Flagellar hook-associated protein 1, D2-like domain
This entry includes Flagellar hook-associated protein 1 (FlgK or HAP1), one of three HAPs that form the hook-filament junction and has structural similarity to flagellin. FlgK is required for normal flagellum assembly. Proteins in this entry have a m ...
This entry includes Flagellar hook-associated protein 1 (FlgK or HAP1), one of three HAPs that form the hook-filament junction and has structural similarity to flagellin. FlgK is required for normal flagellum assembly. Proteins in this entry have a multidomain fold comprising an elongated alpha-helical scaffold core, and depending on the bacterial species, a variable number of smaller domains [1]. This entry represents a beta-sandwich domain from FlgK proteins; Salmonella typhimurium FlgK (Swiss:P0A1J5) has one beta-sandwich domain, while FlgK from Burkholderia pseudomallei has two of them protruding from the alpha-helical core, referred to as D2 and D3 domains in [1], of which the first one, D2, is covered in this entry [1]. FlgK has cytotoxic effects suggesting an important role in pathogenesis and is highly immunogenic. Domains D2 and D3 from B. pseudomallei have been identified as epitopes with increased immunogenic potential for vaccine development.
Flagellar basal body rod FlgEFG protein C-terminal
This family consists of a number of C-terminal domains of unknown function. This domain seems to be specific to flagellar basal-body rod and flagellar hook proteins in which Pfam:PF00460 is often present at the extreme N terminus.
