2D8U

Solution structure of the B-box domain of the human tripartite motif-containing 63 protein

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2d8ua1	Small proteins	B-box zinc-binding domain	B-box zinc-binding domain	B-box zinc-binding domain	Ubiquitin ligase trim63	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2d8ua3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d2d8ua2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Type 2 B-box zinc-binding domain	8021359	4003723	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	B-box zinc-binding domain	8033739	3001359	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	zf-B_box	e2d8uA1	A: few secondary structure elements	X: B-box zinc-binding domain-like	H: B-box zinc-binding domain (From Topology)	T: B-box zinc-binding domain	F: zf-B_box	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.160.60	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain	Classic Zinc Finger	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00643	B-box zinc finger (zf-B_box)	B-box zinc finger	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ubiquitin ligase TRIM63	cytoskeletal protein binding titin binding protein binding binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity cytoskeletal protein binding titin binding protein binding binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity	multicellular organismal process muscle atrophy system process striated muscle adaptation skeletal muscle atrophy muscle adaptation response to stimulus skeletal muscle adaptation muscle system process striated muscle atrophy muscle contraction response to organic substance response to chemical response to cytokine multicellular organismal process muscle atrophy system process striated muscle adaptation skeletal muscle atrophy muscle adaptation response to stimulus skeletal muscle adaptation muscle system process striated muscle atrophy muscle contraction response to organic substance response to chemical response to cytokine response to interleukin-1 muscle hypertrophy regulation of muscle adaptation regulation of biological process negative regulation of muscle hypertrophy regulation of system process negative regulation of biological process biological regulation striated muscle hypertrophy regulation of muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy regulation of response to stimulus cardiac muscle hypertrophy regulation of multicellular organismal process negative regulation of multicellular organismal process negative regulation of cardiac muscle hypertrophy organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular response to stimulus regulation of cellular process signaling cellular process signal transduction cell communication response to corticosteroid response to lipid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid response to organic cyclic compound response to electrical stimulus response to electrical stimulus involved in regulation of muscle adaptation response to stimulus involved in regulation of muscle adaptation response to abiotic stimulus	M band intracellular anatomical structure cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex M band intracellular anatomical structure cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle Z disc I band polymeric cytoskeletal fiber cytoskeleton microtubule microtubule cytoskeleton membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A	IPR000315	B-box-type zinc finger	Domain
A	IPR042667	E3 ubiquitin-protein ligase TRIM63, RING finger, HC subclass	Domain
A	IPR027370	Zinc finger, RING-type, eukaryotic	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR017903	COS domain	Domain
A	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q969Q1	muscular atrophy cardiomyopathy Cardiomegaly diabetes mellitus hypertrophic cardiomyopathy lung adenocarcinoma myopathy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.