Annotations: 2D9I

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2d9ia1	Alpha and beta proteins (a+b)	IF3-like	SMR domain-like	Smr domain	Nedd4-binding protein 2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2d9ia3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2d9ia2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Smr domain-like	8021363	4002072	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SMR domain-like	8033743	3000795	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01713	e2d9iA1	A: a+b two layers	X: IF3-like	H: Smr domain (From Topology)	T: Smr domain	F: PF01713	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1370.110	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01713	Smr domain (Smr)	Smr domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NEDD4-binding protein 2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA endonuclease activity endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on a nucleic acid hydrolase activity catalytic activity DNA nuclease activity protein binding ubiquitin binding ubiquitin-like protein binding nucleobase-containing compound kinase activity polynucleotide 5'-hydroxyl-kinase activity kinase activity ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity transferase activity ATP-dependent polynucleotide 5'-hydroxyl-kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	-	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041801	NEDD4-binding protein 2, CUE domain	Domain
A	IPR013899	Domain of unknown function DUF1771	Domain
A	IPR002625	Smr domain	Domain
A	IPR009060	UBA-like superfamily	Homologous Superfamily
A	IPR003892	Ubiquitin system component CUE	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR036063	Smr domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q86UW6	adrenoleukodystrophy Crohn disease malignant ependymoma medulloblastoma Pick disease rheumatoid arthritis astrocytic tumor glioblastoma malignant glioma oligodendroglioma pilocytic astrocytoma sarcoidosis atypical teratoid rhabdoid tumor large cell medulloblastoma Malignant neoplasm of breast adrenoleukodystrophy Crohn disease malignant ependymoma medulloblastoma Pick disease rheumatoid arthritis astrocytic tumor glioblastoma malignant glioma oligodendroglioma pilocytic astrocytoma sarcoidosis atypical teratoid rhabdoid tumor large cell medulloblastoma Malignant neoplasm of breast osteosarcoma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.