2D1I

Structure of human Atg4b

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2d1ia1	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Autophagin-like	Cysteine protease ATG4B	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2d1ib_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Autophagin-like	Cysteine protease ATG4B	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Autophagin-like	8021337	4002557	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cysteine proteinases	8033717	3001808	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cysteine proteinases	8033717	3001808	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03416	e2d1iA1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF03416	ECOD (1.6)
B	PF03416	e2d1iB1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF03416	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF20166	ATG4, F-type LIR motif (ATG4_LIR)	ATG4, F-type LIR motif	-	Motif
A, B	PF03416	Peptidase family C54 (Peptidase_C54)	Peptidase family C54	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cysteine protease APG4B	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activity scaffold protein binding protein binding binding protein-phosphatidylethanolamide deconjugating activity	developmental process ear development sensory organ development animal organ development tissue development otolith mineralization otolith development otolith mineralization completed early in development inner ear development anatomical structure development biomineral tissue development cellular catabolic process catabolic process macroautophagy developmental process ear development sensory organ development animal organ development tissue development otolith mineralization otolith development otolith mineralization completed early in development inner ear development anatomical structure development biomineral tissue development cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism organic substance metabolic process organonitrogen compound metabolic process macromolecule modification protein delipidation primary metabolic process protein metabolic process macromolecule metabolic process protein modification process autophagosome assembly organelle assembly vacuole organization autophagosome organization cellular component biogenesis cellular component organization organelle organization cellular component assembly cellular component organization or biogenesis microautophagy protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular component disassembly mitophagy organelle disassembly autophagy of mitochondrion mitochondrion organization proteolysis protein localization to phagophore assembly site	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytoplasmic vesicle intracellular vesicle vesicle vacuolar membrane autophagosome membrane membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytoplasmic vesicle intracellular vesicle vesicle vacuolar membrane autophagosome membrane membrane vacuole autophagosome bounding membrane of organelle organelle membrane cytosol endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR046792	Peptidase C54, catalytic domain	Domain
A, B	IPR005078	Peptidase C54	Family
A, B	IPR046793	Cysteine protease ATG4, F-type LIR motif	Conserved Site
A, B	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y4P1	allergic rhinitis breast carcinoma ovarian cancer asthma inflammatory bowel disease psoriasis brain glioma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.