation of actin filament-based movement actin-mediated cell contraction regulation of cellular component organization cellular pigmentation pigment granule organization regulation of organelle organization vesicle organization melanosome organization pigmentation regulation of melanosome organization developmental process anatomical structure development developmental pigmentation response to decreased oxygen levels response to nutrient levels response to oxygen levels response to abiotic stimulus response to oxygen-glucose deprivation cellular developmental process astrocyte differentiation cell development astrocyte activation glial cell development multicellular organism development neurogenesis astrocyte development gliogenesis cell differentiation response to stress system development defense response nervous system development central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response positive regulation of melanocyte differentiation pigment cell differentiation regulation of developmental process regulation of pigment cell differentiation regulation of cell differentiation regulation of pigmentation positive regulation of developmental process positive regulation of developmental pigmentation positive regulation of cell differentiation regulation of melanocyte differentiation positive regulation of pigment cell differentiation regulation of developmental pigmentation melanocyte differentiation myofibroblast differentiation cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway regulation of blood-brain barrier permeability system process maintenance of blood-brain barrier homeostatic process tissue homeostasis regulation of vascular permeability circulatory system process multicellular organismal-level homeostasis vascular process in circulatory system anatomical structure homeostasis regulation of biological quality blood circulation negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process negative regulation of locomotion regulation of cell motility regulation of fibroblast migration fibroblast migration negative regulation of fibroblast migration regulation of locomotion regulation of cell migration negative regulation of cell motility negative regulation of cell migration locomotion positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol nucleoplasm protein-containing complex protein-DNA complex chromatin chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001356	Homeobox domain	Domain
A	IPR013087	Zinc finger C2H2-type	Domain
A	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
A	IPR008598	Drought induced 19 protein type, zinc-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O60315	Mowat-Wilson syndrome breast carcinoma intellectual disability Liver Cirrhosis, Experimental renal cell carcinoma epilepsy Hirschsprung disease Down syndrome non-small cell lung carcinoma Emery-Dreifuss muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma Pick disease head and neck cancer primitive neuroectodermal tumor adenoma Mowat-Wilson syndrome breast carcinoma intellectual disability Liver Cirrhosis, Experimental renal cell carcinoma epilepsy Hirschsprung disease Down syndrome non-small cell lung carcinoma Emery-Dreifuss muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma Pick disease head and neck cancer primitive neuroectodermal tumor adenoma renal carcinoma Sjogren syndrome attention deficit hyperactivity disorder, inattentive type invasive ductal breast carcinoma breast cancer ulcerative colitis breast fibroadenoma lung carcinoma coloboma congenital heart disease microcephaly Duchenne muscular dystrophy osteosarcoma endogenous depression pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma heart disease progressive supranuclear palsy adrenal cortex carcinoma interstitial cystitis atypical teratoid rhabdoid tumor juvenile dermatomyositis thyroid gland papillary carcinoma lung adenocarcinoma cancer malignant glioma colorectal cancer craniosynostosis ductal breast carcinoma in situ ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia familial nonmedullary thyroid carcinoma psoriasis amyotrophic lateral sclerosis intestinal disease sarcoidosis subependymal giant cell astrocytoma bowel dysfunction large cell medulloblastoma tuberculosis breast disease lung cancer medulloblastoma degenerative myopia myopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.